Relationship of serum levels and dietary intake of isoflavone, and the novel bacterium Slackia sp. strain NATTS with the risk of prostate cancer: a case–control study among Japanese men

Nagata, Yasunobu; Sugiyama, Yukiko; Fukuta, Fumimasa; Takayanagi, Akio; Masumori, Naoya; Tsukamoto, Taiji; Akasaka, Hiroshi; Ohnishi, Hirofumi; Saitoh, Shigeyuki; Miura, Tetsuji; Moriyama, Kaoru; Tsuji, Hirokazu; Akaza, Hideyuki; Mori, Mitsuru

doi:10.1007/s11255-016-1335-7

Cited by 19 publications

(14 citation statements)

References 36 publications

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“…Of the 2531 articles that were screened by abstract, 39 articles were found to contain potentially relevant information and were evaluated by full text review. Upon reviewing the full text articles for the aforementioned inclusion criteria, 30 articles were included in the final analysis [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 ]. Of these 30 articles, 24 [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 45 , 46 , 47 , 48 ,…”

Section: Resultsmentioning

confidence: 99%

“…Of the 30 articles included for analysis, fifteen [ 28 , 29 , 30 , 32 , 34 , 37 , 38 , 39 , 41 , 42 , 47 , 48 , 49 , 52 , 56 ] articles were case-control studies, eight [ 27 , 31 , 33 , 36 , 43 , 45 , 46 , 53 ] articles were cohort studies, and seven [ 35 , 40 , 44 , 50 , 51 , 54 , 55 ] articles were nested case-control studies (NCC). The total number of study participants included was 266,699, and the total number of PCa cases reported was 21,612.…”

Section: Resultsmentioning

confidence: 99%

“…The total number of study participants included was 266,699, and the total number of PCa cases reported was 21,612. Twelve [ 27 , 32 , 35 , 36 , 37 , 39 , 41 , 42 , 44 , 47 , 49 , 56 ] articles reported data from Asia, ten [ 31 , 33 , 34 , 38 , 43 , 45 , 46 , 48 , 52 , 53 ] articles reported data from North America, and eight [ 28 , 29 , 30 , 40 , 50 , 51 , 54 , 55 ] articles reported data from Europe. The study characteristics are summarized in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

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Soy Consumption and the Risk of Prostate Cancer: An Updated Systematic Review and Meta-Analysis

et al. 2018

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Prostate cancer (PCa) is the second most commonly diagnosed cancer in men, accounting for 15% of all cancers in men worldwide. Asian populations consume soy foods as part of a regular diet, which may contribute to the lower PCa incidence observed in these countries. This meta-analysis provides a comprehensive updated analysis that builds on previously published meta-analyses, demonstrating that soy foods and their isoflavones (genistein and daidzein) are associated with a lower risk of prostate carcinogenesis. Thirty articles were included for analysis of the potential impacts of soy food intake, isoflavone intake, and circulating isoflavone levels, on both primary and advanced PCa. Total soy food (p < 0.001), genistein (p = 0.008), daidzein (p = 0.018), and unfermented soy food (p < 0.001) intakes were significantly associated with a reduced risk of PCa. Fermented soy food intake, total isoflavone intake, and circulating isoflavones were not associated with PCa risk. Neither soy food intake nor circulating isoflavones were associated with advanced PCa risk, although very few studies currently exist to examine potential associations. Combined, this evidence from observational studies shows a statistically significant association between soy consumption and decreased PCa risk. Further studies are required to support soy consumption as a prophylactic dietary approach to reduce PCa carcinogenesis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Soy Consumption and the Risk of Prostate Cancer: An Updated Systematic Review and Meta-Analysis

et al. 2018

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“…Members of Eubacterium and Clostridium_IV have been revealed to be major butyrate-producing bacteria in the human colon 51 . Members of Slackia have been shown to exhibit a high adhesion capacity to human Caco-2 cells 52 and to also be involved in the pathogenesis of prostate cancer 53 . However, little information is presently available on the cell-wall components and metabolites of the gut bacteria that belong to these clades.…”

Section: Discussionmentioning

confidence: 99%

Diet-induced reconstruction of mucosal microbiota associated with alterations of epithelium lectin expression and regulation in the maintenance of rumen homeostasis

Shen

et al. 2017

Sci Rep

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It is unknown whether lectins of the rumen epithelium contribute to the recognition of mucosal microbes and activation of tolerogenic cytokines in ruminant animals. We applied an integrated method of RNA-seq and 16S rRNA gene sequencing to investigate alterations of epithelial lectin expression and regulation with a diet-induced reconstruction of the mucosal microbiota in the goat rumen. Our results showed that the diversity and richness of the rumen mucosal microbiota were promoted by the dietary concentrate. Meantime, in the rumen epithelium, five lectin genes, namely, sialic acid-binding Ig-like lectin 14 (LOC102180073), C-type lectin domain family 4, member E (CLEC4E), C-type lectin domain family 7, member A (CLEC7A), C-type lectin domain family 16, member A (CLEC16A), and lectin, mannose-binding 2 (LMAN2), were indicated to promote the expression of 8 tolerogenic cytokines, transforming growth factor beta 1 (TGFB1) and 4 enzyme genes involved in retinoic acid biosynthesis via 6 signaling pathways. Analysis of the combined data showed that 9 microbial genera (Clostridium_IV, Desulfobulbus, Eubacterium, Ochrobactrum, Propionibacterium, Pseudomonas, Slackia, Staphylococcus and Subdivision5_genera_IS) were highly related to the expression of functional lectins. These findings provide new insights into the interactions between the rumen epithelium and mucosal microbiota in the maintenance of rumen homeostasis.

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“…Accumulating epidemiological evidence has highlighted a geographical basis for PCa incidence, and isoflavone consumption may be related to this phenomenon. Indeed, PCa is more common in Western than Asian populations, and several trials have demonstrated that soy derivatives genistein and daidzein can prevent the development and progression of this tumor in Japanese and Chinese men [293][294][295][296]. On the contrary, the data collected in European patients are still contradictory.…”

Section: Clinical Impactmentioning

confidence: 99%

Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets

Fontana

Raimondi

Marzagalli

et al. 2020

Cells

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Prostate cancer (PCa) represents a major cause of cancer mortality among men in developed countries. Patients with recurrent disease initially respond to androgen-deprivation therapy, but the tumor eventually progresses into castration-resistant PCa; in this condition, tumor cells acquire the ability to escape cell death and develop resistance to current therapies. Thus, new therapeutic approaches for PCa management are urgently needed. In this setting, natural products have been extensively studied for their anti-PCa activities, such as tumor growth suppression, cell death induction, and inhibition of metastasis and angiogenesis. Additionally, numerous studies have shown that phytochemicals can specifically target the androgen receptor (AR) signaling, as well as the PCa stem cells (PCSCs). Interestingly, many clinical trials have been conducted to test the efficacy of nutraceuticals in human subjects, and they have partially confirmed the promising results obtained in vitro and in preclinical models. This article summarizes the anti-cancer mechanisms and therapeutic potentials of different natural compounds in the context of PCa prevention and treatment.

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Relationship of serum levels and dietary intake of isoflavone, and the novel bacterium Slackia sp. strain NATTS with the risk of prostate cancer: a case–control study among Japanese men

Abstract: Our study findings suggest that high serum levels of genistein, daidzein, and glycitein are significantly associated with a decreased risk of prostate cancer among Japanese men.

Cited by 19 publications

References 36 publications

Soy Consumption and the Risk of Prostate Cancer: An Updated Systematic Review and Meta-Analysis

Soy Consumption and the Risk of Prostate Cancer: An Updated Systematic Review and Meta-Analysis

Diet-induced reconstruction of mucosal microbiota associated with alterations of epithelium lectin expression and regulation in the maintenance of rumen homeostasis

Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets

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