Relationship of serum TWEAK level to cytokine level, disease activity, and response to anti‐TNF treatment in patients with rheumatoid arthritis

Abstract

Serum levels of TWEAK were significantly elevated in patients with RA, and reflected disease activity and short-term response to etanercept treatment.

Serum Levels of Anti-Citrullinated Protein Antibody (ACPA) and TWEAK in Patients with Rheumatoid Arthritis: Association with Disease Activity and Treatment Modalities

“…[16] However, little is known about the effect of anti-TnF-alpha on TWEAK expression. Park et al [8] reported that serum levels of TWEAK were significantly elevated in patients with RA, and indicated a short-lived response to anti-TnF-alpha. However, in anti-TnF-alpha non-responder patients, the serum TWEAK levels were reported to remain unchanged.…”

“…However, in anti-TnF-alpha non-responder patients, the serum TWEAK levels were reported to remain unchanged. [8] ın a recent study, TWEAK and its fibronectin (Fn) receptor were found to be expressed in the inflamed synovium of RA and psoriatic arthritis patients. of particular interest was the fact that TWEAK and Fn expression were unchanged after four weeks of anti-TnF-alpha treatment.…”

“…ın a recent study, it was reported that serum TWEAK levels in patients with RA were correlated with disease activity, and these significantly decreased with antiTnF-alpha treatment. [8] ın this study, we investigated the serum levels of TWEAK, anti-CCP, and anti-MCv in patients with RA and attempted to determine whether the aforementioned parameters are associated with disease activity, levels of cytokines (TnF and interleukin-1 (ıl-1), and anti-TnF-alpha treatment.…”

RG7212 Anti-TWEAK mAb Inhibits Tumor Growth through Inhibition of Tumor Cell Proliferation and Survival Signaling and by Enhancing the Host Antitumor Immune Response

“…In contrast to data showing TWEAK proinflammatory, proangiogenic, and proliferation-inducing effects in disease models in animals (5,(23)(24)(25) and association of pathway activation with human disease (21,22,(26)(27)(28), some published in vitro studies have shown that TWEAK induces apoptosis via upregulation of TNFa (29) or in combination with IFNg in a small number of tumor cell lines (8). In the absence of IFNg, apoptosis induction was modest (30) or required relatively high TWEAK concentrations (29).…”

Apoptosis Resistance in Rheumatoid Arthritis Synovial Tissue

“…Rather CD45 is a protein tyrosine kinase biomarker present on the precursor cell that may eventually differentiate into granulocytes, T-and B-cells, monocytes and thrombocytes. Another study showed that TWEAK levels were substantially elevated in the serum of RA patients and that serum TWEAK levels correlated with RA disease activity [32].…”