Relationship of symptoms to occupational styrene exposure and to the findings of electroencephalographic and psychological examinations

Härkönen, Hannu

doi:10.1007/bf00381410

Cited by 49 publications

(23 citation statements)

References 11 publications

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“…Many investigations, most from the reinforced plastics industries, have demonstrated that styrene exposure is related to the prevalence of subjective neuropsychiatsic complaints, including excessive fatigue, concentration and memory difficulties, and mood instability (7)(8)(9). In addition, abnormal electrocephalographic recordings (10)(11)(12), a decrease in nerve conduction velocity (SO), a reduction in psychomotor speed (13)(14)(15)(16), auditory problems (17), and a high prevalence of acquired color vision loss (18)(19)(20) have been observed among styrene-exposed workers.…”

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Visual dysfunction among styrene exposed workers

Campagna¹,

Mergler²,

Huel³

et al. 1995

Scand J Work Environ Health

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dysfunction among styreneexposed workers. Scand J Work Environ Health 1995;21:382-90. Objectives The present study was undertaken to examine the relation between visual functions and occupational exposure to styrene. Methods A total of 128 workers (85% of the total population), from three glass-reinforced plastics plants in Canada, agreed to participate in the study. Environmental and biological measures were made on the day(s) prior to the assessment of near visual acuity (National Optical Visual Chart), chromatic discrimination (Lanthony D-15 desaturated panel), and near contrast sensitivity (Vistech 6000). The analyses were performed on 81 workers with near visual acuity of at least 1 min of arc at 0.5 m. Results The subjects were relatively young [29 (SD 8) years], with little seniority [5 (SD 4) years]. Styrene exposure for 8 h ranged from 6 to 937 (first quartile 21 mg . m-' , third quartile 303 mg . m-'), depending on the job site. The end-shift concentrations of urinary mandelic acid ranged from nondetectable to 1.90 mmol . mmol creatinine-l. Significant positive relations were found between the internal and external styrene exposure measurements and color vision loss adjusted for age, alcohol consumption, and seniority in a multiple regression analysis. The multiple regression analysis also showed that the end-shift concentration of urinary mandelic acid was inversely related to contrast sensitivity at 6 and 12 cycles . degree-'. Logistic multiple regression models indicated that the end-shift concentration of urinary mandelic acid was related to the prevalences of blurred vision, tearing, and eye irritation. C O~C~U S~O~S These findings suggest that there is a positive relation between styrene exposure and early color and contrast vision dysfunction.

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Visual dysfunction among styrene exposed workers

Campagna¹,

Mergler²,

Huel³

et al. 1995

Scand J Work Environ Health

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“…The most common symptoms reported in studies of workers chronically exposed to different organic solvents are unusual tiredness, concentration difficulties, impaired memory, and dizziness (7,9,10,15,18,19). In addition Cianchetti et al (4) have described 122 cases of polyneuropathy; they listed the following symptoms: anorexia, nausea and vomiting, epigastric pain, headache, dizziness, and insomnia.…”

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“…The questions dealing with general symptoms were formulated so that they covered symptoms revealed in earlier studies on solvent exposure, ie, unusual tiredness, fatigue, sleeping difficulties, impaired memory, concentration difficulties, vegetative symptoms, disturbances in vigilance, dizziness, and symptoms of peripheral neuropathy (2,3,7,9,10,16,22,27). Acute symptoms were probed with questions about irritation of the mucous membranes and skin, and the "prenarcotic" effects of solvents (15,18,19,23).…”

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“…A three-step rating scale (never, sometimes, often) was used in the questionnaire, which was constructed in a language that was simple and unambiguous in order to facilitate answering. The same questions had been used in an investigation of styrene-exposed workers (9), except those on alcohol consumption which were standardized questions developed in the Finnish Social Research Institute of Alcohol Studies (21).…”

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Symptoms of car painters with long-term exposure to a mixture of organic solvents.

Husman¹

1980

Scand J Work Environ Health

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“…Quite another approach was used for the EEGs: here conventional clinical criteria were used (no-mean values are possible for EEG findings). It can be added that applying the same criteria yields about 10% "abnormal" results in an unselected general population (Harkonen, 1977). An index, based on intensity times duration was tried, but it did not change the results.…”

Section: Answermentioning

confidence: 99%