Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans

Valina-Toth, Anna Liza; Lai, Zongshan; Yoo, Wonsuk; Abou‐Samra, Abdul‐Badi; Gadegbeku, Crystal A.; Flack, John M.

doi:10.1111/j.1365-2265.2009.03676.x

Cited by 48 publications

(38 citation statements)

References 50 publications

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“…50,51 However, in contrast to previous studies in adults, 52,53 as well as in contrast to the findings in our studied women, our analyses did not show an inverse correlation between plasma 25OHD and PTH levels in infants. We do not believe that this necessary suggest an altered relationship between plasma 25OHD and PTH levels in newborns.…”

Section: Maternal and Infant Vitamin D Status S Vij Streym Et Alcontrasting

confidence: 56%

Maternal and infant vitamin D status during the first 9 months of infant life—a cohort study

et al. 2013

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BACKGROUND/OBJECTIVES: The objective of this study was to assess vitamin D status and possible consequences of low plasma 25-hydroxyvitamin D (25OHD) levels in a population of healthy mothers and their infants. SUBJECTS/METHODS: A total of 107 women aged 24-41 years gave birth to 108 infants. They were followed up three times during 9 months. RESULTS: Cord blood 25OHD level (43.3 ± 20.4 nmol/l) on average was 62 ± 16% of maternal levels (73.3 ± 30.7 nmol/l), measured 1-2 weeks postpartum. Cord blood 25OHD correlated positively with maternal 25OHD levels (r ¼ 0.83, Po0.001). At birth, 23% of mothers and 61% of infants had 25OHD o50 nmol/l. Vitamin D deficiency (25OHDo25 nmol/l) was present in 66% of the children born by mothers with 25OHD levels below 50 nmol/l (Po0.01), whereas only one child was born with deficiency among mothers with 25OHD 450 nmol/l. During follow-up, most of the children (485%) had 25OHD levels 450 nmol/l, which most likely was attributable to the use of supplements, as more than 95% of the children were given daily vitamin D supplements of 10 mg of vitamin D. Cord blood parathyroid hormone levels were very low (median 0.21; interquartile range 0.11-0.33 pmol/l), with increasing levels (Po0.01) reaching 3.08 (2.67-3.92 pmol/l) at the last visit. Vitamin D levels were not associated with anthropometric indices of the newborn infant or their growth during follow-up. CONCLUSIONS: Vitamin D deficiency is widespread in newborn. Maternal 25OHD levels above 50 nmol/l are needed to prevent vitamin D deficiency among newborn.

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Section: Maternal and Infant Vitamin D Status S Vij Streym Et Alcontrasting

confidence: 56%

Maternal and infant vitamin D status during the first 9 months of infant life—a cohort study

et al. 2013

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“…[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] Some of the most recent information about low vitamin D status and obesity comes from studies in bariatric surgery patients, reporting low preoperative circulating levels of 25-hydroxyvitamin D. [21][22][23][24][25][26][27][33][34][35][36][37][38] In fact, a recent systematic review of 14 studies with about 1500 patients undergoing bariatric surgical procedures confirmed that obese individuals have serum 25-hydroxyvitamin D levels below 80 nmol l À1 preoperatively. 39 Other investigators have reported that body mass index (BMI) 25,26,[40][41][42][43][44][45][46] and body fat 20,45,[47][48][49]…”

Section: Methodsmentioning

confidence: 99%

The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications

et al. 2011

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Obesity and vitamin D deficiency have both been recognized as major public health issues worldwide, and there is growing evidence that they are related, although the cause-effect relationship remains unclear. Could obesity be contributing to low circulating 25-hydroxyvitamin D concentrations? Alternatively, could low vitamin D status predispose to obesity? In this review, the relationship between low circulating 25-hydroxyvitamin D and obesity, and possible underlying reasons from both perspectives, is presented. One potential mechanism by which obesity could contribute to low serum 25-hydroxyvitamin D is adipose sequestration of vitamin D. On the other hand, adipose tissue has both the vitamin D receptor and the ability to synthesize 1,25-dihydroxyvitamin D, and there is evidence that vitamin D may regulate adipose tissue mass, differentiation and metabolism in ways that might contribute to obesity. Of particular interest, vitamin D deficiency is common both before and after bariatric surgery, and is often difficult to treat, particularly with the more malabsorptive procedures. Additional research is needed to elucidate the complex and multifaceted factors underlying the association between low circulating 25-hydroxyvitamin D and obesity, and to identify optimal treatment approaches in obese individuals and in bariatric surgical patients both before and after surgery.

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“…Because aldosterone causes the body to retain water and sodium by increasing the reabsorption from kidney tubules, increased 25(OH)D is believed to lower BP through reducing aldosterone concentrations (9,10). A deficiency of 25(OH)D can also cause secondary increased secretion of parathyroid hormone (PTH) and increase the risk of inflammation and an elevated concentration of inflammatory markers, such as C-reactive protein (CRP) (11). Low-grade inflammation, as indicated by increased plasma concentrations of CRP, may increase the likelihood of developing insulin resistance and subsequent hyperinsulinemia either by influencing insulin signaling in peripheral tissues or by inducing b cell dysfunction (12).…”

Section: Introductionmentioning

confidence: 99%

Associations between Vitamin D and Cardiovascular Disease Risk Factors in African Americans Are Partly Explained by Circulating Adipokines and C-Reactive Protein: The Jackson Heart Study

Khan

Gebreab

Riestra

et al. 2016

The Journal of Nutrition

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Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans

Abstract: Background-Obesity disproportionately affects African Americans (AA) (especially women), and is linked to depressed 25-hydroxyvitamin D (25-OH D) and elevated parathyroid hormone (PTH). The relationship of 25-OH D and PTH to body composition and size in AA is not well known.

Cited by 48 publications

References 50 publications

Maternal and infant vitamin D status during the first 9 months of infant life—a cohort study

Maternal and infant vitamin D status during the first 9 months of infant life—a cohort study

The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications

Associations between Vitamin D and Cardiovascular Disease Risk Factors in African Americans Are Partly Explained by Circulating Adipokines and C-Reactive Protein: The Jackson Heart Study

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