Associations between Vitamin D and Cardiovascular Disease Risk Factors in African Americans Are Partly Explained by Circulating Adipokines and C-Reactive Protein: The Jackson Heart Study

Khan, Rehanullah; Gebreab, Samson Y.; Riestra, Pía; Sims, Mario; Gaye, Amadou Thierno; Xu, Rongbin; Davis, Sharon

doi:10.3945/jn.116.239509

Cited by 19 publications

(15 citation statements)

References 36 publications

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“…The anti‐inflammatory actions of vitamin D discussed earlier, including the regulation of NF‐κB and down‐regulation of pro‐inflammatory cytokines such as IL‐6, may also protect against atherosclerosis. This is supported by the large epidemiological Jackson's Heart Study of CVD risk factors in African–Americans, which showed that the relationship between vitamin D and CVD was partially mediated through C‐reactive protein and adipokines.…”

Section: Vitamin D and Cardiovascular Diseasesmentioning

confidence: 80%

Vitamin D and cardiometabolic disorders: a review of current evidence, genetic determinants and pathomechanisms

2018

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Vitamin D deficiency has been implicated in the pathophysiology of cardiometabolic disorders including obesity, type 2 diabetes mellitus, cardiovascular diseases and polycystic ovary syndrome. Despite a large number of experimental and observational studies supporting a role for vitamin D in these pathologies, randomized controlled trials have reported little to no effect of vitamin D supplementation in the prevention or treatment of these disorders, although some results remain ambiguous. Polymorphisms in genes related to vitamin D metabolism, particularly in the vitamin D receptor and binding protein and the metabolizing enzyme 1-α-hydroxylase, have emerged as potential contributors to these divergent results. It is now becoming increasingly recognized that the effects and potential benefits of vitamin D supplementation may vary by several factors including vitamin D deficiency status, ethnicity and/or the presence of genetic variants, which affect individual responses to supplementation. However, these factors have seldom been explored in the available literature. Future trials should consider inter-individual differences and, in particular, should aim to clarify whether certain subgroups of individuals may benefit from vitamin D supplementation in the context of cardiometabolic health.

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Section: Vitamin D and Cardiovascular Diseasesmentioning

confidence: 80%

Vitamin D and cardiometabolic disorders: a review of current evidence, genetic determinants and pathomechanisms

2018

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“…However, other researchers found no significant difference in the circulating adiponectin concentrations between PCOS and non-PCOS groups [34] , and such discrepancy could be related to the ethnic and demographic variations among the studied populations [34] . Toward this latter suggestion, positive correlations of systemic vitamin D status with circulating adiponectin, and hypoadiponectinemia is a link between hypovitaminosis D and IR, have been detected among diabetic Saudi patients [39] and also among African American patients with cardiovascular disease [40] .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of hypovitaminosis D, and its association with hypoadiponectinemia and hyperfollistatinemia, in Saudi women with naïve polycystic ovary syndrome

Kensara

2018

Journal of Clinical & Translational Endocrinology

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HighlightsHypovitaminosis D is prevalent in Saudi women with polycystic ovarian syndrome (PCOS).Serum 25(OH)D of PCOS patients were correlated positively with adiponectin and FSH.Serum 25(OH)D of PCOS patients was correlated negatively with markers of insulin resistance.Serum 25(OH)D of PCOS patients was correlated negatively with follistatin, LH, and androgens.Hypovitaminosis D, with low adiponectin and excess follistatin, is being a risk in PCOS.

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“…(3) Hypovitaminosis D may have an adverse effect on endothelial function and eventually lead to an increased stiffness of the aorta [ 48 ]. (4) Vitamin D can improve insulin secretion by activating vitamin D receptors in pancreatic islet β -cells [ 49 ]. In the present study, 25(OH)D is associated with HOMA-IR, HOMA- β , and RBP4, and after vitamin D therapy, the three indexes were all improved.…”

Section: Discussionmentioning

confidence: 99%

Involvement of RBP4 in Diabetic Atherosclerosis and the Role of Vitamin D Intervention

Zhou

Chen

et al. 2018

Journal of Diabetes Research

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The purposes of this study were to evaluate the expression of retinol-binding protein 4 (RBP4) in diabetic rats with atherosclerosis and to investigate the role of vitamin D intervention. Male Wistar rats were randomly divided into 4 groups, including the control group (NC), the diabetic rats (DM1), the untreated diabetic atherosclerosis rats (DM2), and the vitamin D-treated diabetic atherosclerosis rats (DM3). The levels of serum and adipose RBP4, fasting insulin (FINS), fasting plasma glucose (FPG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), 25-hydroxyvitamin D [25(OH)D], C-reactive protein (CRP), and systolic blood pressure (SBP) were measured. Homeostasis model assessment of insulin resistance (HOMA-IR), homeostasis model assessment β-cell function index (HOMA-β), and atherogenic indexes (AI) were calculated. Compared with group NC, the levels of RBP4, TG, LDL-c, FPG, FINS, CRP, AI1, AI2, SBP, and HOMA-IR increased, while the levels of HDL-c, 25(OH)D, and HOMA-β decreased in groups DM1 and DM2. After 8 weeks of vitamin D supplementation in group DM3, the levels of 25(OH)D and HOMA-β increased and the levels of LDL-c, TC, HOMA-IR, FINS, CRP, RBP4, AI1, AI2, and SBP decreased significantly when compared with group DM2 (P < 0.05); Pearson analysis showed that serum RBP4 was positively correlated with TG, FINS, HOMA-IR, SBP, CRP, and AI and negatively correlated with 25(OH)D. In addition, multivariable logistic regression analysis showed that serum RBP4, SBP, and HDL-c were predictors for the presence of diabetic atherosclerosis. These findings suggested that RBP4 could involve in the improvement of diabetic atherosclerosis; vitamin D had the ability to decrease the level of RBP4 and eventually played an important role in preventing atherosclerosis in diabetes.

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Associations between Vitamin D and Cardiovascular Disease Risk Factors in African Americans Are Partly Explained by Circulating Adipokines and C-Reactive Protein: The Jackson Heart Study

Abstract: Background: Although it is recognized that vitamin D deficiency is associated with cardiovascular disease (CVD) risk

Cited by 19 publications

References 36 publications

Vitamin D and cardiometabolic disorders: a review of current evidence, genetic determinants and pathomechanisms

Vitamin D and cardiometabolic disorders: a review of current evidence, genetic determinants and pathomechanisms

Prevalence of hypovitaminosis D, and its association with hypoadiponectinemia and hyperfollistatinemia, in Saudi women with naïve polycystic ovary syndrome

Involvement of RBP4 in Diabetic Atherosclerosis and the Role of Vitamin D Intervention

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