Vitamin <scp>D</scp> and cardiometabolic disorders: a review of current evidence, genetic determinants and pathomechanisms

Marquina, Clara; Mousa, Aya; Scragg, Robert

doi:10.1111/obr.12793

Cited by 44 publications

(48 citation statements)

References 150 publications

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“…We found that severity of obesity was inversely related to vitamin D levels after controlling for age and sex. Similar to our results, current evidence suggests that greater obesity leads to lower 25-OH vit D levels, while the opposite relationship is generally not shown (27). There are many possible hypotheses to account for the lower 25-OH vit D concentrations in obese individuals (10,(27)(28)(29).…”

Section: Discussionsupporting

confidence: 87%

Şişmanlığın derecesi ile kardiyometabolik riskler ve vitamin D düzeyi arasındaki ilişki

et al. 2019

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The aim of this study was to evaluate the cardiometabolic risk factors including vitamin D levels according to the degree of obesity in adolescents. Material and Methods: This is a retrospective cross-sectional study. A total of 363 overweight/obese adolescents aged between 11 and 18 years who were evaluated in our clinic from January 2012 to December 2015 were included in the study. The degree of obesity was calculated as the body mass index standard deviation. Hypertension, dyslipidemia, hyperinsulinemia, hyperglycemia, insulin resistance, and vitamin D deficiency were defined as cardiometabolic risk factors. Mann-Whitney U, Chi-square, Spearman and Pearson's correlation tests, and linear regressions analyses were used for statistical analyses. Results: Of the 319 (n=319/363) adolescents, all of whose cardiometabolic risk factors were known, 267 (85.7%) had at least one cardiometabolic risk factor. The body mass index standard deviation had a positive correlation with the number of cardiometabolic risk factors (p<0.001). In the linear regression models in which sex and age were considered as covariates, an increase of one unit in the body mass index standard deviation led to an increase of 6.085 mm Hg in systolic blood pressure, 4.4 mm Hg in diastolic blood pressure, 1.59 points in HOMA-IR, 13% in insulin level, and a decrease of 2.16 ng/mL in vitamin D levels. Conclusion: In adolescents, the number of cardiometabolic risk factors increases as the degree of obesity increases. The determination of the severity of obesity can help to identify individuals at greater risk for higher blood pressure, impaired glucose metabolism, and lower serum vitamin D levels. On the other hand, the degree of obesity may not reflect the presence of abnormal lipid and glucose levels.

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Section: Discussionsupporting

confidence: 87%

Şişmanlığın derecesi ile kardiyometabolik riskler ve vitamin D düzeyi arasındaki ilişki

et al. 2019

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“…The 25(OH)D3 is widely used in assessment of vitamin D status. 25(OH)D3 is converted in the liver to 1,25(OH)2D, which is the main ligand for VDR [29]. When 1,25(OH)2D binds to this complex, it leads to the transcription of several vitamin D-regulated genes [23].…”

Section: Discussionmentioning

confidence: 99%

Association between the rs1544410 polymorphism in the vitamin D receptor (VDR) gene and insulin secretion after gestational diabetes mellitus

et al. 2020

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Background and aims Genetic variants involved in vitamin D metabolism have been associated with diabetes and related syndromes/diseases. We wanted to investigate possible associations of polymorphisms in genes involved in vitamin D metabolism with indices of insulin resistance and insulin secretion, and also with development of diabetes after gestational diabetes mellitus (GDM). Materials and methods We have studied 376 women with previous GDM. Eight single nucleotide polymorphisms (SNPs) in the genes for vitamin D receptor (VDR) [rs731236, rs7975232, rs10735810, and rs1544410], vitamin D binding protein (DBP) [rs7041 and rs4588], and cytochrome P450 family 27 subfamily B member 1 (CYP27B1) [rs10877012 and rs4646536] were genotyped by TaqMan Allelic Discrimination Assay using the Quantstudio 7 Flex system. A 75-g oral glucose tolerance test (OGTT) was performed 1-2 years postpartum. The homeostasis model assessment of insulin resistance (HOMA-IR) and the disposition index [(insulinogenic index: I30/G30)/HOMA-IR] were used to calculate insulin resistance and insulin secretion, respectively. Serum samples for determination of 25(OH)D3 were collected at the time of the OGTT. Manifestation of diabetes was followed up to five years postpartum. Results After adjustment for BMI, age, and ethnicity, the A-allele of the VDR rs1544410 polymorphism was found to be associated with increased disposition index (difference per allele = 3.56, 95% CI: 0.4567-6.674; p = 0.03). The A-allele of the DBP rs7041 polymorphism was found to be associated with 25(OH)D3 levels (difference [in nmol/L] per allele = −5.478, 95% CI:-8.315 to −2.641; p = 0.0002), as was the T-allele of the DBP rs4588 polymorphism (OR PLOS ONE

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“…Водночас систематичні аналізи результатів досліджень впливу саплементації вітаміну D при СПКЯ поки що не дають можливості стверджувати про її клінічний ефект [52]. Можливо, це пов'язано з поліморфізмом генів, що регулюють метаболічні ефекти вітаміну D, зокрема генним поліморфізмом рецептора вітаміну D білка, зв'язуючого вітамін D, та фермента 1-α-гідроксилази [52].…”

Section: роль вітаміну D в патогенезі спкя та його кардіометаболічнихunclassified

Modern approaches to diagnostics of hyperandrogenism distributed forms in reproductive aged women

Бурка¹,

Bobrík²,

Резниченко³

et al. 2019

Reproductive Endocrinology

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О.А. БУРКА к. мед. н., доцент кафедри акушерства та гінекології №1 Національного медичного університету ім. О.О. Богомольця, науковий консультант медичної лабораторії «ДІЛА» ORCID: 0000-0003-0133-9885 М.І. БОБРИК к. мед. н., доцент кафедри ендокринології НМУ ім. О.О. Богомольця, науковий консультант медичної лабораторії «ДІЛА» ORCID: 0000-0002-7477-213X В.М. РЕЗНИЧЕНКО лікар-ендокринолог вищої категорії ДЗ «Поліклініка № 2» Державного управління справами Т.М. ТУТЧЕНКО к. мед. н., ст. науковий співробітник відділення ендокринної гінекології ДУ «Інститут педіатрії, акушерства та гінекології ім. акад. О.М. Лук'янової НАМН України», науковий консультант медичної лабораторії «ДІЛА»

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Vitamin D and cardiometabolic disorders: a review of current evidence, genetic determinants and pathomechanisms

Cited by 44 publications

References 150 publications

Şişmanlığın derecesi ile kardiyometabolik riskler ve vitamin D düzeyi arasındaki ilişki

Şişmanlığın derecesi ile kardiyometabolik riskler ve vitamin D düzeyi arasındaki ilişki

Association between the rs1544410 polymorphism in the vitamin D receptor (VDR) gene and insulin secretion after gestational diabetes mellitus

Modern approaches to diagnostics of hyperandrogenism distributed forms in reproductive aged women

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