Relationship of zinc status with depression and anxiety among elderly population

Anbari-Nogyni, Zainab; Bidaki, Reza; Madadizadeh, Farzan; Sangsefidi, Zohreh Sadat; Fallahzadeh, Hossein; Karimi-Nazari, Elham; Nadjarzadeh, Azadeh

doi:10.1016/j.clnesp.2020.02.008

Cited by 26 publications

(17 citation statements)

References 55 publications

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“…However, a cross-sectional study conducted on 297 elderly subjects indicated no significant association between dietary or serum zinc and anxiety. Noteworthy, low serum zinc levels, but not dietary zinc, were associated with higher odds of depression 44 . Differences in dietary assessment tools, sample size, and health status of the participants might be regarded as the sources of inconsistency in studies results.…”

Section: Discussionmentioning

confidence: 91%

Zinc nutritional status, mood states and quality of life in diarrhea-predominant irritable bowel syndrome: a case–control study

Rezazadegan

Shahdadian

Soheilipour

et al. 2022

Sci Rep

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Zinc is an important trace element for structure, and regulation in the central nervous system, as well as the gut homeostasis. There are several mental disorders associated with zinc deficiency. The relationship between zinc nutritional status with mood states and quality of life (QoL) in diarrhea-predominant irritable bowel syndrome (IBS-D) has not been studied yet. This case–control study aimed to investigate the association between zinc nutritional status with mood states and QoL in IBS-D patients. Sixty-one newly diagnosed patients with IBS-D and 61 matched healthy controls were enrolled. Dietary zinc intakes and serum zinc levels were measured. Mood states and QoL were evaluated by validated questionnaires. Logistic regression was used to estimate the odds of IBS-D in relation to zinc deficiency. Decreased serum zinc levels were observed in the IBS-D group than in the controls (p = 0.001). There were higher scores of depression (p = 0.014), anxiety (p = 0.005), and stress (p = 0.001) among IBS-D patients. Moreover, overall QoL, physical and psychological health were lower in IBS-D patients compared to the controls (p < 0.001). “Food avoidance” had the lowest, while the “relationship” had the highest score among the patients (51.09 ± 26.80 and 78.14 ± 23.30, respectively). Dietary zinc intake was positively correlated with psychological health in the controls (r = 0.295, p = 0.022) and with body image in the patients (r = 0.266, p = 0.044). According to the logistic regression, zinc deficiency was not significantly associated with odds of IBS-D. Findings show that zinc deficiency may be associated with some parameters of IBS-D. Further clinical studies are needed to explore the causal relationship between zinc status and IBS pathogenesis.

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Section: Discussionmentioning

confidence: 91%

Zinc nutritional status, mood states and quality of life in diarrhea-predominant irritable bowel syndrome: a case–control study

Rezazadegan

Shahdadian

Soheilipour

et al. 2022

Sci Rep

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“…These results agree with previous studies which employed both acute and chronic stress models in addition to in vitro studies using primary hepatocytes treated with synthetic glucocorticoids [ 27 , 55 , 56 , 57 ]. Furthermore, zinc deficiency has been observed in individuals suffering from anxiety and depression, whilst a zinc-deficient diet has been shown to influence the severity of depressive symptoms in women but not men [ 58 , 59 , 60 ]. We also examined the mRNA expression of major hepatic zinc-binding and transport proteins including Mtf1, Mt1a, Slc30a1 (ZnT1), and Slc39a14 (Zip14).…”

Section: Discussionmentioning

confidence: 99%

Hepatic Homeostasis of Metal Ions Following Acute Repeated Stress Exposure in Rats

et al. 2021

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Essential metals such as copper, iron, and zinc are cofactors in various biological processes including oxygen utilisation, cell growth, and biomolecular synthesis. The homeostasis of these essential metals is carefully controlled through a system of protein transporters involved in the uptake, storage, and secretion. Some metal ions can be transformed by processes including reduction/oxidation (redox) reactions, and correspondingly, the breakdown of metal ion homeostasis can lead to formation of reactive oxygen and nitrogen species. We have previously demonstrated rapid biochemical responses to stress involving alterations in the redox state to generate free radicals and the resultant oxidative stress. However, the effects of stress on redox-active metals including iron and copper and redox-inert zinc have not been well characterised. Therefore, this study aims to examine the changes in these essential metals following exposure to short-term repeated stress, and to further elucidate the alterations in metal homeostasis through expression analysis of different metal transporters. Outbred male Wistar rats were exposed to unrestrained (control), 1 day, or 3 days of 6 h restraint stress (n = 8 per group). After the respective stress treatment, blood and liver samples were collected for the analysis of biometal concentrations and relative gene expression of metal transporter and binding proteins. Exposure to repeated restraint stress was highly effective in causing hepatic redox imbalance. Stress was also shown to induce hepatic metal redistribution, while modulating the mRNA levels of key metal transporters. Overall, this study is the first to characterise the gene expression profile of metal homeostasis following stress and provide insight into the changes occurring prior to the onset of chronic stress conditions.

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“…Current evidence most strongly supports a positive association between zinc deficiency and the risk of depression (106)(107)(108). Conversely, the relationship between magnesium and selenium deficiency and depression has not been fully understood.…”

Section: Therapeutic Opportunities For Food Supplements In Depression: Evidence Limitations and Suggestions For The Futurementioning

confidence: 99%

Therapeutic Opportunities for Food Supplements in Neurodegenerative Disease and Depression

et al. 2021

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Emerging evidence is showing nutrition as a crucial factor in the high prevalence and incidence of neurodegenerative mental disorders. Preventive interventions on neuroinflammation seem to be able to interfere with neurodegeneration. Supplementation of essential nutrients, such as long-chain-polyunsaturated fatty acids, vitamin E and mineral elements, may minimize inflammation, enhancing antioxidative defense, and lowering the risk and incidence of age-related diseases, such as cardiovascular diseases and neurodegenerative diseases. This manuscript reviews the current evidence on the role of neuroinflammation in the pathophysiology of neurodegenerative and mental disorders, and preventive strategies for food supplementation in these neuropsychiatric diseases. Dietary supplementation-based strategies have been demonstrated to be effective in subjects with mild cognitive impairment, while weaker results have been obtained in patients with advance neurodegenerative disease. Adjunctive supplementation has also been demonstrated to improve depression, this being of marked benefit considering the comorbidity between cognitive impairment/dementia and depression. Further research is needed to improve the prescriptive precision of supplementation in patients, and to better understand potential interactions with clinical and pharmacokinetic factors.

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Relationship of zinc status with depression and anxiety among elderly population

Cited by 26 publications

References 55 publications

Zinc nutritional status, mood states and quality of life in diarrhea-predominant irritable bowel syndrome: a case–control study

Zinc nutritional status, mood states and quality of life in diarrhea-predominant irritable bowel syndrome: a case–control study

Hepatic Homeostasis of Metal Ions Following Acute Repeated Stress Exposure in Rats

Therapeutic Opportunities for Food Supplements in Neurodegenerative Disease and Depression

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