We analyze publications from various health scientific journals, especially the Covid-19 vaccine program, which succeeded in answering this research problem. We want the Covid-19 vaccine program among citizens in terms of challenges and expectations. Our data retrieval efforts are carried out using electronic applications on data sources based on health publications related to the Covid-19 pandemic and national vaccination programs from Esavier, Google Book, Taylor&France, Sagepub, Google Scholar, and Researchgate. Furthermore, data analysis involves a system of data evaluation, coding, and interpretation before concluding. With secondary data, we report the results; this paper chooses a descriptive and qualitative analytical approach and literature study. All stages and systems of our research design followed the researcher's direction for a descriptive qualitative review so that we were assisted in reporting the results. We can summarize the results that the vaccine program has received publicly. However, due to the government's limitations so far, public understanding of the vaccine agenda still requires national support and participation, so this is a challenge and hope in completing the Covid-19 response agenda in Indonesia.