Relationships among lipid peroxidation, glutathione peroxidase, superoxide dismutase, sperm parameters, and competitive index in dairy bulls

Kasimanickam, Ramanathan; Kasimanickam, Vanmathy; Thatcher, Craig D.; Nebel, R.L.; Cassell, B.G.

doi:10.1016/j.theriogenology.2006.11.013

Cited by 74 publications

(53 citation statements)

References 55 publications

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“…The data presented in Table 1 indicate that semen samples analyzed in this study had 62.51 ± 6.94% total motile sperm. Similar results were reported by Kasimanickam et al (2007). The evaluated semen samples were also characterized by a high percentage of progressively motile spermatozoa (PMOT, 21.46 ± 6.51%), which indicates that the analyzed semen is highly suitable for insemination.…”

Section: Resultssupporting

confidence: 85%

“…ATP concentration (15.59 ± 2.16 nmol/10 8 sperm cells) suggests the high metabolic efficiency of the analyzed semen samples. The activity levels of antioxidant enzymes -CAT, GPx and SOD (Table 1) -were similar to those reported by Kasimanickam et al (2007). Mentioned results indicates that the analyzed sperm samples are characterized with efficient enzymatic antioxidant system, which can be confirmed by the low value of the DNA Fragmentation Index.…”

Section: Resultssupporting

confidence: 81%

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Selected qualitative and biochemical parameters of cryopreserved semen of Holstein-Friesian (HF) AI bulls

Lecewicz¹,

Hering²,

Kamiński³

et al. 2015

Polish Journal of Veterinary Sciences

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Selected qualitative and biochemical parameters were determined in cryopreserved semen used for artificial insemination, sampled from 120 bulls reared at the Animal Breeding and Insemination Center in Bydgoszcz. The total average motility of the analyzed sperm samples was determined at 62.51%. The percentage of motile spermatozoa displaying progressive forward motility was 21.65%. Analyzed samples were characterized by a high percentage of sperm cells with a intact plasma membrane (71.21%) and active mitochondria (71.32%). High efficiency of the enzymatic antioxidant system of the evaluated sperm cells was demonstrated by high activity of CAT, GPx and SOD (494.37, 2847.83 and 5.31U/1x10 9 spermatozoa, respectively) values and low values of the DNA Fragmentation Index (9.32). The results of the study, obtained with the involvement of advanced analytical methods, indicate a high fertilizing capability of the analyzed sperm samples.

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Section: Resultssupporting

confidence: 85%

Section: Resultssupporting

confidence: 81%

Selected qualitative and biochemical parameters of cryopreserved semen of Holstein-Friesian (HF) AI bulls

Lecewicz¹,

Hering²,

Kamiński³

et al. 2015

Polish Journal of Veterinary Sciences

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“…Acording to previous studies there is an evidence of a negative correlation between motility and the LPO rate (Kasimanickam et al, 2007), which is consistent with the findings of the present study; it may be due to simultaneous improvment of LPO and motility for cryopreserved spermatozoa following treatments III and V.…”

Section: Discussionsupporting

confidence: 93%

Effect of rosemary (Rosmarinus officinalis) extracts and glutathione antioxidants on bull semen quality after cryopreservation

Kia

Olfati-Karaji

Hoseinkhani

et al. 2014

Span. j. agric. res.

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The present study determined the effects of the addition of rosemary extract (ROM), glutathione (GSH), and their combination (ROM + GSH) to freezing extender on the quality of bull semen after cryopreservation. Before cryoperservation, the samples were diluted in a tris-egg yolk (TEY) extender containing 5 mM GSH (treatment I), 5 or 10 g L–1 ROM (treatments II and III), and ROM with GSH (5 mM GSH with 5 or 10 g L–1 of ROM) (treatments IV and V). An extender containing no antioxidants (non-ROM/GSH-treated) served as control group. Kinematic parameters were evaluated by means of a computer-assisted semen analysis (CASA). The viability and membrane integrity of the sperm were assessed using eosin-nigrosin stain and the hypo-osmotic swelling test (HOST) at 0 and 2 h after freezethawing. Lipooxidative parameters, superoxide dismutase, and glutathione peroxidase (GPx) activity were assessed after thawing. Treatment III showed positive effects for total motility (TM) (p < 0.01), average path velocity (VAP) (p < 0.001), viability (p < 0.01) and HOST (p < 0.01); however, lipid peroxidation (LPO) decreased (p < 0.05) and GPx activity increased (p < 0.05) immediately after thawing compared to the control. The TM (p < 0.01), VAP (p < 0.01), viability (p < 0.01), HOST (p < 0.01) decreased in LPO (p < 0.01) and GPx activity (p < 0.05) for treatment V and the viability and GPx activity (p < 0.05) for treatment I were significantly higher than for the control group at 2 h after thawing. It was concluded that the inclusion of ROM and its combination with GSH improves the post-thaw quality of bull semen.

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“…The ADS in human erythrocytes with preserved homeostasis finely retunes its composition according to plasma oxidative demands. An increase in the level of a specific plasma lipid component may potentiate mem brane lipid peroxidation in erythrocytes and decrease intraerythrocyte production of O 2 .-, which could result in a negative correlation between SOD and GSH-Px activities found in some experiments (6)(7)(8)(9). The discovery of the haemoglobin-cholesterol (Hb-Ch) complex implies the way in which cholesterol may influence the organisation of ADS in erythrocytes (7).…”

Section: Introductionmentioning

confidence: 99%

Complexity of free radical Metabolism in human Erythrocytes

Nikolić‐Kokić¹,

Blagojević²,

Spasić³

2010

Journal of Medical Biochemistry

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Kratak sadr`aj: Produkcija slobodnih radikala u eritrocitima uglavnom se odnosi na nastajanje superoksid anjon radikala (O 2 .-) putem autooksidacije oksihemoglobina u methemoglobin. Ljudski eritrociti izlo`eni su prooksidacionom delovanju vodonik-peroksida nastalog dismutacijom O 2 .-ili iz cirkulacije, kao i azot oksidu (NO) iz cirkulacije. Od di rektnih reakcija slobodnih radikala, reakcija O 2 .-i NO uz nastajanje peroksinitrita je reakcija sa primarno {tetnim posledicama po eritrocite. U eritrocitima se nalaze enzimi za{tite od oksidacionih o{te}enja, kao {to su superoksid dismu taza (SOD, EC 1.15.1.1), katalaza (CAT, EC 1.11.1.6), glutation peroksidaza (GSHPx, EC 1.11.1.9) i glutation reduktaza (GR, EC 1.6.4.2) kao i komponente male mo lekulske mase (glutation, vitamini E i C). Njihovim sadej stvom se kanali{u reakcije slobodnih radikala tako da di rektna o{te -}enja biomakromolekula budu {to manja. Me|u tim, kako nema de novo sinteze enzima u maturiranim eri trocitima, kapacitet ovih sistema je ograni~en, jer slobo d noradikalske vrste i direktno inhibiraju neke od enzima. Promene na enzimima i njihova inhibicija slobodnim radi kalima uti~u na kapacitet za{tite od oksidacionih o{te}enja i relativni udeo pojedinih komponenti u ukupnom antioksi da tivnom poten cijalu. To se mo`e pratiti i preko promena aktiv nosti pojedina~nih komponenti, ali i me |u sobnih odnosa izme|u komponenti antioksidativne odbrane diskrimina cio nim sta ti sti ~kim metodama, koje ukazuju na sveukupnost i kompleksnost odnosa antioksida tivnih kompo nenti u eritro citima i njihov sistemski zna~aj.

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Relationships among lipid peroxidation, glutathione peroxidase, superoxide dismutase, sperm parameters, and competitive index in dairy bulls

Cited by 74 publications

References 55 publications

Selected qualitative and biochemical parameters of cryopreserved semen of Holstein-Friesian (HF) AI bulls

Selected qualitative and biochemical parameters of cryopreserved semen of Holstein-Friesian (HF) AI bulls

Effect of rosemary (Rosmarinus officinalis) extracts and glutathione antioxidants on bull semen quality after cryopreservation

Complexity of free radical Metabolism in human Erythrocytes

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