Relationships among regional diastolic impairment, elongation of global time to peak filling rate, and global diastolic function using ECG-gated myocardial perfusion SPECT in heart failure

Abstract

The development of regional early diastolic impairment makes g-TPF elongation and induces global dysfunction in early diastole.

Relationship between left ventricular function and wall motion synchrony in heart failure assessed by ECG-gated myocardial perfusion SPECT

“…In nuclear cardiology, GMPS has progressed to the point where it is able to estimate global LV function, but it is not yet fully capable of estimating LV systolic/diastolic wall motion synchrony. We developed a novel program to evaluate regional LV wall motion [9][10][11][12]. However, until now we have not fully clarifi ed the relationship between LV dyssynchrony and its dysfunction and the difference between synchrony in IHD and OHD using our program with GMPS.…”

“…Systolic and diastolic temporal parameters have been also validated by comparison with those assessed by speckle-tracking imaging derived from echocardiography [10]. The relationship between diastolic dysfunction and LV heterogeneous dilatation has been clarifi ed using this program [11] and systolic/diastolic dyssynchrony was evaluated and compared among New York Heart Association (NYHA) functional classes in HF [12]. In this article, the relationship between LV function and synchrony was confi rmed and differences between synchrony in HF patients with or without IHD were also examined.…”