2005
DOI: 10.1016/j.ygcen.2004.12.003
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Relationships between aromatase and estrogen receptors in the brain of teleost fish

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Cited by 138 publications
(116 citation statements)
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“…Teleosts have extraordinarily high brain aromatase activity levels, especially in the forebrain, which exhibits levels 100-1000 times greater than that found in other vertebrates (Pellegrini et al, 2005;Forlano et al, 2006) and glial cells are the main source for brain aromatase in teleosts (Forlano et al, 2006). Aromatase activity was significantly higher in the forebrain of black porgy at 120 dph compared to 90 dph and is in agreement with previous report (Lee et al, 2004).…”
Section: Discussionsupporting
confidence: 90%
See 1 more Smart Citation
“…Teleosts have extraordinarily high brain aromatase activity levels, especially in the forebrain, which exhibits levels 100-1000 times greater than that found in other vertebrates (Pellegrini et al, 2005;Forlano et al, 2006) and glial cells are the main source for brain aromatase in teleosts (Forlano et al, 2006). Aromatase activity was significantly higher in the forebrain of black porgy at 120 dph compared to 90 dph and is in agreement with previous report (Lee et al, 2004).…”
Section: Discussionsupporting
confidence: 90%
“…The biological significance for elevated aromatase levels, and thus the high production of neural estrogens in teleosts, is still unresolved. Neuroestrogens in teleosts have been proposed to contribute to their continual neurogenesis throughout life (Menuet et al, 2003;Pellegrini et al, 2005). q-PCR analysis of pcna transcripts in black porgy brain showed normal proliferation throughout development, which can be correlated to the plasticity characterizing teleost brain (Zikopoulos et al, 2000;Ekström et al, 2001).…”
Section: Discussionmentioning
confidence: 94%
“…The opposite trends between effects on plasma hormone concentrations (inhibition) and gene-expression profiles along the HPG axis (predominantly induction) were indicative of compensatory mechanisms. Furthermore, since PCZ down-regulated brain CYP19B expression and expression of CYP19B is regulated by E2 through binding to the estrogen responsive element (ERE) on its promoter in vitro and in vivo (28) and the concentration of E2 was significantly decreased, the lesser concentration of E2 in fish exposed to PCZ could be a primary reason for the observed down-regulation of CYP19B.…”
Section: Discussionmentioning
confidence: 99%
“…The exact physiological significance of brain CYP19A2 expression has not been determined, but recent work has suggested its role in estrogen dependent neurogenesis (which continuous through adulthood in fish) (Forlano et al, 2001;Pellegrini et al, 2005Pellegrini et al, , 2007, sex change and behavior (Marsh et al, 2006), and regulation of the gonadal-pituitary-hypothalamic feedback loop (Melo and Ramsdell 2001;Villeneuve et al, 2007). Additional studies with estrogenic inducers and aromatase inhibitors together with measurement of CYP19A2 expression and phenotypic effects (for example (Greytak et al, 2005;Kishida et al, 2002)) will further refine the physiological significance of aromatase in fish.…”
Section: Discussionmentioning
confidence: 99%