Relationships between bone geometry, volumetric bone mineral density and bone microarchitecture of the distal radius and tibia with alcohol consumption

Paccou, Julien; Edwards, Mark H.; Ward, Kate; Jameson, Karen; Moon, Rebecca J; Dennison, Elaine; Cooper, Cyrus

doi:10.1016/j.bone.2015.05.002

Cited by 23 publications

(16 citation statements)

References 39 publications

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“…Unfortunately, no routine, noninvasive method for evaluating bone in humans provides insight into bone quality. However, a recent study evaluated the relationship between current alcohol consumption and bone in the distal radius and tibia in aged men and women using high‐resolution computed tomography (Paccou et al., ). Moderate to heavy alcohol consumption was associated with minimal changes in bone geometry, density, and microarchitecture.…”

Section: Alcohol and Bonementioning

confidence: 99%

Alcohol: A Simple Nutrient with Complex Actions on Bone in the Adult Skeleton

Gaddini

Turner

Grant

et al. 2016

Alcoholism Clin & Exp Res

124

101

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Background Alcohol is an important nonessential component of diet, but the overall impact of drinking on bone health, especially at moderate levels, is not well understood. Bone health is important because fractures greatly reduce quality of life and are a major cause of morbidity and mortality in the elderly. Regular alcohol consumption is most common following skeletal maturity, emphasizing the importance of understanding the skeletal consequences of drinking in adults. Method This review focuses on describing the complex effects of alcohol on the adult skeleton. Studies assessing the effects of alcohol on bone in adult humans as well as skeletally-mature animal models published since the year 2000 are emphasized. Results Light to moderate alcohol consumption is generally reported to be beneficial, resulting in higher bone mineral density (BMD) and reduced age-related bone loss, whereas heavy alcohol consumption is generally associated with decreased BMD, impaired bone quality and increased fracture risk. Bone remodeling is the principle mechanism for maintaining a healthy skeleton in adults and dysfunction in bone remodeling can lead to bone loss and/or decreased bone quality. Light to moderate alcohol may exert beneficial effects in older individuals by slowing the rate of bone remodeling but the impact of light to moderate alcohol on bone remodeling in younger individuals is less certain. The specific effects of alcohol on bone remodeling in heavy drinkers is even less certain because the effects are often obscured by unhealthy lifestyle choices, alcohol-associated disease, and altered endocrine signaling. Conclusions Although there have been advances in understanding the complex actions of alcohol on bone, much remains to be determined. Limited evidence implicates age, skeletal site evaluated, duration and pattern of drinking as important variables. Few studies systematically evaluating the impact of these factors have been conducted and should be made a priority for future research. In addition, studies performed in skeletally mature animals have potential to reveal mechanistic insights into the precise actions of alcohol and associated co-morbidity factors on bone remodeling.

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Section: Alcohol and Bonementioning

confidence: 99%

Alcohol: A Simple Nutrient with Complex Actions on Bone in the Adult Skeleton

Gaddini

Turner

Grant

et al. 2016

Alcoholism Clin & Exp Res

124

101

View full text Add to dashboard Cite

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“…Similarly, the highest aBMD was exhibited in postmenopausal women (mean 62.8 ages) who drank 2-3 times per week compared to the non-drinkers [19]. In terms of volumetric BMD (vBMD, g/cm 3 ) measured by high-resolution peripheral quantitative computed tomography, Paccou et al [17] found that men (mean 76.1 years) who consumed low amounts of alcohol had a lower vBMD, but women (mean 76.5 years) with moderate/high alcohol intake had a significantly higher vBMD. Our study did not find differences in aBMD of the lumbar spine, but lighter drinkers (1-9 g/day) exhibited higher aBMD of the lumbar spine in elderly women (50 to 79 years) compared to non-drinkers [16].…”

Section: Discussionmentioning

confidence: 96%

“…All of these factors can interplay to produce conflicting results on human skeletons. Unfortunately, most of the previous studies investigating the relationship between alcohol consumption and areal bone mineral density (aBMD) have focused on either middle-aged/older men and/or middle-aged/postmenopausal women [16][17][18][19][20]. Very few studies have examined the relationship between alcohol and bone in young adults [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Bone-Loading Physical Activity and Alcohol Intake but not BMI Affect Areal Bone Mineral Density in Young College-Aged Korean Women: A Cross-Sectional Study

Sung

Singh

et al. 2019

IJERPH

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The purpose of this cross-sectional study was to determine the differences in areal bone mineral density (aBMD) based on alcohol consumption behaviors, bone-loading history as assessed by a bone-specific physical activity questionnaire (BPAQ), and the body mass index (BMI). College-aged female students (N = 112) were recruited from the universities in Seoul and Gyeonggi province, South Korea. The aBMD of the lumbar spine and non-dominant side of the proximal femur (total hip, TH; femoral neck, FN; femoral trochanter, FT) were measured using dual energy X-ray absorptiometry (DXA). Alcohol consumption was determined by the frequency and amount of alcohol intake during the past 12 months using a self-reported questionnaire. The X-scan plus II was used to measure height (cm), body mass (kg), fat-free mass (FFM, kg), and % body fat. Drinking two or more times alcohol per week was associated with greater aBMD of the TH (p = 0.04–0.002) and FN (p = 0.043) compared to a lower frequency of alcohol consumption and 2–4 times per month, respectively. Based on the drinking amount per occasion, there were no significant group differences (p > 0.05) in aBMD at any of the sites. The highest group of total BPAQ had greater aBMD of the TH, FN, and FT versus the lowest (p = 0.023–0.009) and mid of total BPAQ groups (p = 0.004–0.009). Additionally, the highest group had greater aBMD of the lumbar spine compared to the mid group (p = 0.001). No significant group differences in aBMD at any of the sites were noted based on the BMI (p > 0.05). Young college-aged women with greater bone-loading physical activity showed greater aBMD at the TH, FN, FT, and lumbar spine, while a moderate alcohol intake was associated with greater aBMD of the TH and FN. These findings have clinical implications for young women who may not participate in high-impact physical activity and are binge drinkers.

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“…Globally, it is one of the major causes of osteoporosis in men (Giusti & Bianchi, ; Kim et al, ; Misiorowski, ). Higher use has been shown to decrease BMD (Alvisa‐Negrín et al, ; Lairinen, Lamberg‐Allardt, Tunninen, Harkonen, & Valimaki, ; Malik et al, ; Maurel, Boisseau, Benhamou, & Jaffre, ; Paccou et al, ; Ulhøi, Meldgaard, Steiniche, Odgaard, & Vesterby, ), and increase the number of empty osteocyte lacunae (Maurel et al, ). With continued high consumption, men may be more susceptible to BMD decrements than their female counterparts (Kanis et al, ; Malik et al, ).…”

Section: Discussionmentioning

confidence: 99%

Use of backscattered scanning electron microscopy to quantify the bone tissues of mid‐thoracic human ribs

Beresheim

Pfeiffer

Grynpas

et al. 2019

American J Phys Anthropol

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Objectives: Novel information on apartheid health conditions may be obtained through the study of recent skeletal collections. Using a backscattered scanning electron microscopy (BSE-SEM) approach, this study aims to produce bone quality and tissue mineralization data for an understudied South African population from the Western Cape province.Methods: Using BSE-SEM imaging, cortical porosity (Ct.Po), osteocyte lacunar density (Ot.Lc. Dn), and the degree of tissue mineralization were quantified in mid-thoracic ribs from the Kirsten Skeletal Collection. Individuals ( n female = 75, n male = 68, and mean age = 46.3 years)were predominantly from the South Africa Colored (SAC) population group ( n SAC = 103, 72%).Full cross-sectional images of each rib were manually stitched together in Adobe Photoshop.Photomontages were imported into MATALB (Mathworks, Natick, MA) for image processing and analysis. Age-related changes in histomorphometric parameters and sex differences were examined using correlation analysis, as well as linear and nonlinear regressions.Results: Young adult men have significantly less mineralized bone and fewer osteocyte lacunae, compared to women. Only men demonstrate a significant negative relationship between Ot.Lc.Dn and age. Average tissue mineralization decreases with age in women, while Ct.Po increases.Pore area (Po.Ar) does not vary with age, but pore density (Po.Dn) is highest in the perimenopause, when accelerated rates of bone turnover are first anticipated. Ct.Po is highest in the years following the predicted age of menopause, but levels off in the final decades of life.Conclusions: Men and women display disparate patterns of bone aging. Systemic disenfranchisement of non-white population groups affected bone health in South Africa, and may continue to do so today. Indicators of poor bone quality are evident in the full study sample, indicating that osteoporosis and fracture risk are not just of concern to the aged white female population. K E Y W O R D Sbone histomorphometry, BSE-SEM, osteoporosis, South African apartheid

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Relationships between bone geometry, volumetric bone mineral density and bone microarchitecture of the distal radius and tibia with alcohol consumption

Cited by 23 publications

References 39 publications

Alcohol: A Simple Nutrient with Complex Actions on Bone in the Adult Skeleton

Alcohol: A Simple Nutrient with Complex Actions on Bone in the Adult Skeleton

Bone-Loading Physical Activity and Alcohol Intake but not BMI Affect Areal Bone Mineral Density in Young College-Aged Korean Women: A Cross-Sectional Study

Use of backscattered scanning electron microscopy to quantify the bone tissues of mid‐thoracic human ribs

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