Relationships between medication intake, complaints of dry mouth, salivary flow rate and composition, and the rate of tooth demineralization in situ

Bardow, Allan; Nyvad, Bente; Nauntofte, Birgitte

doi:10.1016/s0003-9969(01)00003-6

Cited by 211 publications

(150 citation statements)

References 20 publications

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“…The drugs commonly used in the treatment of some disorders cause hyposalivation, what can take, in the same manner, to an increase of the dental caries experience [21]. In this same study [22], the authors concluded that, independently of the reduction detection or not of the salivary flow, all patients that used chronic medications must receive major dental care, including oral hygiene instruction to children and their caretakers, dietary advice, and topical application of fluoride.…”

Section: Discussionmentioning

confidence: 99%

Experience of Dental Caries and Use of Continuous Medication in Children with Neuropsychomotor Disorders

Hartwig¹,

Ferreira²,

Costa³

et al. 2016

Pesqui. bras. odontopediatria clín. integr.

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Objective: To identify the relation between the use of continuous medication by children with neuropsychomotor disorders and the development of the dental caries disease. Material and Methods: The data were obtained from medical and dental records of children, who were assisted in an extension project of the Dentistry School of the Federal University of Pelotas. Socio-economic variables, the disability diagnosis, the type and frequency of the continuous medication, and the dental caries experience registered in the dental record were collected. The data were evaluated by double typing, analyzed by descriptive statistics, and the associations were tested by the Quisquared, Fisher exact, Mann-Whitney, and Kruskal-Wallis tests. The Stata Statistical Software, version 12.0, was utilized considering the level of significance of 5%. Results: 119 records were evaluated, and the results were distributed by age bracket due to the high age range. Undoubtedly, the cerebral palsy was the most prevalent (33.9%). From the total of the children, 68.8% were using continuous medication, and the majority (56%) uses medication there are more than 24 months. The anticonvulsants were the most used medications (33.8%), and 96.5% of the children used medication during the nocturnal period. Half of the utilized medications presented sucrose in its composition. Conclusion: A statistically significant association between the use of continuous medication, containing sucrose, and the dental caries experience were not observed, what suggests that other risk factors contribute to the disease installation.

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Section: Discussionmentioning

confidence: 99%

Experience of Dental Caries and Use of Continuous Medication in Children with Neuropsychomotor Disorders

Hartwig¹,

Ferreira²,

Costa³

et al. 2016

Pesqui. bras. odontopediatria clín. integr.

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“…Saliva stimulation influences the protein composition, in particular the type of secreted proteins and their concentration 1,17,63 . Unstimulated saliva is composed of several proteins including α-amylase, serum albumin, immunoglobulin, and mucin, which make up for 20-30% of the protein content 64 .…”

Section: Discussionmentioning

confidence: 99%

Rheological Behavior of Food Emulsions Mixed with Saliva: Effect of Oil Content, Salivary Protein Content, and Saliva Type

et al. 2008

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In this paper, we studied the effect of saliva on the rheological properties of β-lactoglobulin-and lysozyme-stabilized emulsions, prepared at pH=6.7 in relation to variation of emulsions-and saliva-related parameters. The effect of oil-volume fraction (2.5% w/w to 10% w/w), salivary protein concentration (0.1 to 0.8 mg ml −1 ), and the use of both stimulated and unstimulated saliva was investigated. Viscosity and storage modulus were measured before (η emul and G′ emul , respectively) and after addition of saliva (η mix and G′ mix ). To better estimate the changes due to saliva-induced flocculation of the emulsions, the ratios η mix /η emul , G′ mix /G′ emul were calculated. In addition, tan δ (=the ratio of the loss and storage moduli) was investigated to evaluate the viscoelastic behavior of the emulsion/saliva mixtures. Increasing the oil-volume fraction and salivary protein concentration resulted in an increase in η mix /η emul and G′ mix /G′ emul , while a decrease in tan δ of the emulsion/ saliva mixtures is occurring. When compared with unstimulated saliva, mixing β-lactoglobulin-stabilized emulsions with stimulated saliva led to a reduction in η mix / η emul and G′ mix /G′ emul , and an augment of tan δ at all measured deformations. In case of lysozyme-stabilized emulsions, the use of stimulated saliva increased G′ mix / G′ emul for +<3 when compared to unstimulated saliva. The effect of stimulated saliva on the η mix /η emul and tan δ in this mixture is similar to that of unstimulated saliva. These results indicate that the influence of stimulated saliva on the rheological parameters of emulsion/saliva mixtures largely depends on the type of emulsions. To conclude, our findings demonstrate that the rheological behavior of emulsions upon mixing with saliva is greatly affected by both saliva and emulsion properties.

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“…As with avalanches in winter mountains it is hard to say that a single factor of lesion progression is responsible for cavity formation, and it could easily be asked: is the shift in bacterial activity due to quorum sensing responsible, is the change in host responses due to saliva factors responsible, is temporary overload of low mo-lecular carbohydrates responsible, is insufficient oral hygiene responsible, or is any other factor causing progression responsible? It could also be looked at the influence of drug-induced hyposalivation as one of the main factors of root caries progression in the elderly [24]. Seemingly, it is a well-known scenario in patients attending for their routine dental check-ups to see individuals under antihypertensive and/or tranquilizing medication to develop hidden approximal or root dentine lesions within a very short time after decades of robust caries inactivity.…”

Section: The Avalanche Caries Progression Modelmentioning

confidence: 99%

New insights in understanding dental caries and periodontal disease: the avalanche model

Gaengler¹,

Marković²,

Norden³

et al. 2009

Health

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Biology is based on evolution; therefore, eucariotes like plants, animals and human beings are living in harmony with their procariote ancestors. If this is obviously the normal way of life, then pathobiology follows the same basic principles. The highly complex harmony of the living world may be disrupted, and a punctuated disease starts which is different from the health equilibrium. To reflect this biological archetype on the main diseases in dentistry -caries and periodontitis -the avalanche model is being proposed based on scientific and clinical evidence. This way of argumentation does influence the strategic planning of preventive and curative programmes in dental research as well as in daily practise.

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Relationships between medication intake, complaints of dry mouth, salivary flow rate and composition, and the rate of tooth demineralization in situ

Cited by 211 publications

References 20 publications

Experience of Dental Caries and Use of Continuous Medication in Children with Neuropsychomotor Disorders

Experience of Dental Caries and Use of Continuous Medication in Children with Neuropsychomotor Disorders

Rheological Behavior of Food Emulsions Mixed with Saliva: Effect of Oil Content, Salivary Protein Content, and Saliva Type

New insights in understanding dental caries and periodontal disease: the avalanche model

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