Relationships between n-acetylneuraminic acid, serotonin and amphetamines on the isolated rat stomach preparation

Vaccari, Andrea; Cugurra, F

doi:10.1016/0006-2952(68)90129-9

Cited by 7 publications

(2 citation statements)

References 9 publications

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“…Consequently, we have undertaken a detailed examination of the structure of 2.S S NGF, the fundamental unit possessing NGF activity, as the first step in establishing the structurefunction relationships of this factor. 99 Subunit Structure Earlier observations of Zanini et al (18) indicated that 2.5 S NGF, as prepared by the method of Bocchini and Angeletti (5), underwent dissociation to yield molecules that possessed only half the apparent molecular weight of the native molecule (28,000).However, these 14,000 molecular weight species were indistinguishable from native NGF with regard to both biological and immunochemical properties. Consequently, experiments to determine the number and kinds of polypeptide chains comprising 2.5 S NGF were carried out.…”

Section: The Biological Properties Of B-ngfmentioning

confidence: 99%

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Functional and Structural Proteins of the Nervous System

Mandel¹

1972

Advances in Experimental Medicine and Biology

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Section: The Biological Properties Of B-ngfmentioning

confidence: 99%

“…Denervation of rat diaphragm muscle caused an increase in the incorporation of glucosamine into glycoproteins of the muscle tissue (45). The possible role of glycoproteins in the serotonin receptor has received additional study (99,100).…”

Section: Function Of the Glycoproteinsmentioning

confidence: 99%

Functional and Structural Proteins of the Nervous System

Mandel¹

1972

Advances in Experimental Medicine and Biology

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Biochemistry, Function, and Neuropathology of the Glycoproteins in Brain Tissue

Brunngraber

1972

Advances in Experimental Medicine and Biology

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General Pharmacology of Amphetamine-Like Drugs

Änggård¹,

Lewander²,

Gunne³

1973

Drug Addiction II

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Amphetamine and related central stimulant drugs are derivatives of ß-phenylethylamine (Table 1) and are thus relatively simple organic bases. The general ßphenylethylamine skeleton is one which amphetamine shares with the neurotransmitters noradrenaline, adrenaline, and dopamine. Phenylethylamine itselfhas central stimulant properties, but has an extremely short half-life in the body due to rapid metabolism by monoamine oxidase (MAO). Amphetamine has, due to steric hindrance by the ex-methyl group, much less affinity for MAO and therefore has a longer half-Iife.Most amphetamines have cardiovascular, psychomotor stimulant, hyperthermic, and anorexigenic actions. All of the structural features of amphetamine are important far its spectrum of pharmacologic activity. Any alteration may enhance, diminish, or attenuate one or several components in the actions of the parent drug. (1) Substitution of the phenyl ring, (2) alteration of the length of the side chain, (3) substitution on the primary nitrogen group, (4) substitution of the ex-and ß-carbon atoms, and (5) their absolute configuration have been studied and will be briefly discussed here. For a more thorough review on the subject the reader is referred to the papers by BIEL (1970), vANRossuM and SIMONS (1969) and VREE (1973. The effect of ring and side-chain substitution on distribution and elimination of the amphetamines has been discussed by BECKETT and BROOKES (1970). recently reviewed the biochemical pharmacology of the amphetamines. The metabolism and disposition of methylphenidate were reported by F ARAJ et al.

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Relationships between n-acetylneuraminic acid, serotonin and amphetamines on the isolated rat stomach preparation

Cited by 7 publications

References 9 publications

Functional and Structural Proteins of the Nervous System

Functional and Structural Proteins of the Nervous System

Biochemistry, Function, and Neuropathology of the Glycoproteins in Brain Tissue

General Pharmacology of Amphetamine-Like Drugs

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