Relationships Between Obsessive-Compulsive Symptomatology and Severity of Psychosis in Schizophrenia

Obsessive compulsive symptoms in patients with Schizophrenia on Clozapine and with Obsessive Compulsive disorder: A comparison study

“…Obsessing appears to be highly correlated with Unusual thought Content and this does not appear to be mediated by either anxiety or treatment with Clozapine. Previous research has indicated that the relationship between self-reported OC symptoms and positive symptoms appears complex [2,15,23].…”

Neuropsychological profile of schizophrenia with and without obsessive compulsive disorder

“…Clinically, schizo-obsessive disorder compared to schizophrenia without OCD/OCS is associated with an earlier onset of schizophrenia (Fenton and McGlashan, 1986), more severe psychosis (Kayahan et al, 2005) and depression (Kayahan et al, 2005), greater positive (Cunill et al, 2009;Hwang et al, 2000;Lysaker et al, 2000;Tibbo et al, 2000) and negative symptoms on the PANSS (Cunill et al, 2009;Hwang et al, 2000;Lysaker et al, 2002;Nechmad et al, 2003), a poorer prognosis (Berman et al, 1995;Fenton and McGlashan, 1986;Poyurovsky et al, 2001) and treatment outcome (Berman et al, 1995;Fenton and McGlashan, 1986;Lysaker et al, 2004;Poyurovsky et al, 2001) and greater levels of agitation and extra-pyramidal side effects when treated with selective serotonin reuptake inhibitors (SSRIs) (Berman et al, 1995;Bermanzohn et al, 2000;Lindenmayer et al, 1990;Montgomery et al, 1993;Mukhopadhaya et al, 2009;Poyurovsky et al, 1999). Some studies have found no difference between schizo-obsessive disorder and schizophrenia with respect to severity of both negative and positive symptoms of schizophrenia (Byerly et al, 2005;Rajkumar et al, 2008;Poyurovsky et al, 2006).…”

Obsessive-Compulsive Disorder, Psychosis, and Bipolarity: A Longitudinal Cohort and Multigenerational Family Study

“…[10][11][12] Clinically, the presence of OCD or OCS in schizophrenia spectrum disorders is associated with poorer cognitive functioning, increased levels of depression, more severe positive and negative symptoms, poorer social functioning, and higher rates of hospitalization. [13][14][15][16] Though less studied, the prevalence of comorbid bipolar disorder in OCD samples is also substantial (13%-23%) and may be associated with a more episodic course of OCD, increased severity, comorbidity, suicide risk, and overall impairment. 7,8,[17][18][19][20] The clinical management of such comorbidities is often complex because it requires careful optimization of medication regimes.…”