Relationships Between Organ Weight and Body/Brain Weight in the Rat: What Is the Best Analytical Endpoint?

Bailey, Steven A.; Zidell, Robert H.; Perry, Richard

doi:10.1080/01926230490465874

Cited by 366 publications

(242 citation statements)

References 31 publications

Supporting

Mentioning

228

Contrasting

Unclassified

Order By: Relevance

“…Our findings may support the view that, in toxicology studies, analysis of relative organ weights and body weight gains may be an important endpoint for identification of potentially harmful effects of chemicals even though morphological changes are absent (1).…”

Section: Discussionsupporting

confidence: 78%

Magnesium supplements affect selected cadmium toxic actions and uptake of repeated doses of cadmium

Grosicki

Małagocki

Kycko

et al. 2015

Bulletin of the Veterinary Institute in Pulawy

View full text Add to dashboard Cite

The importance of magnesium supplements on organ retention of cadmium and allometric parameters after repeated exposure to cadmium chloride were studied in male Wistar rats. Magnesium chloride was given via drinking water (500 mg Mg/L) to rats exposed intragastrically to cadmium chloride (labelled with cadmium 109) at a daily dose corresponding to 25 mg/kg diet for 7, 14, 21, and 28 d. Supplements of magnesium temporarily decreased cadmium retention in the duodenum and liver. No significant differences in cadmium retention were evidenced in the kidneys and testicles. The supplements of magnesium also retain more of the body weight gains and restore the relative liver and testicle weight in rats intoxicated with cadmium. Comparison of the present results with earlier reports suggests a relationship between doses of magnesium and cadmium; higher doses of cadmium need more magnesium to overcome toxic action of the heavy metal.

show abstract

Section: Discussionsupporting

confidence: 78%

Magnesium supplements affect selected cadmium toxic actions and uptake of repeated doses of cadmium

Grosicki

Małagocki

Kycko

et al. 2015

Bulletin of the Veterinary Institute in Pulawy

View full text Add to dashboard Cite

show abstract

“…Instead, they may have been the result of normal variation in liver weight related to potential malnutrition due to the high PFBS concentrations in the feed (USEPA 2002;Bailey et al 2004). Based on the body weight endpoints from the acute studies, the NOAECs for quail and mallards were 3,160 and 5,620 mg PFBS/kg, ww feed, respectively.…”

Section: Discussionmentioning

confidence: 99%

Acute and Chronic Effects of Perfluorobutane Sulfonate (PFBS) on the Mallard and Northern Bobwhite Quail

Newsted

Beach²,

Gallagher³

et al. 2007

Arch Environ Contam Toxicol

View full text Add to dashboard Cite

Perfluorobutane sulfonate (PFBS) can be a final degradation product of perfluorobutane sulfonyl fluoride (PBSF)-based chemicals. Surfactants based on this chemistry are potential replacements for perfluorooctane sulfonate (PFOS)-related products and have many potential applications in industrial and commercial processes and applications. To evaluate the potential hazard that PFBS may pose to avian species, acute dietary studies with juvenile mallards and northern bobwhite quail, as well as a quail dietary chronic study of reproduction were conducted. In the acute studies, 10-day-old mallards and quail were exposed to nominal dietary concentrations of 1,000, 1,780, 3,160, 5,620 or 10,000 mg PFBS/kg feed, wet weight (ww) for 5 days and the birds were then fed an untreated diet and observed for up to 17 days. No treatment-related mortalities were observed in the study up to 10,000 mg PFBS/kg, ww feed. Body weight gains of quail exposed to 5620 or 10,000 mg PFBS/kg feed were statistically less than that of unexposed controls. Weight gain of mallards exposed to 10,000 mg PFBS/kg feed was statistically less than that of controls. There were no statistically significant effects on feed consumption of either species. In the acute studies, no observed adverse effect concentration (NOAEC) for mallards and quail were 5620 and 3160 mg PFBS/kg, ww feed, respectively. In a reproduction study, adult quail were exposed to nominal dietary concentrations of 100, 300, or 900 mg PFBS/kg, ww feed for up to 21 weeks. There were no treatment-related mortalities or effects on body weight, weight gain, feed consumption, histopathology measures, or reproductive parameters evaluated in the study when compared to the control group. Concentrations of PFBS in blood serum, liver, and eggs were dose-dependent but were less than the administered dose, indicating biodiminution. Based on the results from the quail reproduction study, the dietary NOAEC was 900 mg PFBS/kg, ww feed (equivalent to an ADI of 87.8 mg PFBS/kg bw/d).

show abstract

“…The alteration of body weight gain and organ weights of the treatment groups compared to the control group would reflect the toxicity of the substance [7]. Significant difference in organ weights between the treatment and control group may occur in the absence of any morphological changes [8]. However, there were no significance difference in organ weight showed with the result of the statistic analysis in which p≥0.05.…”

Section: Resultsmentioning

confidence: 76%

Acute Toxicity Studies of Brucea javanica Merril Leaves Extract on Mice

Angelina¹,

Dewijanti²,

Banjarnahor³

et al. 2012

JTLS

View full text Add to dashboard Cite

The objective of the study was to evaluate the oral acute toxicity of Brucea javanica Merril extract on both Male and Female DDY-Mice. Brucea javanica leaves function as a cytotoxic, anti-diarrhoea, etc. Brucea javanica leaves extract was administered orally for the first 24 hours at various dose levels (562.5 mg/kg bw (body weight), 1125 mg/kg bw, 2250 mg/kg bw, and 4500 mg/kg bw) to determine the toxicity effects. The treatment groups were compared to the normal control. Vital organs (liver, heart, lymph, lungs, etc) and body weight were analyzed to study the toxicity. LD50 was determined using Reed and Munich formula. Vital organs average weight showed no difference between the control group and the treatment groups from the lowest dose until the highest dose. In addition, the body weight data showed no difference between the control group and the treatment groups. LD50 for Brucea javanica extract using Reed and Munich formula was 1003.65 mg/kg bw. The result of the study showed that the extract was categorized as "slightly toxic".

show abstract

Relationships Between Organ Weight and Body/Brain Weight in the Rat: What Is the Best Analytical Endpoint?

Cited by 366 publications

References 31 publications

Magnesium supplements affect selected cadmium toxic actions and uptake of repeated doses of cadmium

Magnesium supplements affect selected cadmium toxic actions and uptake of repeated doses of cadmium

Acute and Chronic Effects of Perfluorobutane Sulfonate (PFBS) on the Mallard and Northern Bobwhite Quail

Acute Toxicity Studies of Brucea javanica Merril Leaves Extract on Mice

Contact Info

Product

Resources

About