Relationships between perceived workload, stress and oxidative DNA damage

Irie, Masahiro; Asami, Shinya; Shoji, Nobuyuki; Miyata, Masakazu; Kasai, Hiroshi

doi:10.1007/s004200000209

Cited by 127 publications

(82 citation statements)

References 23 publications

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“…Oxidative stress damages DNA, protein, lipids, and other macromolecules in many tissues, with telomeres (discussed below) [126] and the brain [90] being particularly sensitive. Elevated plasma and/or urine oxidative stress markers (e.g., increased F2-isoprostanes and 8-hydroxydeoxyguanosine along with decreased antioxidant compounds, such as Vitamins C and E) have been reported in individuals with depression and in those with chronic psychological stress, [27,29,127,128] and the concentration of peripheral oxidative stress markers is positively correlated with the severity and chronicity of depression, [29,129,130] as well as with evidence of accelerated apoptosis in polymorphonuclear blood cells. [131] Furthermore, the ratio of serum oxidized lipids (F2-isoprostanes) to antioxidants (Vitamin E) is directly related to psychological stress, and is inversely related to telomere length and telomerase activity (both discussed below) in chronically stressed caregivers.…”

Section: Immune Functionmentioning

confidence: 99%

Depression gets old fast: do stress and depression accelerate cell aging?

et al. 2010

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Section: Immune Functionmentioning

confidence: 99%

Depression gets old fast: do stress and depression accelerate cell aging?

et al. 2010

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“…Most notably, in vitro, oxidative stress can shorten telomeres and antioxidants can decelerate shortening (9,10). Perceived stress has been linked to one measure of oxidative DNA damage in leukocytes in women (11,12). Given these observed links, we hypothesized that chronic psychological stress may lead to telomere shortening and lowered telomerase function in peripheral blood mononuclear cells (PBMCs) and to oxidative stress.…”

mentioning

confidence: 99%

Accelerated telomere shortening in response to life stress

Epel

Blackburn

Lin

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

2,590

1,986

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Numerous studies demonstrate links between chronic stress and indices of poor health, including risk factors for cardiovascular disease and poorer immune function. Nevertheless, the exact mechanisms of how stress gets ''under the skin'' remain elusive. We investigated the hypothesis that stress impacts health by modulating the rate of cellular aging. Here we provide evidence that psychological stress-both perceived stress and chronicity of stress-is significantly associated with higher oxidative stress, lower telomerase activity, and shorter telomere length, which are known determinants of cell senescence and longevity, in peripheral blood mononuclear cells from healthy premenopausal women. Women with the highest levels of perceived stress have telomeres shorter on average by the equivalent of at least one decade of additional aging compared to low stress women. These findings have implications for understanding how, at the cellular level, stress may promote earlier onset of age-related diseases.psychological stress ͉ telomere length ͉ telomerase ͉ oxidative stress

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“…Todos estos factores, que pueden ser productos de la violencia, se han visto relacionados con malnutrición en niños (14,(24)(25)(26)(27) . Por otro lado, el estrés al que están sometidos los niños que viven en estos hogares puede llevar a estados de alta actividad inflamatoria y prooxidante, como fue observado en 2010 por Houphouet (28) , donde la malnutrición estuvo asociada con estado inflamatorio, indicado por aumento de proteína C reactiva, la cual, además, se acompañaba de depleción proteica, especialmente de albúmina, lo que podría ser un factor contribuyente a la desnutrición (29,30) . Es importante resaltar ciertas limitaciones y fortalezas del presente estudio.…”

Section: Discussionunclassified

Asociación entre violencia contra la mujer ejercida por la pareja y desnutrición crónica en sus hijos menores de cinco años en Perú

Ruíz-Grosso

Mola

Miranda

2014

Rev Peru Med Exp Salud Publica

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RESUMENObjetivos. Evaluar la asociación entre violencia contra la mujer ejercida por su pareja y la prevalencia de desnutrición crónica en sus hijos menores de cinco años. Materiales y métodos. Análisis secundario transversal de la Encuesta Demográfica y de Salud Familiar (ENDES) del año 2011, realizada en el Perú y con representatividad nacional. La variable dependiente fue desnutrición crónica en el último hijo menor de cinco años. Las variables independientes fueron el autorreporte de violencia emocional, violencia física (leve o severa) y violencia sexual, ejercidas por el último compañero o esposo de la madre en los últimos 12 meses. Realizamos análisis univariados y multivariables utilizando modelos generalizados lineales (regresión log-binomial), teniendo en cuenta la naturaleza compleja de la muestra. Se ajustaron los modelos para variables sociodemográficas y de salud madre hijo. Se calcularon razones de prevalencias (RP) e intervalos de confianza al 95%. Resultados. Se analizaron datos de 5154 madres e hijos. La prevalencia de desnutrición crónica fue de 19,8% (IC 95%: 18,1-21,6). En el análisis multivariable se encontró una mayor prevalencia de desnutrición crónica en los hijos de madres con historia de violencia física severa RP 1,27% (IC 95%: 1,09-1,48). No hubo evidencia de asociación entre la prevalencia de desnutrición crónica y los otros tipos de violencia ejercida por la pareja. Conclusiones. El reporte de violencia física severa en el último año, por parte de las madres, estuvo asociado a un aumento en la prevalencia de desnutrición crónica en sus niños menores de cinco años. Palabras clave: Violencia contra la mujer; Trastornos de la nutrición del niño; Desnutrición; Niño (fuente: DeCS BIREME). ASSOCIATION BETWEEN VIOLENCE AGAINST WOMEN INFLICTED BY THE PARTNER AND CHRONIC MALNUTRITION IN THEIR CHILDREN UNDER FIVE YEARS OLD IN PERU ABSTRACTObjectives. To assess the association between violence against women inflicted by their partner and the prevalence of chronic malnutrition in their children less than five years old. Materials and methods. A secondary cross-sectional analysis of the 2001 Peru Demographic and Health Survey performed in Peru, with national representativeness. The dependent variable was chronic malnutrition in the youngest child under five years old. The independent variables were emotional violence, physical violence (mild or severe) and sexual violence self-report; the violence was inflicted by the mother's last partner or spouse in the last 12 months. Univariate and multivariate analysis was performed, generalized linear models (log-binomial regression) were used, and the nature of the sample was taken into account. Models for socio-demographic and mother-son health variables were adjusted. Prevalence ratios (PR) and confidence intervals were calculated. Results. Data from 5,154 mothers and children were analyzed. The prevalence of chronic malnutrition was 19.8% (CI 95%: 18.1-21.6). In the multivariate analysis, a higher prevalence of chronic malnutrition was found in the c...

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Relationships between perceived workload, stress and oxidative DNA damage

Abstract: Psychological stress and perceived over-work appear to be related to the pathogenesis of cancer via the formation of 8-OH-dG, particularly in female workers.

Cited by 127 publications

References 23 publications

Depression gets old fast: do stress and depression accelerate cell aging?

Depression gets old fast: do stress and depression accelerate cell aging?

Accelerated telomere shortening in response to life stress

Asociación entre violencia contra la mujer ejercida por la pareja y desnutrición crónica en sus hijos menores de cinco años en Perú

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