Relationships Between Right Ventricular Function, Body Composition, and Prognosis in Advanced Heart Failure

Melenovský, Vojtěch; Kotrč, Martin; Borlaug, Barry A.; Marek, Tomáš; Kovář, J.; Málek, I; Kautzner, Josef

doi:10.1016/j.jacc.2013.06.046

Cited by 140 publications

(119 citation statements)

References 47 publications

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“…Some authors described the positive correlations between adiponectin, severity of HF, and NT-proBNP [7,21], whereas Melenovsky et al found an inverse relationship between plasma BNP and concentrations of leptin in HF patients [26]. We observed no correlation with leptin or adiponectin concentration.…”

Section: Prace Oryginalnecontrasting

confidence: 75%

Wpływ BMI, stężenia leptyny i adiponektyny na rokowanie u pacjentów z niedokrwienną kardiomiopatią rozstrzeniową

Wojciechowska

Jacheć

Romuk

et al. 2017

Endokrynologia Polska

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Introduction:The recent studies demonstrated that obese heart failure patients have better prognosis -"obesity paradox". The aim of the study was to evaluate the relationship between body mass index (BMI), leptin and adiponectin concentrations and prognosis in patients with heart failure due to non ischeamic dilated cardiomyopathy (NIDCM). Material and methods: 128 patients with NIDCM were included and followed-up for three years. Leptin and adiponectin were measured at baseline using commercially available ELISA tests. Clinical data, routine laboratory parameters, NT-proBNP were assessed as risk factors for reaching the study endpoints: urgent heart transplantation (B), death (C), or combined endpoint death or urgent heart transplantation (D). Results: Patient with adverse outcome had lower BMI and higher NT-proBNP concentration. Leptin was significantly elevated in group C and adiponectin was higher in groups B and D than in survived patients. Patients with leptin concentration below median or with adiponectin concentration above median were more often transplanted in three years follow-up (p = 0.029, p = 0.022, respectively). The cumulative probability of death was greater in patients with concentration of leptin above median (p = 0.024). In the multivariable Cox proportional hazards analyses, increasing leptin and lower BMI were predictors of death. Adiponectin was associated with higher risk of heart transplantation. Both an inverse association of BMI and positive association of leptin and adiponectin with combined endpoint were discovered. Further adjustment to established risk factors abolished association between combined endpoint and BMI, and modestly attenuate with adiponectin and leptin concentration. Conclusion: Evaluation of adiponectin and leptin concentrations was more useful than BMI in prediction of unfavourable outcome in patients with NIDCM. (Endokrynol Pol 2017; 68 (1): 26-34)

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Section: Prace Oryginalnecontrasting

confidence: 75%

Wpływ BMI, stężenia leptyny i adiponektyny na rokowanie u pacjentów z niedokrwienną kardiomiopatią rozstrzeniową

Wojciechowska

Jacheć

Romuk

et al. 2017

Endokrynologia Polska

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“…Interestingly, RV systolic dysfunction was a significant predictor of mortality even after adjustment for age and PASP in a Cox regression model (Hazard Ratio=1.4, P=0.02; Figure 5). Further evidence has recently been brought by Melenovsky et al 45 reporting a worse RV function and prognosis in PH-HFpEF associated with atrial fibrillation.…”

Section: Guazzi Pulmonary Hypertension In Diastolic Heart Failure 371mentioning

confidence: 94%

“…6 Studies investigating the pattern of right heart function and geometry in PH-HFpEF are summarized in Table 1. [9][10][11]14,15,21,[40][41][42][43][44][45] In a report by Puwanant et al, 11 RV dysfunction, assessed by RV fractional area and tissue Doppler S prime, was not uncommon in patients with HFpEF although in a milder degree compared with HFrEF. Similar findings were reported by looking at RV global longitudinal early diastolic strain rate and systolic RV global longitudinal systolic strain.…”

Section: Guazzi Pulmonary Hypertension In Diastolic Heart Failure 371mentioning

confidence: 99%

Pulmonary Hypertension in Heart Failure Preserved Ejection Fraction

Guazzi

2014

Circ: Heart Failure

102

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“…62 However, evidence from prospective studies indicates that the decrease in fat mass precedes that of lean mass. [63][64][65] Moreover, individuals with cardiac cachexia have exceedingly high circulating levels of BNP, including a significant fraction of incompletely processed N-terminal pro-BNP.…”

Section: Cardiac Cachexiamentioning

confidence: 99%

A heart–adipose tissue connection in the regulation of energy metabolism

2013

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| Almost 20 years ago, the protein encoded by the ob locus in mice was identified as an adipocytesecreted hormone, now termed leptin, which functions as a peripheral signal to communicate the organism's energy reserve-and thereby protects against starvation due to insufficient caloric resources. Additional peripheral factors have since been identified that coordinate interorgan crosstalk to manage energy resources. The heart is included in this network through its regulated release of natriuretic peptides A and B-cardiac hormones originally identified as important in blood pressure control. Emerging evidence that natriuretic peptide receptors are expressed in adipose tissue, and that circulating levels of these peptides are decreased in animals and humans with obesity, could imply that natriuretic peptides are also involved in the regulation of energy metabolism. The natriuretic peptides stimulate triglyceride lipolysis in adipocytes, a process also regulated by the sympathetic nervous system. In addition, these two pathways promote uncoupling of mitochondrial respiration and thermogenesis in brown adipocytes. This Review focuses on the roles of the natriuretic peptides and the sympathetic nervous system in regulating adipocyte metabolism. The potential for manipulating the natriuretic peptide pathway to increase energy expenditure in obesity and manage the complications of cardiometabolic disease is also discussed.

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Relationships Between Right Ventricular Function, Body Composition, and Prognosis in Advanced Heart Failure

Cited by 140 publications

References 47 publications

Wpływ BMI, stężenia leptyny i adiponektyny na rokowanie u pacjentów z niedokrwienną kardiomiopatią rozstrzeniową

Wpływ BMI, stężenia leptyny i adiponektyny na rokowanie u pacjentów z niedokrwienną kardiomiopatią rozstrzeniową

Pulmonary Hypertension in Heart Failure Preserved Ejection Fraction

A heart–adipose tissue connection in the regulation of energy metabolism

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