Relationships Between the Importation, Transmission, and Nosocomial Infections of Methicillin-Resistant Staphylococcus aureus: An Observational Study of 112 Veterans Affairs Medical Centers

Jones, Makoto; Jin, Ying; Huttner, Benedikt; Evans, Martin; Maw, Matthew; Nielson, Christopher; Rubin, Michael; Greene, Tom; Samore, Matthew H.

doi:10.1093/cid/cit668

Cited by 28 publications

(19 citation statements)

References 32 publications

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“…This could be explained by the fact that many nosocomial infections associated with MRSA are caused by infection of the patient by multiresistant hospital strains from other patients or health care personnel [23,24,25] and are frequently associated with prolonged hospitalization. In addition, the intense exposure to antibiotics to which these patients are subjected also plays an important role in infection due to multiresistant microorganisms during their stay in hospital [26,27,28] as well as recurrence of certain infections [29,30,31].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Methicillin-Resistant Staphylococcus aureus: Effect of Different Criteria for Elimination of Duplicates

Álvarez-Paredes

López-Riquelme²,

Rodrı́guez³

et al. 2013

Chemotherapy

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Background: The purpose of this study is to compare the effect of different systems for eliminating duplicates in order to optimize the calculation of the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) infection. Methods: We compare the Clinical and Laboratory Standards Institute (CLSI) criterion, time criteria and the criterion recommended by the European Antimicrobial Surveillance System (EARSS). Results: Multiple isolates of MRSA are frequently recovered from successive cultures from the same patient (the average isolation rate of MRSA is 2.72), which demonstrates the importance of eliminating duplicates. When CLSI criterion data are compared to those obtained using other criteria, a significant increase in the number of S. aureus isolates was found applying time criteria (up to 36%) or the EARSS criterion (13%). There is also an increase in the methicillin resistance rate (between 3.31 and 3.96%; p < 0.01). Conclusions: We believe that the EARSS method, with the proper quality controls and latest software tools available, is the best for determining the true situation of MRSA.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Methicillin-Resistant Staphylococcus aureus: Effect of Different Criteria for Elimination of Duplicates

Álvarez-Paredes

López-Riquelme²,

Rodrı́guez³

et al. 2013

Chemotherapy

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“…Although not within the scope of the present analysis, cross-bacterial colonization can increase with prolonged LoS and is mainly caused by MRSA. Clinicians should consider colonization in assessments of discharging patients from the hospital, particularly if the clinical conditions are improved and stable [42,43].…”

Section: Discussionmentioning

confidence: 99%

Economic evaluation of the treatment of Acute Bacterial Skin and Skin Structure Infections (ABSSSIs) from the national payer perspective: introduction of a new treatment to the patient journey. A simulation of three European countries

Marcellusi

Viti

Sciattella

et al. 2019

Expert Review of Pharmacoeconomics & Outcomes Research

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Background: The aim of this study was to develop a spending predictor model to evaluate the direct costs associated with the management of ABSSSIs from the National healthcare provider's perspective of Italy, Romania and Spain. Methodology: A decision-analytic model was developed to evaluate the diagnostic and clinical pathways of hospitalized ABSSSI patients based on scientific guidelines and realworld data. A Standard of Care (SoC) scenario was compared with a dalbavancin scenario in which the patients could be discharged early. The epidemiological and cost parameters were extrapolated from national administrative databases (i.e., hospital information system). A probabilistic sensitivity analysis (PSA) and one-way sensitivity analysis (OWA) were performed. Results: Overall, the model estimated an average annual number of patients with ABSSSIs of approximately 50,000 in Italy, Spain and Romania. On average, the introduction of dalbavancin reduced the length of stay by 3.3 days per ABSSSI patient. From an economic perspective, dalbavancin did not incur any additional cost from the NHS perspective, and the results were consistent among the countries. The PSA and OWA demonstrated the robustness of these results. Conclusion: This model represents a useful tool for policymakers by providing information regarding the economic and organisational consequences of an early discharge approach in ABSSSI management.

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“…[9][10][11][12][13][14] PJIs and osteomyelitis (OM) are typically caused by Staphylococcus aureus (S. aureus), a Gram-positive microorganism, 14,15 which is a major pathogen that causes community-associated nosocomial infections. 16,17 The biofilm produced by S. aureus, a self-produced matrix of hydrated extracellular polymeric substances composed of polysaccharides, proteins, lipids, and extracellular nucleic acids, can contaminate internal medical devices and orthopedic implants and surgeries, resulting in serious health care concerns because of their resistance to antibiotics. 18 Additionally, methicillinresistant S. aureus (MRSA) has gradually increased in proportion among the clinical isolates of S. aureus, 19 showing .50% prevalence among hospital pathogens in several Asian countries 20 and increases in the human population.…”

Section: Introductionmentioning

confidence: 99%

Curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections

Peng¹,

Chiang²,

Huang³

et al. 2019

IJN

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BackgroundPeriprosthetic joint infections (PJIs) have a high incidence of recurrence after total joint replacement and are difficult to treat by debridement or antibiotic treatment. Curcumin is a natural product with anti-inflammatory and anti-bacterial properties. The low bioactivity of curcumin in water restricts its clinical application. Curcumin nanoparticles (CURN) were developed to overcome this limitation.MethodsIn this study, the therapeutic effects of CURN and their anti-inflammatory functions were investigated in a Staphylococcus aureus biofilm-induced PJIs model.ResultsCURN first attenuated the biofilm-induced expansion of myeloid-derived suppressor cells (MDSCs) and then regulated M1- and M2-phenotypic MDSC expression. Down-regulation of cytokines and reactive oxygen species was considered as the mechanism of CURN in reversing the suppression of T cell proliferation. The recovery of bone permeative destruction demonstrated that CURN enhanced therapeutic potency of vancomycin in vivo.ConclusionThis is the first study to demonstrate that CURN may be useful for treating PJIs.

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Relationships Between the Importation, Transmission, and Nosocomial Infections of Methicillin-Resistant Staphylococcus aureus: An Observational Study of 112 Veterans Affairs Medical Centers

Cited by 28 publications

References 32 publications

Prevalence of Methicillin-Resistant <b><i>Staphylococcus aureus</i></b>: Effect of Different Criteria for Elimination of Duplicates

Prevalence of Methicillin-Resistant <b><i>Staphylococcus aureus</i></b>: Effect of Different Criteria for Elimination of Duplicates

Economic evaluation of the treatment of Acute Bacterial Skin and Skin Structure Infections (ABSSSIs) from the national payer perspective: introduction of a new treatment to the patient journey. A simulation of three European countries

Curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections

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