Relationships between the pharmacological treatment method and negative symptoms, depression, social functioning and quality of life in schizophrenia patients during 11–15 years after a first psychiatric hospitalisation

Abstract

hospitalised for the first time 11 to 15 years ago. Depres sive symptoms, social functioning, and quality of life were also scrutinised. Methods. 56 patients were assessed one month after the hospitalisation (Time 1), and then as follows: 1 year later, 4-6, 7-11 and 11-15 years after Time 1. The following measures were used: Marder's Negative Symptoms Fac tor Score (NSFS), Calgary Depression Scale for Schizo phrenia (CDSS), Social Functioning (SFS) and WHOQoL -Bref scales. Results. Most patients received antipsychotic medica tions throughout the whole observation period (85.7-94.6%). Out of them, 69.6-77.6% were treated with an tipsychotics only and 22.9-32.4% with antipsychotics + antidepressants. There were no significant relationships between the mode of treatment and the frequency of negative symptoms or significant differences between the compared groups regarding the mean scores of the CDSS, SFS, and WHOQoL at any time point of the observation. Conclusions. The way of treatment in terms of mono therapy (antipsychotics only) vs polytherapy (+ anti depressants) did not differentiate the frequency of Original article / Artykuł oryginalnyRelationships between the pharmacological treatment method and negative symptoms, depression, social functioning and quality of life in schizophrenia patients during 11-15 years after a first psychiatric hospitalisation Zależność pomiędzy sposobem leczenia farmakologicznego a objawami negatywnymi, depresją, funkcjonowaniem społecznym i jakością życia chorych na schizofrenię w okresie 11-15 lat po pierwszej hospitalizacji psychiatrycznej