Relationships between the Structure and the Bactericidal Properties of Phenols.

Suter, C. M.

doi:10.1021/cr60090a004

Cited by 65 publications

(30 citation statements)

References 46 publications

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“…One of the two effective commercially-available phenolics identified (40) contains a substituted phenol not found in the other products tested (p-tertiary amyl phenol). Such para-substituents of short alkyl chains are known to have increased bactericidal properties (Suter, 1941) but similar studies on their virucidal efficacy have not been conducted. The other (48) contained a relatively high concentration of an anionic surfactant, which was completely ineffective against HRV when tested alone (9) at the same concentration.…”

Section: Discussionmentioning

confidence: 99%

Chemical disinfection of human rotaviruses: efficacy of commercially-available products in suspension tests

Springthorpe

Grenier

Lloyd-Evans

et al. 1986

J. Hyg.

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SUMMARYSuspension tests were conducted on 69 commercial and 7 non-commercial disinfectant formulations to determine which classes of chemicals were most active against human rotavirus (HRV). Virus samples, in the presence of varying levels of organic matter, were exposed to the disinfectants for 1 min. The levels of remaining infectious virus were determined by plaque assay. Products were rated by their ability to reduce the levels of infectious virus by more than 3 log1o in the presence or absence of tryptose phosphate broth (peptides and inorganic salts) or fecal matter.Of the commercially-available products tested, only 25 % were rated as highly and 7 % as moderately effective. The remaining 68 % were either effective only in the absence of any additional organic matter (48 %) or were completely ineffective (20 %). The majority (64 %) of the moderately and highly effective products were further examined for their ability to inactivate > 6 log1o of infectious HRV in the presence of fecal matter or tryptose phosphate broth. With one exception, all these products were still effective. Products potentially suitable as topical antiseptics, hard surface disinfectants and instrument soaks were identified. The results emphasize the care that should be exercised in the selection of disinfectants for the control and prevention of rotaviral infections.

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Section: Discussionmentioning

confidence: 99%

Chemical disinfection of human rotaviruses: efficacy of commercially-available products in suspension tests

Springthorpe

Grenier

Lloyd-Evans

et al. 1986

J. Hyg.

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“…Prindle (1983) reported several generalisations that can be made about the structural activity relation of simple and complexed phenols. The position of the alkyl chain may or may not influence activity; separation of the alkyl group from the phenol nucleus by an oxygen (methoxy) decreases activity (Veldhuizen et al, 2006;Ja Kim et al, 2006;Prindle, 1983;Suter, 1941;Klarmann and Shternov, 1936).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial activity of plant phenols from Chlorophora excelsa and Virgilia oroboides

Padayachee¹,

Odhav²

2013

Afr. J. Biotechnol.

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The anti-bacterial and anti-fungal activity of four aqueous plant extracts (1 x 10 4 µg/ml) of 2,3'4,5'-tetra hydroxy-4'-geranylstilbene (chlorophorin) and 3',4, 5' -trihydroxy -4' -geranylstilbene (Iroko) from the tree Chlorophora excelsa and (6aR,11aR)-3-hydroxy-8,9-methylenedioxypterocarpan (Maackiain) and 7-hydroxy-4'-methoxyisoflavone (formononetin) from Virgilia oroboides were evaluated by the seeded agar overlay well diffusion method. The test organisms and bioautography used included: Bacillus coagulans, Streptococcus pneumoniae, Klebsiella pneumoniae, Escherichia coli, Mycobacteria tuberculosis, Aspergillus flavus and Fusarium verticilloides. Vancomycin, the drug of choice for these organisms was used as the control at 30 µg/ml. The extracts showed that chlorophorin at 1.95 µg/ml and Iroko at 3.125 and 6.25 µg/ml respectively were active in inhibiting the growth of S. pneumoniae and B. coagulans and not active against K. pneumoniae and E. coli. Maackiain; formononetin and formononetin acetate showed little activity against S. pneumonia, B. coagulans, K. pneumoniae and E. coli. None of the extracts showed activity against M. tuberculosis. Maackiain, formononetin, chlorophorin and Iroko inhibited F. vertiicilloides, maackiain being the most active compound. Formononetin, chlorophorin and Iroko inhibited A. flavus. A. flavus was most sensitive to chlorophorin and Iroko. The bioautography method confirmed these results and was attributed to the phenolic nature of the compounds.

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“…The phenoxyl radical is less reactive because it is stabilized by the resonance effect. The antimicrobial activity of phenolic compounds is highly dependent upon the chemical structure of the molecules [9]. The bactericidal actions of substituted phenols and the normal alkyl derivatives of p-chlorophenols were examined against Gram-negative and Gram-positive bacteria [10,11].…”

Section: Introductionmentioning

confidence: 99%

Investigation of Isotopic Abundance Ratio of Biofield Treated Phenol Derivatives Using Gas Chromatography-Mass Spectrometry

MK¹,

Branton²

2015

J Chromatograph Separat Techniq

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Relationships between the Structure and the Bactericidal Properties of Phenols.

Cited by 65 publications

References 46 publications

Chemical disinfection of human rotaviruses: efficacy of commercially-available products in suspension tests

Chemical disinfection of human rotaviruses: efficacy of commercially-available products in suspension tests

Antimicrobial activity of plant phenols from Chlorophora excelsa and Virgilia oroboides

Investigation of Isotopic Abundance Ratio of Biofield Treated Phenol Derivatives Using Gas Chromatography-Mass Spectrometry

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