Relationships between tissue composition and viscoelastic properties in human trabecular bone

Ojanen, Xiaowei; Isaksson, Hanna; Töyräs, Juha; Turunen, Mikael J.; Malo, Markus; Halvari, A; Jurvelin, Jukka S.

doi:10.1016/j.jbiomech.2014.11.034

Cited by 29 publications

(23 citation statements)

References 48 publications

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“…Collecting 21 proximal femurs from male cadavers (17 to 82 yo), Ojanen et al [40] conducted nanoindentation tests on hydrated trabecular bone from the femoral neck without embedding the bone (ground and polished flat end of a core). For 10 unique trabeculae (5 tests per trabeculae), tissue was indented in force control to 30 mN, and in addition to H and E using the Oliver-Pharr (OP) method (Fig.…”

Section: Independence Of Tissue-level Mechanical Properties From Donomentioning

confidence: 99%

“…1) [41], they determined viscoelastic parameters during the dwell (60 s) using a Burgers rheological model of creep. Neither the elastic properties nor creep viscosity were associated with age [40]. Incidentally, in a similar nanoindentation study involving creep behavior of wet cortical bone (20 indents of interstitial and 20 indents of osteonal tissue per donor), Wu et al [16] reported a significant difference in the exponential decay of creep between males (51 – 87 yo, n=10) and females (58 – 89, n=10) with no relationship to age.…”

Section: Independence Of Tissue-level Mechanical Properties From Donomentioning

confidence: 99%

“…Using IMI with the OsteoProbe instrument (the current technique being actively investigated for clinical use), Malgo et al [38] conducted a case-control study involving a cohort of 90 patients ([40 – 86] yo) having either osteopenia (T-score <−1.0) or osteoporosis (T-score < −2.5). BMSi was lower in patients with a fragility fracture (n=63) compared with non-fracture subjects (n=27), independent of BMD.…”

Section: Osteoporosis-related Differences In Indentation-derived Mechmentioning

confidence: 99%

“…Another reason to prefer larger indents is that relative errors in the calculated projected contact area due to effects like surface roughness, misidentification of the location of the surface during the approach of the indenter to the surface, or uncertainties in the tip area function (the precise geometry of the indenter tip) are reduced. Accurate measurements of the projected contact area are crucial to almost all nanoindentation property measurements [40]. …”

Section: Challenges and Recommendations In The Application Of Nanoindmentioning

confidence: 99%

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Tissue-Level Mechanical Properties of Bone Contributing to Fracture Risk

Nyman

Granke

Singleton

et al. 2016

Curr Osteoporos Rep

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Tissue-level mechanical properties characterize mechanical behavior independently of microscopic porosity. Specifically, quasi-static nanoindentation provides measurements of modulus (stiffness) and hardness (resistance to yielding) of tissue at the length scale of the lamella, while dynamic nanoindentation assesses time-dependent behavior in the form of storage modulus (stiffness), loss modulus (dampening), and loss factor (ratio of the two). While these properties are useful in establishing how a gene, signaling pathway, or disease of interest affects bone tissue, they generally do not vary with aging after skeletal maturation or with osteoporosis. Heterogeneity in tissue-level mechanical properties or in compositional properties may contribute to fracture risk, but a consensus on whether the contribution is negative or positive has not emerged. In vivo indentation of bone tissue is now possible, and the mechanical resistance to microindentation has the potential for improving fracture risk assessment, though determinants are currently unknown.

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Section: Independence Of Tissue-level Mechanical Properties From Donomentioning

confidence: 99%

Section: Independence Of Tissue-level Mechanical Properties From Donomentioning

confidence: 99%

Section: Osteoporosis-related Differences In Indentation-derived Mechmentioning

confidence: 99%

Section: Challenges and Recommendations In The Application Of Nanoindmentioning

confidence: 99%

See 2 more Smart Citations

Tissue-Level Mechanical Properties of Bone Contributing to Fracture Risk

Nyman

Granke

Singleton

et al. 2016

Curr Osteoporos Rep

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“…The mineral phase reduces the motion of collagen chains and this, in turn, reduces the viscosity of the bone (Wang and Feng, 2005;Yamashita et al, 2001). When the HA crystals become larger, bone viscoelastic property seems to increase (Ojanen et al, 2015) while viscosity of the bone matrix seems to decrease with increasing number of mature collagen crosslinks (Isaksson et al, 2010a). As the bone is exposed daily to dynamic loading, its viscoelastic properties and their changes with age or disease, may critically contribute to e.g.…”

Section: Introductionmentioning

confidence: 99%

Tissue viscoelasticity is related to tissue composition but may not fully predict the apparent-level viscoelasticity in human trabecular bone – An experimental and finite element study

Ojanen

Tanska

Malo

et al. 2017

Journal of Biomechanics

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Trabecular bone is viscoelastic under dynamic loading. However, it is unclear how tissue viscoelasticity controls viscoelasticity at the apparent-level. In this study, viscoelasticity of cylindrical human trabecular bone samples (n=11, male, age 18-78 years) from 11 proximal femurs were characterized using dynamic and stress-relaxation testing at the apparent-level and with creep nanoindentation at the tissue-level. In addition, bone tissue elasticity was determined using scanning acoustic microscope (SAM). Tissue composition and collagen crosslinks were assessed using Raman micro-spectroscopy and high performance liquid chromatography (HPLC), respectively. Values of material parameters were obtained from finite element (FE) models by optimizing tissue-level creep and apparent-level stress-relaxation to experimental nanoindentation and unconfined compression testing values, respectively, utilizing the second order Prony series to depict viscoelasticity. FE simulations showed that tissue-level equilibrium elastic modulus (E) increased with increasing crystallinity (r=0.730, p=.011) while at the apparent-level it increased with increasing hydroxylysyl pyridinoline content (r=0.718, p=.019). In addition, the normalized shear modulus g (r=-0.780, p=.005) decreased with increasing collagen ratio (amide III/CH) at the tissue-level, but increased (r=0.696, p=.025) with increasing collagen ratio at the apparent-level. No significant relations were found between the measured or simulated viscoelastic parameters at the tissue- and apparent-levels nor were the parameters related to tissue elasticity determined with SAM. However, only E, g and relaxation time τ from simulated viscoelastic values were statistically different between tissue- and apparent-levels (p<.01). These findings indicate that bone tissue viscoelasticity is affected by tissue composition but may not fully predict the macroscale viscoelasticity in human trabecular bone.

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Development of a Multifunctional Platform Based on Strong, Intrinsically Photoluminescent and Antimicrobial Silica‐Poly(citrates)‐Based Hybrid Biodegradable Elastomers for Bone Regeneration

Juan

et al. 2015

Adv Funct Materials

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Biodegradable biomaterials with intrinsically multifunctional properties such as high strength, photoluminescent ability (bioimaging monitoring), and antimicrobial activity (anti‐infection), as well as high osteoblastic differentiation ability, play a critical role in successful bone tissue regeneration. However, fabricating a biomaterial containing all these functions is still a challenge. Here, urethane cross‐linked intrinsically multifunctional silica‐poly(citrate) (CMSPC)‐based hybrid elastomers are developed by first one‐step polymerization and further chemical crosslinked using isocyanate. CMSPC hybrid elastomers demonstrate a high modulus of 976 ± 15 MPa, which is superior compared with most conventional poly(citrate)‐based elastomers. Hybrid elastomers show strong and stable intrinsic photoluminescent ability (emission 400–600 nm) due to the incorporation of silica phase. All elastomers exhibit high inherent antibacterial properties against Staphylococcus aureus. In addition, CMSPC hybrid elastomers significantly enhance the proliferation and metabolic activity of osteoblasts (MC3T3‐E1). CMSPC hybrid elastomers significantly promote the osteogenic differentiation of MC3T3‐E1 by improving alkaline phosphatase activity and calcium biomineralization deposits, as well as expressions of osteoblastic genes. These hybrid elastomers also show a minimal inflammatory response indicated by subcutaneous transplantation in vivo. These optimized structure and multifunctional properties make this hybrid elastomer highly promising for bone tissue regeneration and antiinfection and bioimaging applications.

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Relationships between tissue composition and viscoelastic properties in human trabecular bone

Cited by 29 publications

References 48 publications

Tissue-Level Mechanical Properties of Bone Contributing to Fracture Risk

Tissue-Level Mechanical Properties of Bone Contributing to Fracture Risk

Tissue viscoelasticity is related to tissue composition but may not fully predict the apparent-level viscoelasticity in human trabecular bone – An experimental and finite element study

Development of a Multifunctional Platform Based on Strong, Intrinsically Photoluminescent and Antimicrobial Silica‐Poly(citrates)‐Based Hybrid Biodegradable Elastomers for Bone Regeneration

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