Relationships between Uncoupling Protein Genes UCP1, UCP2 and UCP3 and Irisin Levels in Residents of the Coldest Region of Siberia

Nikanorova, A.A.; Barashkov, Nikolay A.; Pshennikova, Vera G.; Gotovtsev, Nyurgun N.; Romanov, Georgii P.; Solovyev, Alexey V.; Kuzmina, S.S.; Sazonov, Nikolay N.; Fedorova, Sardana A.

doi:10.3390/genes13091612

Cited by 6 publications

(1 citation statement)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A large study of Siberian populations identified candidate genes for adaptation to the cold, associated with energy and metabolic regulation, as well as contraction of vascular smooth muscle [9]. Besides, leptin and irisin, which play an important role in the processes of adaptation to the cold, become the focus of several other studies of the Yakutian cohort [13][14][15]. However, genetic studies for Siberian populations are often limited to mitochondrial DNA, Y chromosome or single-nucleotide polymorphisms [8,9,16,17], while epigenome-wide studies have not been performed.…”

Section: Introductionmentioning

confidence: 99%

Epigenetic features of far northern Yakutian population

Kalyakulina

Yusipov

Kondakova³

et al. 2023

Preprint

View full text Add to dashboard Cite

Yakuts are one of the indigenous populations of the subarctic and arctic territories of Siberia characterized by a continental subarctic climate with severe winters, with the regular January average temperature in the regional capital city of Yakutsk dipping below -40°C. The epigenetic mechanisms of adaptation to such ecologies and environments and, in particular, epigenetic age acceleration in the local population have not been studied before. This work reports the first epigenetic study of the Yakutian population using whole blood DNA methylation data, supplemented with the comparison to the residents of Central Russia. Gene set enrichment analysis revealed, among others, geographic region-specific differentially methylated regions associated with adaptation to climatic conditions (water consumption, digestive system regulation), aging processes (actin filament activity, cell fate), and both of them (channel activity, regulation of steroid and corticosteroid hormone secretion). Further, it is demonstrated that the epigenetic age acceleration of the Yakutian representatives is significantly higher than that of Central Russia counterparts. For both geographic regions, we showed that epigenetically males age faster than females, whereas no significant sex differences were found between the regions.

show abstract

Section: Introductionmentioning

confidence: 99%

Epigenetic features of far northern Yakutian population

Kalyakulina

Yusipov

Kondakova³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Exploring the Frontiers of Cell Temperature Measurement and Thermogenesis

Zhu,

Xu,

Zhang

et al. 2024

Advanced Science

View full text Add to dashboard Cite

The precise measurement of cell temperature and an in‐depth understanding of thermogenic processes are critical in unraveling the complexities of cellular metabolism and its implications for health and disease. This review focuses on the mechanisms of local temperature generation within cells and the array of methods developed for accurate temperature assessment. The contact and noncontact techniques are introduced, including infrared thermography, fluorescence thermometry, and other innovative approaches to localized temperature measurement. The role of thermogenesis in cellular metabolism, highlighting the integral function of temperature regulation in cellular processes, environmental adaptation, and the implications of thermogenic dysregulation in diseases such as metabolic disorders and cancer are further discussed. The challenges and limitations in this field are critically analyzed while technological advancements and future directions are proposed to overcome these barriers. This review aims to provide a consolidated resource for current methodologies, stimulate discussion on the limitations and challenges, and inspire future innovations in the study of cellular thermodynamics.

show abstract

Differential mitochondrial adaptation and FNDC5 production in brown and white adipose tissue in response to cold and obesity

Neira,

Hernández‐Pardos,

Becerril

et al. 2024

Obesity

View full text Add to dashboard Cite

ObjectiveFibronectin type III domain‐containing protein 5 (FNDC5) modulates adipocyte metabolism by increasing white and brown adipose tissue (WAT and BAT) browning and activity, respectively. We investigated whether FNDC5 can regulate visceral WAT and BAT adaptive thermogenesis by improving mitochondrial homeostasis in response to cold and obesity.MethodsAdipose tissue expression of FNDC5 and factors involved in mitochondrial homeostasis were determined in patients with normal weight and obesity (n = 159) and in rats with diet‐induced obesity after 1 week of cold exposure (n = 61). The effect of different FNDC5 concentrations on mitochondrial biogenesis, dynamics, and mitophagy was evaluated in vitro in human adipocytes.ResultsIn human visceral adipocytes, FNDC5/irisin triggered mitochondrial biogenesis (TFAM) and fusion (MFN1, MFN2, and OPA1) while inhibiting peripheral fission (DNM1L and FIS1) and mitophagy (PINK1 and PRKN). Circulating and visceral WAT expression of FNDC5 was decreased in patients and experimental animals with obesity, whereas its receptor, integrin αV, was upregulated. Obesity increased mitochondrial fusion while decreasing mitophagy in visceral WAT from patients and rats. By contrast, in rat BAT, an upregulation of Fndc5 and genes involved in mitochondrial biogenesis and fission was observed. Cold exposure promoted mitochondrial biogenesis and healthy peripheral fission while repressing Fndc5 expression and mitophagy in BAT from rats.ConclusionsDepot differences in FNDC5 production and mitochondrial adaptations in response to obesity and cold might indicate a self‐regulatory mechanism to control thermogenesis in response to energy needs.image

show abstract

Relationships between Uncoupling Protein Genes UCP1, UCP2 and UCP3 and Irisin Levels in Residents of the Coldest Region of Siberia

Cited by 6 publications

References 81 publications

Epigenetic features of far northern Yakutian population

Epigenetic features of far northern Yakutian population

Exploring the Frontiers of Cell Temperature Measurement and Thermogenesis

Differential mitochondrial adaptation and FNDC5 production in brown and white adipose tissue in response to cold and obesity

Contact Info

Product

Resources

About