Relationships between visceral/subcutaneous adipose tissue FABP4 expression and coronary atherosclerosis in patients with metabolic syndrome

Görmez, Selçuk; Erdim, Refik; Akan, Gökçe; Çaynak, Barış; Duran, Cihan; Günay, Demet; Sözer, Volkan; Atalar, Fatmahan

doi:10.1016/j.carpath.2019.107192

Cited by 17 publications

(17 citation statements)

References 32 publications

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“…The study by Rosito et al showed that while EAT was associated with coronary artery calcification, paracardial fat was associated with abdominal aorta calcification, which points to the different roles of paracrine modulators between EAT and paracardial fat on vascular calcification [26]. Several recent studies have revealed that FABP 4 expression in EAT was strongly associated with the extent of atherosclerosis in coronary artery disease patients with metabolic syndrome [27], and annexin-A2/fetuin-A signaling in EAT was linked to the pathophysiology of coronary atherosclerotic calcification in elderly patients with coronary artery disease [28]. However, since no association between EAT and coronary atherosclerosis was not observed in patients with type 1 diabetes [29], additional pathophysiologic studies are needed about whether the role of EAT on coronary atherosclerosis may differ depending on the type of DM.…”

Section: Association Of Pat With Cvdmentioning

confidence: 99%

Association of pericardial adipose tissue with left ventricular structure and function: a region‐specific effect?

Kim

Lee

et al. 2021

Cardiovasc Diabetol

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Background The independent role of pericardial adipose tissue (PAT) as an ectopic fat associated with cardiovascular disease (CVD) remains controversial. This study aimed to determine whether PAT is associated with left ventricular (LV) structure and function independent of other markers of general obesity. Methods We studied 2471 participants (50.9 % women) without known CVD from the Korean Genome Epidemiology Study, who underwent 2D-echocardiography with tissue Doppler imaging (TDI) and computed tomography measurement for PAT. Results Study participants with more PAT were more likely to be men and had higher cardiometabolic indices, including blood pressure, glucose, and cholesterol levels (all P < 0.001). Greater pericardial fat levels across quartiles of PAT were associated with increased LV mass index and left atrial volume index (all P < 0.001) and decreased systolic (P = 0.015) and early diastolic (P < 0.001) TDI velocities, except for LV ejection fraction. These associations remained after a multivariable-adjusted model for traditional CV risk factors and persisted even after additional adjustment for general adiposity measures, such as waist circumference and body mass index. PAT was also the only obesity index independently associated with systolic TDI velocity (P < 0.001). Conclusions PAT was associated with subclinical LV structural and functional deterioration, and these associations were independent of and stronger than with general and abdominal obesity measures.

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Section: Association Of Pat With Cvdmentioning

confidence: 99%

Association of pericardial adipose tissue with left ventricular structure and function: a region‐specific effect?

Kim

Lee

et al. 2021

Cardiovasc Diabetol

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“…However, the accumulation of visceral fat is not the only contributing factor in the development of a pro-inflammatory state. The accumulation of cardiac fat is also associated with higher levels of pro-inflammatory cytokines such as IL-6, IL-1, TNF-α, and the expression of adipokine fatty acidbinding protein 4 (FABP4) that are associated with the development of MetS and the extent of coronary artery disease [27,28]. Hence, overall fat measurement should not be underestimated.…”

Section: Combining Adiposity and Muscle Strength Measurements Increases The Prediction Of Metabolic Alterationsmentioning

confidence: 99%

The prediction of Metabolic Syndrome alterations is improved by combining waist circumference and handgrip strength measurements compared to either alone

López‐López

Cohen

Ney-Salazar

et al. 2021

Cardiovasc Diabetol

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Background Adiposity is a major component of the metabolic syndrome (MetS), low muscle strength has also been identified as a risk factor for MetS and for cardiovascular disease. We describe the prevalence of MetS and evaluate the relationship between muscle strength, anthropometric measures of adiposity, and associations with the cluster of the components of MetS, in a middle-income country. Methods MetS was defined by the International Diabetes Federation criteria. To assess the association between anthropometric variables (waist circumference (WC), waist-to-hip ratio (W/H), body mass index (BMI)), strength (handgrip/kg bodyweight (HGS/BW)) and the cluster of MetS, we created a MetS score. For each alteration (high triglycerides, low HDLc, dysglycemia, or high blood pressure) one point was conferred. To evaluate the association an index of fat:muscle and MetS score, participants were divided into 9 groups based on combinations of sex-specific tertiles of WC and HGS/BW. Results The overall prevalence of MetS in the 5,026 participants (64% women; mean age 51.2 years) was 42%. Lower HGS/BW, and higher WC, BMI, and W/H were associated with a higher MetS score. Amongst the 9 HGS/BW:WC groups, participants in the lowest tertile of HGS/BW and the highest tertile of WC had a higher MetS score (OR = 4.69 in women and OR = 8.25 in men;p < 0.01) compared to those in the highest tertile of HGS/BW and in the lowest tertile of WC. Conclusion WC was the principal risk factor for a high MetS score and an inverse association between HGS/BW and MetS score was found. Combining these anthropometric measures improved the prediction of metabolic alterations over either alone.

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“…Although we did not assess PPARγ activity directly, these data indicate that SCO treatment is promoting adipogenesis by enhancing lipid storage genes, including the PPARγ target genes involved in adipogenesis and lipid accumulation. It is important to note that elevated FABP4 has recently been associated with negative outcomes of metabolic health such as obesity and heart disease (28,41). Although the majority of these findings are correlative, they could suggest FABP4 as a negative regulator of metabolic health.…”

Section: Discussionmentioning

confidence: 99%

Artemisia scoparia promotes adipogenesis in the absence of adipogenic effectors

Harvey

Stephens

2021

Obesity

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Relationships between visceral/subcutaneous adipose tissue FABP4 expression and coronary atherosclerosis in patients with metabolic syndrome

Cited by 17 publications

References 32 publications

Association of pericardial adipose tissue with left ventricular structure and function: a region‐specific effect?

Association of pericardial adipose tissue with left ventricular structure and function: a region‐specific effect?

The prediction of Metabolic Syndrome alterations is improved by combining waist circumference and handgrip strength measurements compared to either alone

Artemisia scoparia promotes adipogenesis in the absence of adipogenic effectors

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