Relationships of Age at Onset With Clinical Features and Cognitive Functions in a Sample of Schizophrenia Patients

Bellino, Silvio; Rocca, Paola; Patria, Luca; Marchiaro, Livio; Rasetti, Roberta; Lorenzo, R. Di; Paradiso, Erika; Bogetto, Filippo

doi:10.4088/jcp.v65n0705

Cited by 49 publications

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“…This impairment could also be explained by the neurodevelopment theory, as subjects with an early onset of illness do not acquire the sufficient abilities in order to successfully develop psychosocially 15 . Hoff 16 found that people with an early age at onset have a greater disability in language abilities as well as more negative symptomatology, also in agreement with Bellino 17 .…”

Section: Discussionmentioning

confidence: 54%

Influence of age at onset on social functioning in outpatients with schizophrenia

et al. 2006

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SPAINABSTRACT -Background and Objectives: There are different factors that have been found to predict disability in schizophrenia. The aim of our study is to evaluate the influence of age at onset on social functioning in schizophrenia in a large sample of schizophrenic outpatients controlling for gender.Methods: Two hundred and thirty-one subjects with schizophrenia (DSM-IV criteria) were randomly selected from a register that included all patients under treatment in five mental health care centers (MHCC) in Spain. Patients were evaluated with a sociodemographic and clinical questionnaire, and the Spanish version of the Living Skills Profile (LSP). Pearson's analyses were performed between age at onset and LSP, and an ANOVA analysis to compare three groups of age at onset (early, middle and late). Gender was introduced as a covariable.Results: Mean age at onset of the total sample was 23 (sd 7.35), with women having a later age at onset than men (women 24.6 (sd 9.1) ; men 22.2 (sd 5.9) (p<0.05)). The relation between age at onset and social functioning was only significant in the not interpersonal social behavior subscale (p<0.01). Early age at onset was positively related to social contact-communication (p<0.05), not interpersonal social behavior (p<0.05) and total LSP score (p<0.05). When including gender as a covariable, a significant relationship between age at onset and social functioning was found in most of the LSP subscales.Conclusions: Early onset of illness negatively influences psychosocial functioning, especially in the areas of communication, not interpersonal social behaviour and self-care. Female gender positively influences most aspects of social functioning.

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Section: Discussionmentioning

confidence: 54%

Influence of age at onset on social functioning in outpatients with schizophrenia

et al. 2006

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“…We can speculate that these differences may be secondary to the different temporal subdivision within the patient groups compared with that in the present study (i.e., 10 years). Other studies found an effect of the duration of illness in determining the number of perseverative responses (Bellino et al, 2004) and the "difficulty to maintain set", another WCST performance measure (Banno et al, 2012). A meta-analysis (Johnson-Selfridge and Zalewski, 2001) of executive functioning in patients with schizophrenia did not uncover any significant effect for DoI on behavioral performance.…”

Section: Clinical Characteristics and Behavioral Performancementioning

confidence: 96%

Medial frontal gyrus alterations in schizophrenia: Relationship with duration of illness and executive dysfunction

Frascarelli

Tognin

Mirigliani

et al. 2015

Psychiatry Research: Neuroimaging

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“…However, their cohort of COS patients had more premorbid developmental abnormalities, more cytogenetic abnormalities, and a greater burden of family history of paranoid and schizotypal personality disorders than later onset cases, pointing to perhaps a greater developmental neurobiologic vulnerability. Their finding that an earlier age of onset of schizophrenia is associated with more severe psychopathology and neurocognitive deficits has been supported by others [26,27]. It has been hypothesized that the typical age of onset of schizophrenia in later adolescence to early adulthood is a manifestation of neurotransmitter ontogeny interacting with neurobiological vulnerability [25].…”

Section: Introductionmentioning

confidence: 94%

Tourette syndrome and comorbid early-onset schizophrenia

Kerbeshian¹,

Peng²,

Burd³

2009

Journal of Psychosomatic Research

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Relationships of Age at Onset With Clinical Features and Cognitive Functions in a Sample of Schizophrenia Patients

Cited by 49 publications

References 0 publications

Influence of age at onset on social functioning in outpatients with schizophrenia

Influence of age at onset on social functioning in outpatients with schizophrenia

Medial frontal gyrus alterations in schizophrenia: Relationship with duration of illness and executive dysfunction

Tourette syndrome and comorbid early-onset schizophrenia

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