Tourette syndrome and comorbid early-onset schizophrenia

Kerbeshian, Jacob; Peng, Chun-Zi; Burd, Larry

doi:10.1016/j.jpsychores.2009.08.002

Cited by 32 publications

(15 citation statements)

References 46 publications

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“…Furthermore, childhood-onset schizophrenia is associated with more comorbidities, especially ADHD and OCD, than schizophrenia with an adolescent-or adultonset. 60 This fact reinforces the idea that TS and the as separation anxiety and some personality disorders.…”

Section: Other Comorbiditiessupporting

confidence: 71%

Tourette's syndrome and associated disorders: a systematic review

Ferreira

Pio-Abreu

Januário

2014

Trends Psychiatry Psychother.

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Objective: To compile data on Tourette's syndrome (TS), tics and associated disorders. Methods: A systematic review of the literature was conducted using the 5S levels of organization of healthcare research evidence (systems, summaries, synopses, syntheses, studies), based on the model described by Haynes. The search keywords were Tourette, tics and comorbidity, which were cross-referenced. Studies provided by publishers and articles being processed on July 31, 2013, were also included. Results: Of all studies retrieved during the search, 64 were selected because they analyzed the epidemiology, clinical features and etiopathogenesis of TS and its comorbidities. TS is classified as a hyperkinetic movement disorder, and at least 90% of the patients have neuropsychiatric comorbidities, of which attention deficit hyperactivity and obsessive-compulsive disorders are the most common. The syndrome is clinically heterogeneous and has been associated with a dysfunction of cortico-striatal-thalamic-cortical circuits involving various neurotransmitters. Although its genetic etiology has been widely studied, other factors may be important to understand this syndrome and its associated disorders. Conclusions: TS is a neurodevelopmental disorder that results from the impact of stress factors on a vulnerable biological substrate during the critical periods of neurodevelopment. The study of TS and its comorbidities may contribute, at different levels, to the understanding of several neuropsychiatric disorders of clinical and therapeutic relevance. Keywords: Attention deficit disorder with hyperactivity, comorbidity, obsessive-compulsive disorder, tics, Tourette's syndrome. ResumoObjetivo: Compilar o conhecimento existente sobre a síndrome de Tourette (ST), tiques e patologias associadas. Metodologia: Foi realizada uma revisão sistemática da literatura usando os níveis 5S (sistemas, sumários, sinopses, sínteses e estudos) de organização de evidência de pesquisa em saúde, com base no modelo proposto por Haynes. Os termos de busca foram Tourette, tiques e comorbidades, completados por pesquisa por referência cruzada. Os artigos fornecidos pelos editores e aqueles a serem processados para publicação em 31 de julho de 2013 também foram incluídos. Resultados: De todos os artigos encontrados durante a pesquisa, 64 foram selecionados porque analisavam a epidemiologia, as características clínicas e a etiopatogenia da ST. A ST define-se como um distúrbio hipercinético do movimento, e pelo menos 90% dos pacientes apresentam comorbidades neuropsiquiátricas, das quais as mais comuns são a perturbação de déficit de atenção com hiperatividade e a perturbação obsessivo--compulsiva. Esta síndrome é clinicamente heterogênea e tem sido relacionada com a disfunção dos circuitos córtico-estriado--tálamo-corticais envolvendo vários neurotransmissores. Apesar de sua etiologia genética ter sido amplamente estudada, outros fatores podem ser importantes para entender esta síndrome e as perturbações relacionadas. Conclusões: A ST resulta de uma p...

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Section: Other Comorbiditiessupporting

confidence: 71%

Tourette's syndrome and associated disorders: a systematic review

Ferreira

Pio-Abreu

Januário

2014

Trends Psychiatry Psychother.

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“…TS has a prevalence of 1% in general population and 3/4 of the patients are male (Staley et al, 1997). The age of onset of the disease ranges from 2 to 14 years old with a peak age of tic onset at 6–7 years of age (Kerbeshian et al, 2009; Robinson, 2010). TS is often comorbid with other neuropsychiatric disorders such as attention deficit/hyperactivity disorder and obsessive-compulsive disorder (Cavanna et al, 2009).…”

Section: Altered Mirna Expression and Function In Various Neuropsymentioning

confidence: 99%

MicroRNA dysregulation in neuropsychiatric disorders and cognitive dysfunction

Hsu

Karayiorgou

et al. 2012

Neurobiology of Disease

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MicroRNAs (miRNA), a class of non-coding RNAs, are emerging as important modulators of neuronal development, structure and function. A connection has been established between abnormalities in miRNA expression and miRNA-mediated gene regulation and psychiatric and neurodevelopmental disorders as well as cognitive dysfunction. Establishment of this connection has been driven by progress in elucidating the genetic etiology of these phenotypes and has provided a context to interpret additional supporting evidence accumulating from parallel expression profiling studies in brains and peripheral blood of patients. Here we review relevant evidence that supports this connection and explore possible mechanisms that underlie the contribution of individual miRNAs and miRNA-related pathways to the pathogenesis and pathophysiology of these complex clinical phenotypes. The existing evidence provides useful hypotheses for further investigation as well as important clues for identifying novel therapeutic targets.

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“…Among the various comorbidities, schizophrenia is less commonly reported. In a study involving 399 TS patients, schizophrenia was seen in 2.5% of cases [12]. Other studies have reported prevalence of schizophrenia like symptom in about 11-12% [7,13] and schizotypal or schizoid personality disorders in 13-15% of patients with TS [14,15].…”

Section: Discussionmentioning

confidence: 96%

Relapse of Tourette Syndrome with Clozapine in a Patient of Paranoid Schizophrenia

Grover¹,

Pokhrel²,

Kate³

2012

J Clinic Case Reports

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Tourette syndrome (TS) is characterized by multiple motor and vocal tics and is commonly associated obsessiveCompulsive Disorder (OCD). Comorbidity between TS and schizophrenia has been less commonly described. In this case report a case of schizophrenia with comorbid TS is described in which symptoms of TS relapsed when the patient was started on clozapine. Exacerbation of TS with clozapine has been reported in few case reports in the literature. Our case highlights the fact that clozapine should be used with caution in patients with schizophrenia who have tic disorder.

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Tourette syndrome and comorbid early-onset schizophrenia

Cited by 32 publications

References 46 publications

Tourette's syndrome and associated disorders: a systematic review

Tourette's syndrome and associated disorders: a systematic review

MicroRNA dysregulation in neuropsychiatric disorders and cognitive dysfunction

Relapse of Tourette Syndrome with Clozapine in a Patient of Paranoid Schizophrenia

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