Relationships of depression and anxiety symptoms with seizure frequency: Results from a multicenter follow-up study

Dehn, Lorenz B.; Pfäfflin, Margarete; Brückner, Sabine; Lutz, M.; Steinhoff, Bernhard J.; Mayer, Thomas; Bien, Christian G.; Nußbeck, Fridtjof W.; May, Theodor W.

doi:10.1016/j.seizure.2017.11.008

Cited by 29 publications

(20 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, this result is in line with an increased prevalence of anxiety disorders in patients with epilepsy . Of interest, a recent study reported a correlation between seizure frequency and anxiety levels in patients . Thus our data during kindling progression seem to reflect the respective psychiatric comorbidity in patients with uncontrolled seizure activity.…”

Section: Discussionsupporting

confidence: 86%

“…25,26 Of interest, a recent study reported a correlation between seizure frequency and anxiety levels in patients. 27 Thus our data during kindling progression seem to reflect the respective psychiatric comorbidity in patients with uncontrolled seizure activity. However, in this context, the lack of a significant difference between electrode-implanted rats and kindled rats needs to be considered for interpretation.…”

Section: Discussionmentioning

confidence: 69%

See 1 more Smart Citation

Toward evidence‐based severity assessment in rat models with repeated seizures: I. Electrical kindling

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 69%

Toward evidence‐based severity assessment in rat models with repeated seizures: I. Electrical kindling

et al. 2018

View full text Add to dashboard Cite

show abstract

“…However, the higher the level of education was, the lower the incidence of depression has been recorded [39]. Single patients with epilepsy may be at a greater risk for depression compared to those who are married [40], although a link between marital status and depression in patients with epilepsy had not been always confirmed [37].Regarding epilepsy characteristics, seizure frequency has been found to be strongly associated with depression [36,41]. Polypharmacy has been suggested as a risk factor for depression in epilepsy [39], although there are also studies that have not confirmed it [36,37].…”

Section: Depressionmentioning

confidence: 99%

Depression and quality of life in patients with epilepsy in Northwest Greece

Siarava

Hyphantis

Katsanos

et al. 2019

Seizure

View full text Add to dashboard Cite

The purpose of the present study was to compare depression and QoL between patients with epilepsy and healthy controls, evaluating potentially related factors to depression and QoL in patients with epilepsy in Northwest Greece. Methods: A case study was conducted in adult patients with epilepsy followed up at the University Hospital of Ioannina and in healthy controls. The Patient Health Questionnaire (PHQ-9) for depression's severity evaluation, the WHOQOL-BREF questionnaire for the QoL estimation and the Adverse Event Profile (AEP) questionnaire for the Antiepileptic Drugs (AEDs) adverse effects assessment were used. Results: Seventy patients with epilepsy and 70 controls were recruited. The PHQ-9 score was higher in patients compared to controls and slightly higher than reported in patients with epilepsy. PHQ-9 was significantly associated with the AEP score. Our patients had a poorer QoL compared to controls. The level of education, the AEP and the PHQ-9 scores were associated to QoL, the last two being the most powerful predictors of QoL. Conclusion: Patients with epilepsy in Northwest Greece had higher rates of depression than reported in patients with epilepsy and poorer QoL compared to controls. The adverse effects of AEDs were related to depression in our study, while the adverse effects of AEDs and depression were more powerful predictors of QoL compared to demographics and other characteristics of epilepsy.

show abstract

“…This is in contrast with recent findings by Dehn et al 28 who demonstrated that a higher seizure frequency was significantly correlated with anxiety in patients with difficultto-treat epilepsy (but without cognitive impairments) admitted to an epilepsy center. This difference might be explained by the fact that all our patients are living at a tertiary epilepsy center and that their seizure frequency is higher than in the study by Dehn et al 28 it could be hypothesized that the patients are therefore more habituated to having seizures and to its consequences in daily life. Also, professional caregivers who are specialized in epilepsy are always in close proximity and provide care and attention to patients who have seizures.…”

Section: Discussionmentioning

confidence: 59%

“…This seems to conflict with some studies on epilepsy and depression in patients without ID, suggesting that depression is associated with epilepsy-related characteristics. 28,29 However, a review study by Hoppe and Elger concluded that the overall evidence is weak if stress-related epilepsy factors, such as social stigma, are taken into account. 30 Finally, despite the small subsample size, our findings confirm that a more severe epilepsy is associated with poorer quality of life regarding the domain of psychological functioning, which seems to emphasize the burden of epilepsy in their daily life.…”

Section: Discussionmentioning

confidence: 99%

Mood, anxiety, and perceived quality of life in adults with epilepsy and intellectual disability

Snoeijen‐Schouwenaars

Ool

Tan

et al. 2019

Acta Neurol Scand

View full text Add to dashboard Cite

Both depression and anxiety disorders are relatively common psychiatric disorders in patients with epilepsy. Pooled prevalence rates in this population are estimated at 22.9% and 20.2%, 1 which is much higher when compared to the prevalence of depression and anxiety disorders worldwide (4.4% and 3.6%). 2 Although epilepsy relatively often co-occurs with intellectual disability (ID), 3 literature on the presence of mood disorders among patients with both epilepsy and ID is scarce. Knowledge of this relationship is important as it might influence quality of life in these patients.Depressive and anxiety symptoms can be associated with epilepsy for multiple reasons. They may have the same underlying neurobiological aetiology 4 or result from epilepsy due to seizure-related or psychosocial factors, such as increased dependence, experienced stigma, and poor seizure control. 5,6 Results from a systematic review indicate that having an epilepsy diagnosis is associated with an increase of depressive symptoms in adults with ID and that a severe Objective: Depression and anxiety symptoms are common among patients with epilepsy, but are relatively under-researched in patients with both epilepsy and intellectual disability (ID). The aim was to investigate whether epilepsy and ID characteristics are associated with mood, anxiety, and quality of life. Materials and Methods:Adult patients with epilepsy and ID who rely on tertiary epilepsy care were included (N = 189). Mood, anxiety, and quality of life were assessed by standardized questionnaires. Epilepsy and ID characteristics were retrieved from patient charts or determined by psychometric instruments.Results: Elevated levels of depressive and anxiety symptoms were present in 21.7% and 12.7%, respectively. Anxiety was significantly associated with a focal epilepsy type and ID domain discrepancy (substantial difference between two domains of adaptive behavior), but was negatively related to seizure frequency and drug load of mood-stabilizing antiepileptic drugs. Depressive symptoms were not significantly related to epilepsy characteristics, but a severe ID and ID domain discrepancy was associated with more depressive symptoms. Quality of life was significantly worse in those with multiple seizure types and ID domain discrepancy. Conclusion:Whereas anxiety and quality of life are associated with individual epilepsy characteristics, this could not be confirmed for depressive symptoms in patients with epilepsy and ID, despite its high prevalence. K E Y W O R D S anxiety disorder, depression, developmental disability, mental health, seizures How to cite this article: Snoeijen-Schouwenaars FM, van Ool JS, Tan IY, Aldenkamp AP, Schelhaas HJ, Hendriksen JGM. Mood, anxiety, and perceived quality of life in adults with epilepsy and intellectual disability. Acta Neurol Scand.

show abstract

Relationships of depression and anxiety symptoms with seizure frequency: Results from a multicenter follow-up study

Cited by 29 publications

References 41 publications

Toward evidence‐based severity assessment in rat models with repeated seizures: I. Electrical kindling

Toward evidence‐based severity assessment in rat models with repeated seizures: I. Electrical kindling

Depression and quality of life in patients with epilepsy in Northwest Greece

Mood, anxiety, and perceived quality of life in adults with epilepsy and intellectual disability

Contact Info

Product

Resources

About