Relationships of serum lipid profiles and bone mineral density in postmenopausal Chinese women

Li, Shuang; Hong-bing, Guo; Liu, You‐Shuo; Wu, Feng; Zhang, Hongbing; Zhang, Zhimin; Xie, Zhongjian; Sheng, Zhifeng; Liao, Er-Yuan

doi:10.1111/cen.12616

Cited by 72 publications

(48 citation statements)

References 37 publications

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“… 38 , 41 In some studies, serum TG and HDL-C were found to be correlated with BMD, but no relationship was seen between either TC or LDL-C and BMD. 42 – 44 Li et al 44 only focused on the postmenopausal Chinese women; however, our studies focused on both men and women aged 40–95 years old, where data on this population are scarce. This is population-based and included a relatively large sample size.…”

Section: Discussionmentioning

confidence: 98%

Assessment risk of osteoporosis in Chinese people: relationship among body mass index, serum lipid profiles, blood glucose, and bone mineral density

Cui¹,

Zhou²,

Li³

et al. 2016

CIA

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ObjectiveThe aim of our study was to investigate the relationship among age, sex, body mass index (BMI), serum lipid profiles, blood glucose (BG), and bone mineral density (BMD), making an assessment of the risk of osteoporosis.Materials and methodsA total of 1,035 male and 3,953 female healthy volunteers (aged 41–95 years) were recruited by an open invitation. The basic information, including age, sex, height, weight, waistline, hipline, menstrual cycle, and medical history, were collected by a questionnaire survey and physical examination. Serum lipid profiles, BG, postprandial blood glucose, and glycosylated hemoglobin were obtained after 12 hours fasting. BMD in lumbar spine was measured by dual-energy X-ray absorptiometry scanning.ResultsThe age-adjusted BMD in females was significantly lower than in males. With aging, greater differences of BMD distribution exist in elderly females than in males (P<0.001), and the fastigium of bone mass loss was in the age range from 51 to 55 in females and from 61 to 65 years in males. After adjustment for sex, there were significant differences in BMD among BMI-stratified groups in both males and females. The subjects with a BMI of <18.5 had a higher incidence of osteoporosis than BMI ≥18.5 in both sexes. BMD in type 2 diabetes mellitus with a BG of >7.0 mmol/L was lower than in people with BG of ≤7.0 mmol/L (P<0.001). People with serum high-density lipoprotein cholesterol levels of ≥1.56 mmol/L had a greater prevalence of osteoporosis compared with high-density lipoprotein cholesterol ≤1.55 mmol/L. Logistic regression with odds ratios showed that no association was found among total cholesterol, triglyceride, low-density lipoprotein cholesterol, glycosylated hemoglobin, postprandial blood glucose and BMD.ConclusionThe present study further confirmed that factors such as age, sex, weight, BMI, high-density lipoprotein cholesterol, and diabetes are significant predictors of osteoporosis in the Chinese people.

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Section: Discussionmentioning

confidence: 98%

Assessment risk of osteoporosis in Chinese people: relationship among body mass index, serum lipid profiles, blood glucose, and bone mineral density

Cui¹,

Zhou²,

Li³

et al. 2016

CIA

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“…Somehow, HDL-C showed a weak relationship with BMD (β = 0.151, P = 0.034). Since a latest report has determined some effects of HDL-C on bone fragility 32 ; and D’Amelio et al also suggested that HDL was significantly higher in osteoporotic patients than controls, the level of HDL could be used as screening for postmenopausal osteoporosis 33 . However, the exact relationship requires further studies.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Fat distribution and Bone quality with Trabecular Bone Score (TBS) in Healthy Chinese Men

Zhang

et al. 2016

Sci Rep

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Whether fat is beneficial or detrimental to bones is still controversial, which may be due to inequivalence of the fat mass. Our objective is to define the effect of body fat and its distribution on bone quality in healthy Chinese men. A total of 228 men, aged from 38 to 89 years, were recruited. BMD, trabecular bone score (TBS), and body fat distribution were measured by dual-energy X-ray absorptiometry. Subcutaneous and visceral fat were assessed by MRI. In the Pearson correlation analysis, lumbar spine BMD exhibited positive associations with total and all regional fat depots, regardless of the fat distribution. However, the correlation disappeared with adjusted covariables of age, BMI, HDL-C, and HbA1c%. TBS was negatively correlated with fat mass. In multiple linear regression models, android fat (and not gynoid, trunk, or limbs fat) showed significant inverse association with TBS (β = −0.611, P < 0.001). Furthermore, visceral fat was described as a pathogenic fat harmful to TBS, even after adjusting for age and BMI (β = −0.280, P = 0.017). Our findings suggested that body fat mass, especially android fat and visceral fat, may have negative effects on bone microstructure; whereas body fat mass contributes to BMD through mechanical loading.

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“…Substantial data showed a negative association between BMD and serum TC, and LDL cholesterol ( 5 , 7 , 8 , 92 – 97 ). A few studies found no association and/or a positive association with serum cholesterol and LDL cholesterol ( 98 – 101 ). The summarized data from all the studies indicate that there is an existence of an inconsistent relationship for the case of HDL cholesterol and BMD ( 6 , 99 , 100 , 102 ).…”

Section: Discussionmentioning

confidence: 99%

High Cholesterol Deteriorates Bone Health: New Insights into Molecular Mechanisms

Mandal

2015

Front. Endocrinol.

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Many epidemiological studies show a positive connection between cardiovascular diseases and risk of osteoporosis, suggesting a role of hyperlipidemia and/or hypercholesterolemia in regulating osteoporosis. The majority of the studies indicated a correlation between high cholesterol and high LDL-cholesterol level with low bone mineral density, a strong predictor of osteoporosis. Similarly, bone metastasis is a serious complication of cancer for patients. Several epidemiological and basic studies have established that high cholesterol is associated with increased cancer risk. Moreover, osteoporotic bone environment predisposes the cancer cells for metastatic growth in the bone microenvironment. This review focuses on how cholesterol and cholesterol-lowering drugs (statins) regulate the functions of bone residential osteoblast and osteoclast cells to augment or to prevent bone deterioration. Moreover, this study provides an insight into molecular mechanisms of cholesterol-mediated bone deterioration. It also proposes a potential mechanism by which cellular cholesterol boosts cancer-induced bone metastasis.

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Relationships of serum lipid profiles and bone mineral density in postmenopausal Chinese women

Abstract: In Chinese postmenopausal women, elevated levels of serum HDL-C had a greater probability of being osteoporosis than the lower HDL-C levels. Our analysis showed higher HDL-C level that is favourable for cardiovascular diseases should be regarded as a risk factor for osteoporosis.

Cited by 72 publications

References 37 publications

Assessment risk of osteoporosis in Chinese people: relationship among body mass index, serum lipid profiles, blood glucose, and bone mineral density

Assessment risk of osteoporosis in Chinese people: relationship among body mass index, serum lipid profiles, blood glucose, and bone mineral density

Assessment of Fat distribution and Bone quality with Trabecular Bone Score (TBS) in Healthy Chinese Men

High Cholesterol Deteriorates Bone Health: New Insights into Molecular Mechanisms

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