Relative Affinity M Constant of Adult and Fetal Hemoglobin for Carbon Monoxide in Humans: a Systematic Review and Meta-Analysis

Delvau, N.; Penaloza, Andréa; Liistro, Giuseppe; Thys, F.; Mégarbane, Bruno; Hantson, Philippe; Roy, Pierre‐Marie

doi:10.1134/s0362119720020048

Cited by 2 publications

(1 citation statement)

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“…Furthermore, despite the fact that we applied the ERC guidelines [20], arterial pH was less than 7.0 during CPR. With this acidity level, we suspect a lower affinity of Hb for CO, even if we did not confirm this hypothesis in a recent meta-analysis [30].…”

Section: Discussioncontrasting

confidence: 67%

Unexpected carboxyhemoglobin half-life during cardiopulmonary resuscitation: a case report

et al. 2023

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Background Cardiac arrest (CA) following CO poisoning (CO-induced CA) exposes patients to an extremely high risk of mortality and remains challenging to treat effectively. Terminal carboxyhemoglobin elimination half-life (COHbt1/2) is critically affected by ventilation, oxygen therapy, and cardiac output, which are severely affected conditions in cases of CA. Case presentation Asystole occurred in an 18-year-old woman after unintentional exposure to CO in her bathroom. Cardiopulmonary resuscitation (CPR) was started immediately, including mechanical ventilation with a fraction of inspired oxygen (FiO2) of 1.0 and external chest compressions with a LUCAS® device. CPR was stopped after 101 min, as it was unsuccessful. During this period, we calculated a COHbt1/2 of 40.3 min using a single compartmental model. Conclusions This result suggests that prolongation of CPR time needed to back COHb at 10%, a level more compatible with successful return of spontaneous circulation (ROSC), could be compatible with a realistic CPR time. Calculating COHbt1/2 during CPR may help with decision-making regarding the optimal duration of resuscitation efforts and further with HBO2 or ECLS. Further evidence-based data are needed to confirm this result.

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Section: Discussioncontrasting

confidence: 67%