Relative Antidepressant Efficacy of Venlafaxine and SSRIs: Sex-Age Interactions

Thase, Michael E.; Entsuah, Richard; Cantillon, Marc; Kornstein, Susan G.

doi:10.1089/jwh.2005.14.609

Cited by 183 publications

(132 citation statements)

References 23 publications

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“…However, studies focused on SSRIs in larger patient populations, such as a study of citalopram in the Sequenced Treatment Alternatives to Relieve Depression, or STAR*D trial, document significantly larger treatment effects among women relative to men (Young et al 2009). Furthermore, differential effects of antidepressants by gender have been concentrated among patients under age 50, leading some to hypothesize that hormonal activity affects the efficacy of antidepressants (Thase et al 2005). These differences are too small to explain the dramatic effects for girls versus boys, though.…”

Section: Alternative Interpretation Of the Resultsmentioning

confidence: 99%

The FDA and ABCs: Unintended Consequences of Antidepressant Warnings on Human Capital

Busch¹,

Golberstein²,

Meara³

2014

Journal of Human Resources

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Using annual cross-sectional data on over 100,000 adolescents aged 12-17, we studied academic and behavioral outcomes among those who were and were not likely affected by FDA warnings regarding the safety of antidepressants. Compared to other adolescents, adolescents with probable depression experienced a relative decline in grade point average of .14 points following the FDA warnings. The FDA warnings also coincided with increased delinquency, use of tobacco and use of illicit drugs. Together, our results stress the importance of mental health and its treatment as an input into cognitive and non-cognitive aspects of human capital.

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Section: Alternative Interpretation Of the Resultsmentioning

confidence: 99%

The FDA and ABCs: Unintended Consequences of Antidepressant Warnings on Human Capital

Busch¹,

Golberstein²,

Meara³

2014

Journal of Human Resources

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“…20 Women respond better to selective serotonin reuptake inhibitors than men. 22 Differences related to menopausal status have also been noted, with postmenopausal women responding more poorly to selective serotonin reuptake inhibitors than premenopausal women, 23 and premenopausal women responding poorly to tricyclic antidepressants. 24 Premenstrual disorders (PMD) are prototypical femalespecific disorders that include premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), and premenstrual exacerbation (PME) of ongoing affective disorders such as dysthymia and major and minor depression.…”

Section: Depressive Disorders Including Premenstrual Disordersmentioning

confidence: 99%

Effects of Sex and Gender on Adaptation to Space: Behavioral Health

Goel

BaleTracy

Neill

et al. 2014

Journal of Women's Health

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This article is part of a larger body of work entitled, ''The Impact of Sex and Gender on Adaptation to Space.'' It was developed in response to a recommendation from the 2011 National Academy of Sciences Decadal Survey, ''Recapturing a Future for Space Exploration: Life and Physical Sciences for a New Era,'' which emphasized the need to fully understand sex and gender differences. In this article, our workgroup-consisting of expert scientists and clinicians from academia and the private sector-investigated and summarized the current body of published and unpublished human research performed to date related to sex-and gender-based differences in behavioral adaptations to human spaceflight. This review identifies sex-related differences in: (1) sleep, circadian rhythms, and neurobehavioral measures; (2) personality, group interactions, and work performance and satisfaction; and (3) stress and clinical disorders. Differences in these areas substantially impact the risks and optimal medical care required by space-faring women. To ensure the health and safety of male and female astronauts during long-duration space missions, it is imperative to understand the influences that sex and gender have on behavioral health changes occurring during spaceflight.

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“…Research is needed to determine whether comorbidities influence sex/gender differences in the effectiveness and side effects of specific treatments. For example, selective serotonin reuptake inhibitors (SSRIs) are more effective for women than for men for depression [106,197]; research is needed to determine whether this difference holds when SSRIs are used for pain. …”

mentioning

confidence: 99%

Studying sex and gender differences in pain and analgesia: A consensus report

Greenspan

Craft

LeResche

et al. 2007

Pain

871

633

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In September 2006, members of the Sex, Gender and Pain Special Interest Group of the International Association for the Study of Pain met to discuss the following: (1) what is known about sex and gender differences in pain and analgesia; (2) what are the "best practice" guidelines for pain research with respect to sex and gender; and (3) what are the crucial questions to address in the near future? The resulting consensus presented herein includes input from basic science, clinical and psychosocial pain researchers, as well as from recognized experts in sexual differentiation and reproductive endocrinology. We intend this document to serve as a utilitarian and thought-provoking guide for future research on sex and gender differences in pain and analgesia, both for those currently working in this field as well as those still wondering, "Do I really need to study females?" Keywords Sex differences; Gonadal hormones; Estrogens The case for studying sex and gender differences in pain and analgesiaThe pain field has moved from debating whether sex differences in pain exist to recognizing the importance of these differences. Attention is now directed toward understanding (1) what conditions lead to the expression of sex and gender differences in pain experience and reactivity, (2) what mechanisms underlie these differences, and (3) how these differences can inform clinical management of pain.As noted in a recent review, at least 79% of animal studies published in Pain over the preceding 10 years included male subjects only, with a mere 8% of studies on females only, and another 4% explicitly designed to test for sex differences (the rest did not specify) [142]. Given the substantially greater prevalence of many clinical pain conditions in women vs. men [20,199], and growing evidence for sex differences in sensitivity to experimental pain and to analgesics [21,41,213], we recommend that all pain researchers consider testing their hypotheses in both sexes, or if restricted by practical considerations, only in females. It is invalid to assume that data obtained in male subjects will generalize to females, and the best non-human model of the modal human pain sufferer -a woman -is a female animal. If only males are examined in a given study, it is important that a rationale for exclusion of females be provided and that the potential limitation in generalizability of the findings be addressed in the discussion, particularly when examining a pain phenomenon that occurs with greater prevalence or severity in females. In both preclinical and clinical studies, a comparison of both sexes will further our understanding of individual differences in sensitivity to pain and analgesia, thus improving our ability to treat and prevent pain in all people. General considerationsTwo issues of terminology are important. First, the term "sex" refers to biologically based differences, while the term "gender" refers to socially based phenomena. Although biological sex exerts a major influence on one's gender identity, sex and gender a...

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Relative Antidepressant Efficacy of Venlafaxine and SSRIs: Sex-Age Interactions

Abstract: These findings provide further evidence that age, gender, and HRT moderate response to antidepressant medications.

Cited by 183 publications

References 23 publications

The FDA and ABCs: Unintended Consequences of Antidepressant Warnings on Human Capital

The FDA and ABCs: Unintended Consequences of Antidepressant Warnings on Human Capital

Effects of Sex and Gender on Adaptation to Space: Behavioral Health

Studying sex and gender differences in pain and analgesia: A consensus report

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