Relative Bioavailability of Tropical Volcanic Soil-Bound Chlordecone in Piglets

Bouveret, Cécile; Rychen, Guido; Lerch, Sylvain; Jondreville, Catherine; Feidt, Cyril

doi:10.1021/jf400697r

Cited by 20 publications

(14 citation statements)

References 26 publications

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“…These differences between both organs are consistent with previous observations in rodent [28], lambs [8], pigs [9] and humans [29]. This particular affinity of CLD to liver could be explained by non-clearly identified proteins which readily bound CLD [30].…”

Section: Resultssupporting

confidence: 90%

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Activated carbon, a useful medium to bind chlordecone in soil and limit its transfer to growing goat kids

et al. 2017

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Chlordecone (Kepone) (CLD) is a highly persistent pesticide which was extensively used in the French West Indies; high levels of CLD can still currently be found in large agricultural areas. As CLD transfers from soil to animals mainly via involuntary ingestion, the consumption of foodstuffs derived from animals raised in contaminated areas may significantly contribute to exposure of humans to CLD. The present study was designed to test the efficacy of two different activated carbons (ACs) sources in limiting CLD transfer from soil to animal. Three soils (ASs) were prepared according to the OECD guideline 207. One standard soil (SS) lacking AC, and two modified preparations of SS supplemented with 2% coconut-based activated carbon (ORBO), SSO or with 2% lignite-based one (DARCO), SSD. All three soils were spiked with 10 μg of kepone per g of dry matter and aged for three weeks. This study involved 15 goat kids randomly assigned to the 3 experimental groups (n = 5/group), which were fed the experimental matrices at an exposure dose of 10 μg CLD per kg of body weight per day. After 21 d of oral exposure, CLD in adipose tissue and liver were analysed by LC-MS-MS. A significant decrease of 63.7% and 74.7% of CLD concentrations in adipose tissue and liver, respectively, were obtained from animals exposed using SS containing DARCO as compared to those receiving only SS. Decreases in CLD levels of 98.2% (adipose tissue) and 98.7% (liver) were obtained for animals exposed using SS containing ORBO. This study leads us to conclude that (i) the presence of AC in CLD-contaminated soil strongly reduces CLD bioavailability, and (ii) the efficacy depends on the nature and characteristics of the AC used.

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Section: Resultssupporting

confidence: 90%

“…CLD-transfer to lambs [8], piglets [9] and laying hens [10] have been proven to not be limited by the type and properties of Antillean soils (nitisol or andosol). The specific efficiency of this transfer is related to the availability of this pesticide for outdoor reared animals.…”

Section: Introductionmentioning

confidence: 99%

Activated carbon, a useful medium to bind chlordecone in soil and limit its transfer to growing goat kids

et al. 2017

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“…Comparison between oil-fed and soil-fed animals groups was realized in order to assess exposure to spiked soil with OM in terms of exposure via the alimentary one. Similar methodology was previously used [19] – [21] . The present study provides RBA estimates using a single dose comprised in a linearity-tested range of doses [17] .…”

Section: Methodsmentioning

confidence: 96%

Effects of Standard Humic Materials on Relative Bioavailability of NDL-PCBs in Juvenile Swine

et al. 2014

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Young children with their hand-to-mouth activity may be exposed to contaminated soils. However few studies assessing exposure of organic compounds sequestrated in soil were realized. The present study explores the impact of different organic matters on retention of NDL-PCBs during digestive processes using commercial humic substances in a close digestive model of children: the piglet. Six artificial soils were used. One standard soil, devoid of organic matter, and five amended versions of this standard soil with either fulvic acid, humic acid, Sphagnum peat, activated carbon or a mix of Sphagnum peat and activated carbon (95∶5) (SPAC) were prepared. In order to compare the different treatments, we use spiked oil and negative control animals. Forty male piglets were randomly distributed in 7 contaminated and one control groups (n = 5 for each group). During 10 days, the piglets were fed artificial soil or a corn oil spiked with 19 200 ng of Aroclor 1254 per g of dry matter (6 000 ng.g−1 of NDL-PCBs) to achieve an exposure dose of 1 200 ng NDL-PCBs.Kg−1 of body weight per day. NDL-PCBs in adipose tissue were analyzed by GC-MS. Fulvic acid reduced slightly the bioavailability of NDL-PCBs compared to oil. Humic acid and Sphagnum peat reduced it significantly higher whereas activated carbon reduced the most. Piglets exposed to soil containing both activated carbon and Shagnum peat exhibited a lower reduction than soil with only activated carbon. Therefore, treatment groups are ordered by decreasing value of relative bioavailability as following: oil ≥ fulvic acid>Sphagnum peat ≥ Sphagnum peat and activated carbon ≥ Humic acid>>activated carbon. This suggests competition between Sphagnum peat and activated carbon. The present study highlights that quality of organic matter does have a significant effect on bioavailability of sequestrated organic compounds.

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“…This extended rearing duration exposes them to an absolute soil intake higher than for NRES animals. Based on literature (Bouveret et al, 2013;Jurjanz et al, 2014) soil intake by animals observed during our experiment would result in CLD contamination when the animals would have grazed on polluted areas.…”

Section: Soil Intakementioning

confidence: 94%

“…Therefore, the exposure of free range animals to pollutants is closely linked to the amount of soil ingested which can be particularly high for some ruminants, up to 14% of the daily dry matter intake (DMI) in cattle (Fries et al, 1982), and up to 30% of DMI in sheep (Thornton and Abrahams, 1983) reported on pastures in very extensive temperate systems. Several authors reported that soil-bound persistent organic pollutants such as polychlorinated biphenyls in lactating goats and piglets (Delannoy et al, 2015), but also for chlordecone (CLD) in piglets (Bouveret et al, 2013) and growing lambs (Jurjanz et al, 2014) are highly bioavailable and fully absorbed in the digestive tract. Consequently, an accurate quantification of soil intake is required to evaluate the risk for food safety.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of soil intake by growing Creole young bulls in common grazing systems in humid tropical conditions

Jurjanz

Collas

Lastel

et al. 2017

Animal

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Soil is the main matrix which contributes to the transfer of environmental pollutants to animals and consequently into the food chain. In the French West Indies, chlordecone, a very persistent organochlorine pesticide, has been widely used on banana growing areas and this process has resulted in a long-term pollution of the corresponding soils. Domestic outside-reared herbivores are exposed to involuntary soil intake, and tethered grazing commonly used in West Indian systems can potentially favour their exposure to chlordecone. Thus, it appears necessary to quantify to what extent grazing conditions will influence soil intake. This experiment consisted of a cross-over design with two daily herbage allowance (DHA) grazed alternatively. Six young Creole bulls were distributed into two groups (G1 and G2) according to their BW. The animals were individually tethered and grazed on a restrictive (RES) or non-restrictive (NRES) levels of DHA during two successive 10-days periods. Each bull progressed on a new circular area every day. The two contrasting levels of DHA (P < 0.001) were obtained via a different daily grazing surface area (RES: 20 m 2 /animal, NRES: 31 m 2 /animal; P < 0.01) offered to the animals by the modulation of the length of the tethering chain (RES: 1.9 m, NRES: 2.6 m). These differences in offered grazing areas resulted in DHA of 71 and 128 g DM/kg BW 0.75 , respectively for RES and NRES treatments. As expected, the animals grazing on the reduced area realized a lower daily dry matter intake (DMI) (RES: 1.12 kg/100 kg BW, NRES: 1.83 kg/100 kg BW; P < 0.05) and present a lower organic matter digestibility (RES: 0.67, NRES: 0.73; P < 0.01) than NRES ones, due in part to the shorter post-grazing sward surface height (RES: 3.3 cm, NRES: 5.2 cm; P < 0.01) of their grazing circles. Soil intake was estimated on an individual level based on the ratio of the marker titanium in soil, herbage and faeces. Grazing closer to the ground, animals on RES treatment ingested a significantly higher proportion of soil in their total DMI (RES: 9.3%, NRES: 4.4%; P < 0.01). The amount of ingested soil in the diet was not significantly different between the two treatments (RES: 98 g/100 kg BW, NRES: 78 g/100 kg BW; P > 0.05) due to the lower DMI of RES compared with NRES treatment.

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Relative Bioavailability of Tropical Volcanic Soil-Bound Chlordecone in Piglets

Cited by 20 publications

References 26 publications

Activated carbon, a useful medium to bind chlordecone in soil and limit its transfer to growing goat kids

Activated carbon, a useful medium to bind chlordecone in soil and limit its transfer to growing goat kids

Effects of Standard Humic Materials on Relative Bioavailability of NDL-PCBs in Juvenile Swine

Evaluation of soil intake by growing Creole young bulls in common grazing systems in humid tropical conditions

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