Relative Deficiency of Anti-Inflammatory N-Acylethanolamines Compared to Prostaglandins in Oral Lichen Planus

Rankin, Linda; Gouveia-Figueira, Sandra; Danielsson, Karin; Fowler, Christopher J.

doi:10.3390/biomedicines8110481

Cited by 4 publications

(5 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prostaglandins produced by PTGS2 can enhance inflammation, bone resorption, and tissue destruction in the periodontal area [ 48 ]. Additionally, an imbalance between prostaglandins and N-acylethanolamines has been reported in humans with OLP [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Feline Chronic Gingivostomatitis Diagnosis and Treatment through Transcriptomic Insights

Soltero-Rivera,

Shaw,

Arzi

et al. 2024

Pathogens

View full text Add to dashboard Cite

Feline chronic gingivostomatitis (FCGS) is a debilitating inflammatory oral mucosal disease with a multifactorial etiology. The clinical diagnosis of FCGS is made based on inspection of severe inflammatory lesions and histological confirmation rather than a molecular diagnostic outcome. This gap limits the ability to provide an early diagnosis. In this report, we seek to provide additional diagnostic tools using genomics to aid in providing clinically relevant information. The use of in-depth diagnostic tools, like transcriptomics of diseased tissues, to diagnose FCGS and stratify patients into predictive treatment response groups would dramatically improve both clinical decisions and patient outcomes. In this study, we addressed the gap in diagnostic options using transcriptomic analysis of caudal oral mucosal swab specimens coupled to detailed medical record linkage of FCGS-affected cats undergoing tooth extractions and in some cases administration of mesenchymal stromal cells (MSCs). To better identify markers of disease and potential response to treatment, the transcriptomes of FCGS-afflicted cats were compared to those of healthy cats and those with chronic periodontitis to clearly establish diagnostic biomarker signal transduction connections. Phosphatidylinositol 3-kinase/Ak strain transforming (PI3K/AKT) and stress-activated protein kinases/Jun N-terminal kinase (SAP/JNK) signaling pathways were significantly differentially regulated in FCGS-afflicted cats. Activation of these pathways also differed in the treatment response groups. In conjunction, the enzymes Caspase 4 (CASP4), matrix metalloproteinase-8 (MMP8), and prostaglandin-endoperoxide synthase 2 (PTGS2) were identified as potential biomarkers for the prediction of treatment response outcomes. The observations in the case study support the use of transcriptomics of FCGS patients to contribute to improved molecular diagnostics for the diagnosis and treatment of FCGS.

show abstract

Section: Discussionmentioning

confidence: 99%

Feline Chronic Gingivostomatitis Diagnosis and Treatment through Transcriptomic Insights

Soltero-Rivera,

Shaw,

Arzi

et al. 2024

Pathogens

View full text Add to dashboard Cite

show abstract

“…It is known that PEA treatment, both in vivo and in vitro, can modulate COX-2 and PGs derived from it [84] and that COX-2 and PG levels are increased in OLP [35]. A recent study, which investigated the NAE system in relation to OLP, found that PEA synthesis is insufficiently mobilized in OLP to counterbalance the increased expression of COX-2 [84].…”

Section: Palmitoylethanolamide In the Management Of Diseases Of Denta...mentioning

confidence: 99%

“…This insufficient mobilization of an endogenous, PEA-induced response to dampen inflammation in OLP opens the possibility that exogenous PEA could be a potentially useful treatment strategy for this disorder, given its anti-inflammatory properties (not least its ability to downmodulate mast cells to reduce inflammatory cytokine levels secondary to its effects on PPAR-α). Therefore, a clinical trial of appropriate local or systemic PEA treatment would greatly impact OLP [35].…”

Section: Palmitoylethanolamide In the Management Of Diseases Of Denta...mentioning

confidence: 99%

“…The addition of PEA-containing nutraceutical agents to scaling and root planning (SRP) in the treatment of periodontal disease appears to provide improvements in clinical and inflammatory parameters as well as post-treatment pain compared with SRP alone [32]. The use of exogenous PEA for the treatment of OLP needs further investigation for adequate treatment, as a reduction in inflammation in the disease by its local or systemic use has emerged [35]. In BMS, PEA provided significant benefits in terms of a significant reduction in burning sensation and intensity by treated patients [36] as well as in pain induced by osteoarthritis or TMJ arthralgia compared with ibuprofen [37].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Orofacial Pain Management: An Overview of the Potential Benefits of Palmitoylethanolamide and Other Natural Agents

et al. 2023

View full text Add to dashboard Cite

Pain is the most common symptom that dentists are confronted with, whether acute (pulpitis, acute periodontitis, post-surgery, etc.) or chronic diseases, such as periodontitis, muscle pain, temporomandibular joint (TMJ) disorders, burning mouth syndrome (BMS), oral lichen planus (OLP) and others. The success of therapy depends on the reduction in and management of pain through specific drugs, hence the need to analyze new pain medications with specific activity, which are suitable for long-term use, with a low risk of side effects and interactions with other drugs, and capable of leading to a reduction in orofacial pain. Palmitoylethanolamide (PEA) is a bioactive lipid mediator, which is synthesized in all tissues of the body as a protective pro-homeostatic response to tissue damage and has aroused considerable interest in the dental field due to its anti-inflammatory, analgesic, antimicrobial, antipyretic, antiepileptic, immunomodulatory and neuroprotective activities. It has been observed that PEA could play a role in the management of the pain of orofacial origin, including BMS, OLP, periodontal disease, tongue a la carte and temporomandibular disorders (TMDs), as well as in the treatment of postoperative pain. However, actual clinical data on the use of PEA in the clinical management of patients with orofacial pain are still lacking. Therefore, the main objective of the present study is to provide an overview of orofacial pain in its many manifestations and an updated analysis of the molecular pain-relieving and anti-inflammatory properties of PEA to understand its beneficial effects in the management of patients with orofacial pain, both neuropathic and nociceptive in nature. The aim is also to direct research toward the testing and use of other natural agents that have already been shown to have anti-inflammatory, antioxidant and pain-relieving actions and could offer important support in the treatment of orofacial pain.

show abstract

“…Rankin et al [5] evaluated the effects of N-acylethanolamines (NAEs), a family of endogenous biologically active lipid mediators, with palmitoylethanolamide (PEA), which have anti-inflammatory and analgesic properties, on oral mucosa biopsies from oral lichen planus (OLP) patients, a chronic inflammatory oromucosal disease. The authors concluded that there is an imbalance between prostaglandins and PEA in OLP, opening up the possibility that PEA might be a useful treatment for this oral disorder.…”

mentioning

confidence: 99%

Models for Oral Biology Research

2022

View full text Add to dashboard Cite

show abstract

Relative Deficiency of Anti-Inflammatory N-Acylethanolamines Compared to Prostaglandins in Oral Lichen Planus

Cited by 4 publications

References 45 publications

Feline Chronic Gingivostomatitis Diagnosis and Treatment through Transcriptomic Insights

Feline Chronic Gingivostomatitis Diagnosis and Treatment through Transcriptomic Insights

Orofacial Pain Management: An Overview of the Potential Benefits of Palmitoylethanolamide and Other Natural Agents

Models for Oral Biology Research

Contact Info

Product

Resources

About