Relative effects of exercise training and alendronate treatment on skeletal muscle function of ovariectomized rats

Widrick, Jeffrey J.; Fuchs, Robyn K.; Maddalozzo, Gianni F.; Marley, Kevin; Snow, Christine M.

doi:10.1097/01.gme.0000227861.35226.fa

Cited by 16 publications

(14 citation statements)

References 35 publications

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“…Total protein content and muscle weight were greater for the Run mice. These findings are consistent with other reports of soleus muscle hypertrophy in response to wheel running by rodents (38,39).…”

Section: Discussionsupporting

confidence: 95%

“…First, its strength is known to be manipulated by both E2 (26) and run training (38). Second, it is the most metabolically active muscle in the lower leg during rest and up to moderate-speed locomotion in rodents (21), and thus one would presume that its functional capacity would normally be matched to that of the adjacent tibial bone.…”

Section: Determination Of Soleus Muscle In Vitro Contractility and Tomentioning

confidence: 99%

See 1 more Smart Citation

Voluntary run training but not estradiol deficiency alters the tibial bone-soleus muscle functional relationship in mice

Warren¹,

Moran

Hogan³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

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The study's objective was to investigate how estrogen deficiency and run training affect the tibial bone-soleus muscle functional relationship in mice. Female mice were assigned into one of two surgical conditions, ovariectomy (OVX) or sham ovariectomy (sham), and one of two activity conditions, voluntary wheel running (Run) or sedentary (Sed). To determine whether differences observed between OVX and sham conditions could be attributed to estradiol (E(2)), additional OVX mice were supplemented with E(2). Tibial bones were analyzed for their functional capacities, ultimate load, and stiffness. Soleus muscles were analyzed for their functional capacities, maximal isometric tetanic force (P(o)), and peak eccentric force. The ratios of bone functional capacities to those of muscle were calculated. The bone functional capacities were affected by both surgical condition and activity but more strongly by surgical condition. Ultimate load and stiffness for the sham group were 7-12% greater than those for OVX animals (P = 0.002), whereas only stiffness was greater for Run than for Sed animals (9%; P = 0.015). The muscle functional capacities were affected by both surgical condition and activity; however, in contrast to the bone, the muscle was more affected by activity. P(o) and peak eccentric force were 10-21% greater for Run than for Sed animals (P < or = 0.016), whereas only P(o) was greater in sham than in OVX animals (9%; P = 0.011). The bone-to-muscle ratios of functional capacities were affected by activity but not by surgical condition or E(2) supplementation. Thus a mismatch of bone-muscle function occurred in mice that voluntarily ran on wheels, irrespective of estrogen status.

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Section: Discussionsupporting

confidence: 95%

Section: Determination Of Soleus Muscle In Vitro Contractility and Tomentioning

confidence: 99%

Voluntary run training but not estradiol deficiency alters the tibial bone-soleus muscle functional relationship in mice

Warren¹,

Moran

Hogan³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

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“…The muscles were mounted between an isometric force transducer and an immovable post via the tendons, and suspended in a temperature-controlled (22 °C) bicarbonate buffer that was continuously bubbled with 95% O 2 and 5% CO 2 27. Supramaximal stimuli (200 μs pulses at 60 Hz for SOL and 120 Hz for EDL) were delivered to platinum electrodes flanking the muscle.…”

Section: Methodsmentioning

confidence: 99%

Whole-body vibration slows the acquisition of fat in mature female rats

et al. 2008

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Objective: To evaluate the effects of whole-body vibration on fat, bone, leptin and muscle mass. Methods/Design: Thirty 7-month-old female 344 Fischer rats were randomized by weight into three groups (baseline, vibration or control; n ¼ 8-10 per group). Rats in the vibration group were placed inside individual compartments attached to a Pneu-Vibe vibration platform (Pneumex, Sandpoint, ID, USA) and vibrated at 30-50 Hz (6 mm peak to peak) for 30 min per day, 5 days per week, for 12 weeks. The vibration intervention consisted of six 5-min cycles with a 1-min break between cycles. Results: There were significant body composition differences between the whole-body vibration and the control group. The whole-body vibration group weighed approximately 10% less (mean ± s.d.; 207 ± 10 vs 222 ± 15 g, Po0.03) and had less body fat (20.8 ± 3.8 vs 26.8 ± 5.9 g, Po0.05), a lower percentage of body fat (10.2 ± 1.7 vs 12 ± 2.0%, Po0.05), and lower serum leptin levels (1.06 ± 0.45 vs 2.27 ± 0.57 ng ml À1 , Po0.01) than the age-matched controls. No differences were observed for total lean mass, bone mineral content (BMC), bone mineral density (BMD), insulin-like growth factor-I (IGF-I) or soleus (SOL) and extensor digitorum longus (EDL) mass or function. Regional high-resolution dual-energy X-ray absoptiometry scans of the lumbar spine (L1-4) revealed that the whole-body vibration group had significantly greater BMC (0.33 ± 0.05 vs 0.26 ± 0.03 g, Po0.01) and BMD (0.21±0.01 vs 0.19±0.01 g cm À2 , Po0.01) than the control group. No differences between the groups were observed in the amount of food consumed. Conclusion: These findings show that whole-body vibration reduced body fat accumulation and serum leptin without affecting whole body BMC, BMD or lean mass. However, the increase in vertebral BMC and BMD suggests that vibration may have resulted in local increases in bone mass and density. Also, whole-body vibration did not affect muscle function or food consumption.

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“…Pharmacological studies using both anti-catabolic and anabolic agents demonstrate that bone properties can be impacted independent of muscle changes [56, 57]. Similarly, studies introducing external loading to anesthetized animals demonstrate bone hypertrophy that is independent of muscle [58].…”

Section: Muscle Forces On Bone During Locomotionmentioning

confidence: 99%

Biomechanical Aspects of the Muscle-Bone Interaction

Avin

Bloomfield

Gross

et al. 2014

Curr Osteoporos Rep

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There is growing interest in the interaction between skeletal muscle and bone, particularly at the genetic and molecular levels. However, the genetic and molecular linkages between muscle and bone are achieved only within the context of the essential mechanical coupling of the tissues. This biomechanical and physiological linkage is readily evident as muscles attach to bone and induce exposure to varied mechanical stimuli via functional activity. The responsiveness of bone cells to mechanical stimuli, or their absence, is well established. However, questions remain regarding how muscle forces applied to bone serve to modulate bone homeostasis and adaptation. Similarly, the contributions of varied, but unique, stimuli generated by muscle to bone (such as low-magnitude, high-frequency stimuli) remains to be established. The current article focuses upon the mechanical relationship between muscle and bone. In doing so, we explore the stimuli that muscle imparts upon bone, models that enable investigation of this relationship, and recent data generated by these models.

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Relative effects of exercise training and alendronate treatment on skeletal muscle function of ovariectomized rats

Cited by 16 publications

References 35 publications

Voluntary run training but not estradiol deficiency alters the tibial bone-soleus muscle functional relationship in mice

Voluntary run training but not estradiol deficiency alters the tibial bone-soleus muscle functional relationship in mice

Whole-body vibration slows the acquisition of fat in mature female rats

Biomechanical Aspects of the Muscle-Bone Interaction

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