Relative importance of abnormalities of CCK and 5‐HT (serotonin) in <i>Giardia</i>‐induced post‐infectious irritable bowel syndrome and functional dyspepsia

Dizdar, Vernesa; Spiller, Robin C.; Singh, Gulzar; Hanevik, Kurt; Gilja, Odd Helge; Hausken, Trygve

doi:10.1111/j.1365-2036.2010.04251.x

Cited by 90 publications

(66 citation statements)

References 43 publications

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“…Several abnormalities in the density of gut endocrine cells have been described in both sporadic and postinfectious IBS patients (Tables 1.1 and 1.2) [55,[118][119][120][121][122][123][124][125][126][127][128][129][130][131][132]. It is noteworthy that the abnormalities observed are structural and not merely changes in hormone concentration.…”

Section: Abnormalities In Gut Endocrine Cells In Patients With Irritamentioning

confidence: 84%

Diet and Irritable Bowel Syndrome, with a Focus on Appetite-Regulating Gut Hormones

Gundersen¹,

Hatlebakk

Hausken

2014

Nutrition in the Prevention and Treatment of Abdominal Obesity

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Section: Abnormalities In Gut Endocrine Cells In Patients With Irritamentioning

confidence: 84%

Diet and Irritable Bowel Syndrome, with a Focus on Appetite-Regulating Gut Hormones

Gundersen¹,

Hatlebakk

Hausken

2014

Nutrition in the Prevention and Treatment of Abdominal Obesity

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“…The other endocrine cell types are not affected, including serotonin cells (52). In post infectious IBS, however, the number of CCK and serotonin cells has been reported to be increased (112).…”

Section: The Neuroendocrine System (Nes) Of the Gutmentioning

confidence: 91%

The role of diet in the pathogenesis and management of irritable bowel syndrome (Review)

El‐Salhy

Østgaard

Gundersen³

et al. 2012

Int J Mol Med

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Abstract. Most patients with irritable bowel syndrome (IBS) believe that diet plays a significant role in inducing IBS symptoms and desire to know what foods to avoid. It has been found that the intake of calories, carbohydrates, proteins and fat by IBS patients does not differ from that of the background population. IBS patients were found to avoid certain food items that are rich in fermentable oligo-, di-and monosacharides and polyols (FODMAPs), but they did have a high consumption of many other FODMAP-rich food items. The diet of IBS patients was found to consist of a low calcium, magnesium, phosphorus, vitamin B2 and vitamin A content. There is no consistent evidence that IBS patients suffer from food allergy, nor is there documented evidence that food intolerance plays a role in IBS symptoms. Abnormalities in gut hormones have been reported in IBS patients. As gut hormones control and regulate gastrointestinal motility and sensation, this may explain the abnormal gastrointestinal motility and visceral hypersensitivity reported in these patients. Guidance concerning food management which includes individually based restrictions of FODMAP-rich food items and individual evaluation of the effects of protein-, fat-and carbohydrate-rich/poor diets may reduce IBS symptoms.

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“…For instance, mucosal cellular changes (enterochromaffin cells hyperplasia) [14], abnormal intestinal permeability and cytokine increase [15] have been reported in PI-IBS related to Campylobacter species; abnormalities of immunoendocrine cells [16] have been described in PI-IBS related to Shigella infection; and mucosal cellular changes (enterochromaffin cells decrease and cholecystokinin-containing cell increase) [17] and visceral hypersensitivity [18] have been documented in Giardia infested patients.…”

Section: Pathophysiologic Aspectsmentioning

confidence: 99%

Clostridium difficile-related postinfectious IBS: a case of enteroglial microbiological stalking and/or the solution of a conundrum?

Bassotti

Macchioni

Corazzi

et al. 2017

Cell. Mol. Life Sci.

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Post-infectious irritable bowel syndrome is a well-defined pathological entity that develops in about one-third of subjects after an acute infection (bacterial, viral) or parasitic infestation. Only recently it has been documented that an high incidence of post-infectious irritable bowel syndrome occurs after Clostridium difficile infection. However, until now it is not known why in some patients recovered from this infection the gastrointestinal disturbances persist for months or years. Based on our in vitro studies on enteric glial cells exposed to the effects of C. difficile toxin B, we hypothesize that persistence of symptoms up to the development of irritable bowel syndrome might be due to a disturbance/impairment of the correct functions of the enteroglial intestinal network.

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Relative importance of abnormalities of CCK and 5‐HT (serotonin) in Giardia‐induced post‐infectious irritable bowel syndrome and functional dyspepsia

Cited by 90 publications

References 43 publications

Diet and Irritable Bowel Syndrome, with a Focus on Appetite-Regulating Gut Hormones

Diet and Irritable Bowel Syndrome, with a Focus on Appetite-Regulating Gut Hormones

The role of diet in the pathogenesis and management of irritable bowel syndrome (Review)

Clostridium difficile-related postinfectious IBS: a case of enteroglial microbiological stalking and/or the solution of a conundrum?

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