Relative source contributions of diet and air to ingested asbestos exposure.

Rowe, James N.

doi:10.1289/ehp.8353115

Cited by 12 publications

(6 citation statements)

References 12 publications

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“…Thus, he might have ingested a large amount of asbestos fibers. Asbestos ingestion via food intake [ 44 ] or transport of the chemical to the stomach via respiration [ 45 ] has been suggested to cause gastric cancer. It has also been reported that gastric cancer development associated with chrysotile is more frequent than that with crocidolite [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Risk assessment of gastric cancer associated with asbestosis: a case report

Park¹,

Kang²,

Koo³

et al. 2015

Ann of Occup and Environ Med

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BackgroundThe International Agency for Research on Cancer classifies asbestos as belonging to Carcinogen Group 2A for gastric cancer. We herein report a case of gastric cancer associated with asbestosis and describe the work-related and risk assessments of asbestos exposure for gastric cancer.Case presentationThe 66-year-old male patient in our case worked in asbestos spinning factories. His level of cumulated asbestos fiber exposure was estimated to be 38.0–71.0 f-yr/cc. Thus, the Excess Life Cancer Risk for lung cancer associated with asbestos exposure was 9,648×10−5, almost 9,600 times the value recommended by the United States of America Environmental Protection Agency (1 × 10−5). The relative risk of developing lung cancer for this patient was more than 25 f-yr/cc, a well-known criterion for doubling the risk of lung cancer.ConclusionThe patient’s exposure to high-dose asbestos was sufficient to increase his risk of gastric cancer because as the risk of lung cancer increased, the risk of gastric cancer was due to increase as well. Therefore, occupational asbestos fiber exposure might be associated with gastric cancer in this case.

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Section: Discussionmentioning

confidence: 99%

Risk assessment of gastric cancer associated with asbestosis: a case report

Park¹,

Kang²,

Koo³

et al. 2015

Ann of Occup and Environ Med

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“…Asbestos fiber from cement pipelines results in an average of 1 μm fiber pieces due to natural erosion [38]. Furthermore, diet supplies (food, beverages, and orally administered drugs) contaminated by asbestos in water or airborne must also be considered as a possible source to GI cancer [39]. …”

Section: Epidemiological Evidence: Gastrointestinal Cancers With Asbementioning

confidence: 99%

Asbestos-Induced Gastrointestinal Cancer: An Update

Kim

Williams

Cheresh

et al. 2013

J Gastrointest Dig Syst

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Asbestos-related diseases, such as malignancies and asbestosis, remain a significant occupational and public health concern. Asbestos is still widely used in many developing countries despite being a recognized carcinogen that has been banned over 50 countries. The prevalence and mortality from asbestos-related diseases continue to pose challenges worldwide. Many countries are now experiencing an epidemic of asbestos-related disease that is the legacy of occupational exposure during the 20th century because of the long latency period (up to 40 years) between initial asbestos exposure and exhibition of disease. However, the gastrointestinal (GI) cancers resulting from asbestos exposure are not as clearly defined. In this review, we summarize some of the recent epidemiology of asbestos-related diseases and then focus on the evidence implicating asbestos in causing GI malignancies. We also briefly review the important new pathogenic information that has emerged over the past several years that may account for asbestos-related gastrointestinal cancers. All types of asbestos fibers have been implicated in the mortality and morbidity from GI malignancies but the collective evidence to date is mixed. Although the molecular basis of GI cancers arising from asbestos exposure is unclear, there have been significant advances in our understanding of mesothelioma and asbestosis that may contribute to the pathophysiology underlying asbestos-induced GI cancers. The emerging new evidence into the pathogenesis of asbestos toxicity is providing insights into the molecular basis for developing novel therapeutic strategies for asbestos-related diseases in future management.

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“…“Unknown” exposures indicate the data came from occupational exposure matrices, including textiles, insulation, or cement workers. Sources: a Haque, 1992; 1996; 1998; Tsurikova, 1992. b Haque, 2001. c Schneider, 1977. d Saat, 1980; Dopp, 1997; Stevens, 1983. e Germani, 1999; Langseth, 2004; Magnani, 2008; Pira, 2005; Reid, 2009; Acheson, 1982; Newhouse, 1985; Wignall, 1982; Berry, 2000. f Millette, 1983. g Graham, 1967. h Attanoos, 2000. i Polissar, 1982.…”

Section: Reproductive and Developemental Effects Of Asbestosmentioning

confidence: 99%

“…However, a cell-mediated immunity towards primary rat fetal cells from rats with Canadian chrysotile B fiber-induced mesothelioma was observed ( Stevens et al, 1983 ), suggesting a link between fetal death and the immune system. In addition, a decrease in surface labeling of glycolipids and glycoproteins in hamster embryos treated with chrysotile asbestos was noted ( Saat et al, 1980 ), along with a rise in micronucleated human amniotic cells ( Dopp et al, 1997 ). Furthermore, incubation of rat embryo cells with crocidolite for 2–48 h resulted in an increase in DNA strand breakage within 2–6 h ( Libbus et al, 1989 ).…”

Section: Reproductive and Developemental Effects Of Asbestosmentioning

confidence: 99%

Nonpulmonary Outcomes of Asbestos Exposure

Bunderson-Schelvan

Pfau

Crouch

et al. 2011

Journal of Toxicology and Environmental Health, Part B

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The adverse pulmonary effects of asbestos are well accepted in scientific circles. However, the extrapulmonary consequences of asbestos exposure are not as clearly defined. In this review the potential for asbestos to produce diseases of the peritoneum, immune, gastrointestinal (GIT), and reproductive systems are explored as evidenced in published, peer-reviewed literature. Several hundred epidemiological, in vivo, and in vitro publications analyzing the extrapulmonary effects of asbestos were used as sources to arrive at the conclusions and to establish areas needing further study. In order to be considered, each study had to monitor extrapulmonary outcomes following exposure to asbestos. The literature supports a strong association between asbestos exposure and peritoneal neoplasms. Correlations between asbestos exposure and immune-related disease are less conclusive; nevertheless, it was concluded from the combined autoimmune studies that there is a possibility for a higher-than-expected risk of systemic autoimmune disease among asbestos-exposed populations. In general, the GIT effects of asbestos exposure appear to be minimal, with the most likely outcome being development of stomach cancer. However, IARC recently concluded the evidence to support asbestos-induced stomach cancer to be “limited.” The strongest evidence for reproductive disease due to asbestos is in regard to ovarian cancer. Unfortunately, effects on fertility and the developing fetus are under-studied. The possibility of other asbestos-induced health effects does exist. These include brain-related tumors, blood disorders due to the mutagenic and hemolytic properties of asbestos, and peritoneal fibrosis. It is clear from the literature that the adverse properties of asbestos are not confined to the pulmonary system.

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Relative source contributions of diet and air to ingested asbestos exposure.

Cited by 12 publications

References 12 publications

Risk assessment of gastric cancer associated with asbestosis: a case report

Risk assessment of gastric cancer associated with asbestosis: a case report

Asbestos-Induced Gastrointestinal Cancer: An Update

Nonpulmonary Outcomes of Asbestos Exposure

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