Relative Susceptibilities of ABO Blood Groups to<i>Plasmodium falciparum</i>Malaria in Ghana

Afoakwah, Richmond; Aubyn, Edmond; Prah, James Kojo; Nwaefuna, Ekene K.; Boampong, Johnson Nyarko

doi:10.1155/2016/5368793

Cited by 22 publications

(18 citation statements)

References 33 publications

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“…Notwithstanding the foregoing, the mean parasitemia in blood recipients of blood group O was less than that in recipients of group A (2068 vs. 3859 parasites/µL of blood). This confirms that blood group A is very susceptible to P. falciparum infection than blood group O (Panda et al 2011 ; Afoakwah et al 2016 ).…”

Section: Discussionsupporting

confidence: 63%

“…Similarly, it has also been established that anemia, especially iron deficiency anemia, increases susceptibility to infectious diseases (Beard 2001 ). Individuals with blood groups A and B were found to be highly susceptible to P. falciparum infection in several studies (Panda et al 2011 ; Afoakwah et al 2016 ). However, in this study, the frequency of incidence of P. falciparum infection was found to be high in blood group O.…”

Section: Discussionmentioning

confidence: 99%

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Immunochromatographic and microscopic detection of Plasmodium falciparum in recipients of P. falciparum-infected donor blood

et al. 2022

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Blood transfusion practice is an essential medical intervention; however, it poses problems of transmissibility of infectious diseases including malaria. This study was designed to determine the potential of transfusion-transmitted malaria (TTM) by detecting malaria antigens and parasites in recipients of infected donor blood. After successful blood transfusion, remnants of transfused blood were screened for Plasmodium falciparum HRP2 antigen and parasitemia using CareStart malaria RDT and 10% Giemsa stain microscopy respectively according to established protocols. Recipients of microscopy detectable P. falciparum in infected blood who tested negative for malaria by both microscopy and mRDT prior to receiving infected donor blood were followed up weekly for 35 days. Donor P. falciparum antigenemia and parasitemia were 12.1% and 8.4%, respectively, while the prevalence of blood recipient parasitemia was 3.2%. Blood stored for 2–5 days recorded mean parasitemia higher than those stored for a day and after 5 days. Additionally, parasitemia was observed in all follow-up days with marginally high frequencies in days 7, 14, and 35. There was no association between the attributes (storage days, blood group, and parasite count range) of the infected donor blood units and the characteristics of blood recipients with post-transfusion parasitemia. This study provides baseline data on TTM in Ghana. However, further studies should establish the genetic relatedness of the implicated parasites since new infections and/or recrudescence of previous infections could account for this observation.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Immunochromatographic and microscopic detection of Plasmodium falciparum in recipients of P. falciparum-infected donor blood

et al. 2022

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“…Hence, the incidence of this blood group is very high in tropical regions of the world where infectious diseases are common [ 55 ]. The clinical importance of this distribution is illuminated by the low malaria parasitemia seen in individuals with the blood group O who live in West Africa [ 15 ].…”

Section: Resultsmentioning

confidence: 99%

“…However, it has yet to be fully established the validity or otherwise of how the statistical associations between blood group and some disease risks actually translate in vivo; evidence suggests that blood group antigens may play a biological role in some disease pathogenesis [ 7 ]. ABO antigen type has been postulated from many reports as a risk factor for some cardiovascular diseases [ 8 – 10 ], cancers [ 11 – 14 ], and infectious diseases [ 15 – 17 ]. The proposed mechanism believed to underlie how ABO blood group may influence cardiovascular disease risk involves the possible regulatory effect of ABO antigens on plasma levels of von Willebrand factor (VWF) and coagulation factor VIII (FVIII) [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Association of ABO Blood Group and Body Mass Index: A Cross-Sectional Study from a Ghanaian Population

Smith

Okai

Abaidoo

et al. 2018

Journal of Nutrition and Metabolism

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ABO blood group and body mass index (BMI) have individually been appraised as risk factors for certain diseases. From statistical perspective, it may be important to examine the relationship between the ABO blood antigen and BMI. This cross-sectional study involved 412 participants aged 18 to 46 at the Kwame Nkrumah University of Science and Technology (KNUST), Kumasi. Weight and height of participants were measured for BMI calculation; blood group determination was done using antisera. Blood group O was the most prevalent (51.2%), while Rhesus-positive individuals constituted 90.3%. 6.3% of the participants were obese, while 18.7% were overweight. There was significant (p=0.006) higher prevalence of obesity in females (10.3%) than in males (3.4%). The study did not observe any significant difference by association of ABO blood group with gender (p=0.973), BMI (p=0.307), or Rhesus status (p=0.723). Regarding gender (p=0.400) and BMI (p=0.197), no statistically significant difference was observed between Rhesus blood groups. The prevalence of overweight, obesity, blood type O, and rhesus positive observed among students in this study is largely similar to what has been reported in published studies in Ghana and from other countries. Overweight and obesity were not associated with ABO blood groups or Rhesus in this study.

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“…[ 37 ] and Afoakwah et al. [ 38 ], who recorded higher malaria prevalence for blood group O in Ghana. Another study suggested that the ABO blood group does not hinder the development of uncomplicated falciparum malaria but severe malaria [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

A cross-sectional study of the prevalence, density, and risk factors associated with malaria transmission in urban communities of Ibadan, Southwestern Nigeria

Awosolu

Yahaya

Termizi

et al. 2021

Heliyon

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Background: Malaria is a severe global public health challenge that causes significant morbidity and mortality worldwide, particularly in sub-Saharan Africa. This study was designed to determine the prevalence, parasite density, and risk factors associated with malaria infection transmission among residents of two urban communities of Ibadan, southwestern Nigeria. Materials and methods: A cross-sectional hospital-based study was carried out on 300 participants. Blood samples were obtained. Thick and thin blood films were prepared and viewed using the standard parasitological technique of microscopy. Moreover, data on sociodemographic and environmental variables were obtained using a pretested standard questionnaire. Results: Of the 300 participants examined, a total of 165 (55.0%) were found positive for Plasmodium falciparum with a mean (S.D) parasite density of 1814.70 (1829.117) parasite/μL of blood. The prevalence and parasite density of malaria infection vary significantly (P < 0.05) with age group. Children <5 years old were more likely to have malaria infection and high parasite densities than adults (p < 0.05). Similarly, in relation to gender, males significantly (P < 0.05) had a higher prevalence (60.2%) and mean (S.D) parasite density of malaria infection [2157.73 (1659.570) parasite/μL of blood] compared to females. Additionally, those without formal education had the highest prevalence (73.0%) and mean (S.D) parasite density of infection [2626.96 (2442.195) parasite/μL of blood]. The bivariate logistic regression analysis shows that age group 6-10 (Crude Odds Ratio, COR 0.066, 95% CI: 0.007-0.635), presence of streams/rivers (COR 0.225, 95% CI: 0.103-0.492), distance from streams/ rivers within 1 km (COR 0.283, 95% CI: 0.122-0.654) and travel to rural area (COR 4.689, 95% CI: 2.430-9.049) were the significant risk factors. Conclusions: Malaria infection is prevalent in the study area and was greatly influenced by traveling activities from the rural areas to urban centers and vice versa. Multifaceted and integrated control strategy should be adopted. Health education on mosquito prevention and chemoprophylaxis before and during travel to rural areas are essential.

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Relative Susceptibilities of ABO Blood Groups toPlasmodium falciparumMalaria in Ghana

Cited by 22 publications

References 33 publications

Immunochromatographic and microscopic detection of Plasmodium falciparum in recipients of P. falciparum-infected donor blood

Immunochromatographic and microscopic detection of Plasmodium falciparum in recipients of P. falciparum-infected donor blood

Association of ABO Blood Group and Body Mass Index: A Cross-Sectional Study from a Ghanaian Population

A cross-sectional study of the prevalence, density, and risk factors associated with malaria transmission in urban communities of Ibadan, Southwestern Nigeria

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