Relaxant effects of the essential oil of Ocimum gratissimum on isolated ileum of the guinea pig

Madeira, Socorro Vanesca Frota; Matos, F. J. A.; Leal-Cardoso, José Henrique; Criddle, David N.

doi:10.1016/s0378-8741(02)00049-1

Cited by 56 publications

(35 citation statements)

References 8 publications

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“…Also, Chromolaena odorata, Nicotiana tabacum, Ocimum gratissimum and Xylopia aethiopica, each had the UMi of 0.167. These plants have been cited in many herbal remedies [69][70][71][72][73]. Vernonia was the only genus in which two species; V. amygdalina (UMi 0.125) and V. cinerea (UMi 0.042) was encountered in the survey.…”

Section: Resultsmentioning

confidence: 99%

Ethno-medicines for Mosquito Transmitted Diseases from South-western Nigeria

Sonibare¹,

Okorie²,

Aremu³

et al. 2015

JNR

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Ipomoea reniformis Chaos is claimed in Indian traditional medical practice to be useful in the treatment of epilepsy and neurological disorders. In the present study, pretreatment effect of methanolic extract of Ipomoea reniformis on epilepsy and psychosis was evaluated in rodents using standard procedures. Besides evaluating epileptic and behavioral parameters, neurotransmitters such as Gamma-Amino Butyric Acid (GABA) in epilepsy and in psychosis dopamine, noradrenaline and serotonin contents in the rodent brain were estimated. The extract pretreatment reduced maximal electro shock; Isoniazid (INH) and Pentylenetetrazole (PTZ) induced seizures and also significantly inhibited the attenuation of brain GABA levels by INH and PTZ in mice. These results suggested that the observed beneficial effect in epilepsy may be by enhancing the GABAergic system. The test drug also inhibited the apomorphine induced climbing and stereotyped behavior and showed significantly reduced levels of brain dopamine, noradrenaline and serotonin which may be due to blocking of central dopaminergic, noradrenergic and serotonergic pathways or by enhancing the GABAergic system. The results obtained in present study suggest that the title plant possesses antiepileptic and antipsychotic activities in rodents.

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Section: Resultsmentioning

confidence: 99%

Ethno-medicines for Mosquito Transmitted Diseases from South-western Nigeria

Sonibare¹,

Okorie²,

Aremu³

et al. 2015

JNR

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“…However, research trials that show consistent benefi cial effects in pigs are limited. 14,15 Why the inconsistent results in research on probiotics and prebiotics?…”

Section: What Are Probiotics?mentioning

confidence: 99%

“…Phytogenic substances from certain herbs, spices, and their extracts have also been shown to have pharmacologic actions within the digestive tract, as evidenced by their relaxant and spasmolytic effects. [14][15][16] Anti-oxidative effects. Anti-oxidative properties of some phytogenic substances have been attributed to the phenolic terpenes in the essential oils.…”

Section: What Products Are Being Used As Phytogenic Feed Additives?mentioning

confidence: 99%

Feed additives for swine: Fact sheets – prebiotics and probiotics, and phytogenics (2010)

Jacela¹,

DeRouchey²,

Tokach³

et al. 2010

Kansas Agricultural Experiment Station Research Reports

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“…Earlier reports have also shown the smooth muscle contracting and antimutagenic activity [62] as well as its anti-diarrhoeal effects in experimental animals [63], high antiviral indices against HIV-1 and HIV-2 [64]; shigellocidal properties [65,66], anti-trypanosomal effects [67], immunobiologicalactivity [68], gastroprotective properties [69], controlling agent for food spoilage and mycotoxin producing fungi [70], disintegrant properties of its seed mucilage [71], and as a relaxant on isolated ileum from guinea pig [72]. Its essential oil has mosquito repellant, insecticidal properties [73,74].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Constituents and Antimicrobial and Grain Protectant Activities of Clove Basil (Ocimum gratissimum L.) Grown in Nigeria

Mann¹

2012

PLANT

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Ocimum gratissimum Linn (Lamiaceae) is an herbaceous plant reputed for many medicinal and agronomic practices amongst Nigerian peasant farmers. O. gratissimum was investigated for antimicrobial activity against ten micro-organisms and for grain protectant activity against Callosobrochus maculatus. The phytocontituents of the aerial part of O. gratissimum were extracted with 95% ethanol using the percolation method. The crude ethanol extracted was further fractionated into hexane, chloroform and methanol fractions. The fractions obtained were screened for phytoconstiteunts, antimicrobial and grain protectant properties. Result showed that hexane fraction exhibited the highest antimicrobial activity against Vibrio cholera and Klebsiella pneumonia. Similarly hexane fraction also showed the highest grain protectant activity. The other extracts of the O. gratissimum did not significantly inhibit both bacterial growth and grain infestation. However, the methanol fraction contains phytocompounds such as phenolic compounds associated with antioxidant properties. The study shows that O. gratissimum extractants are potential sources of antimicrobial and preservative agents.

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Relaxant effects of the essential oil of Ocimum gratissimum on isolated ileum of the guinea pig

Cited by 56 publications

References 8 publications

Ethno-medicines for Mosquito Transmitted Diseases from South-western Nigeria

Ethno-medicines for Mosquito Transmitted Diseases from South-western Nigeria

Feed additives for swine: Fact sheets – prebiotics and probiotics, and phytogenics (2010)

Phytochemical Constituents and Antimicrobial and Grain Protectant Activities of Clove Basil (Ocimum gratissimum L.) Grown in Nigeria

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