Release and antibacterial activity of allyl isothiocyanate/β-cyclodextrin complex encapsulated in electrospun nanofibers

Abstract

a b s t r a c tAllyl isothiocyanate (AITC) is known as an efficient antibacterial agent but it has a very high volatility. Herein, AITC and AITC/␤-cyclodextrin (CD)-inclusion complex (IC) incorporated in polyvinyl alcohol (PVA) nanofibers were produced via electrospinning. SEM images elucidated that incorporation of AITC and AITC/␤-CD-IC into polymer matrix did not affect the bead-free fiber morphology of PVA nanofibers. 1 H-NMR and headspace GC-MS analyses revealed that very low amount of AITC was remained in PVA/AITC-NF because of the rapid evaporation of AITC during the electrospinning process. Nevertheless, much higher amount of AITC was preserved in the PVA/AITC/␤-CD-IC-NF due to the CD inclusion complexation. The sustained release of AITC from nanofibers was evaluated at 30 • C, 50 • C and 75 • C via headspace GC-MS. When compared to PVA/AITC-NF, PVA/AITC/␤-CD-IC-NF has shown higher antibacterial activity against Escherichia coli and Staphylococcus aureus due to the presence of higher amount of AITC in this sample which was preserved by CD-IC.

Quercetin/β-cyclodextrin inclusion complex embedded nanofibres: Slow release and high solubility

“…Incorporation of QU/b-CD-IC into electrospun nanofibres could be a valuable approach to use QU in a more efficient way, because of the high surface area-tovolume ratio and highly porous structure of nanofibres. Related studies on CD-IC incorporated electrospun nanofibres for different purposes have already been reported by our group (Aytac, Dogan, Tekinay, & Uyar, 2014;Aytac, Sen, Durgun, & Uyar, 2015;Canbolat, Celebioglu, & Uyar, 2014;Celebioglu, Umu, Tekinay, & Uyar, 2014;Kayaci, Ertas, & Uyar, 2013;Kayaci, Sen, Durgun, & Uyar, 2014;Kayaci, Umu, Tekinay, & Uyar, 2013;Kayaci & Uyar, 2012). CDs were also used for crosslinking of polymeric materials (Li & Hsieh, 2005;Liu, Zhang, Liu, Ni, & Li, 2013).…”

Electrospinning of cyclodextrin/linalool-inclusion complex nanofibers: Fast-dissolving nanofibrous web with prolonged release and antibacterial activity

“…In addition, CDs have distinct advantages over many molecules, since they can form host-guest ICs with a variety of compounds. The production of CD-IC incorporated polymeric nanofibers has been previously reported by our group (Aytac, Dogan, Tekinay, & Uyar, 2014;Aytac, Kusku, Durgun, & Uyar, 2016a,b;Aytac, Sen, Durgun, & Uyar, 2015;Kayaci, Sen, Durgun, & Uyar, 2014;Kayaci & Uyar, 2012;Uyar, Nur, Hacaloglu, & Besenbacher, 2009. However, organic solvents have been used in most of these studies in order to dissolve the polymeric matrix for the preparation of solution for electrospinning.…”

Antibacterial electrospun zein nanofibrous web encapsulating thymol/cyclodextrin-inclusion complex for food packaging

“…Hence, electrospun nanofibers have the potential to be used in food packaging applications (Vega-Lugo & Lim, 2009;Wen, Zhu, Feng et al, 2016;. Moreover, CD-ICs of various compounds including food additives, essential oils, antioxidant and antibacterial agents might be incorporated into electrospun nanofibers for enhancing solubility and thermal stability, controlling release and prolonging shelf life Aytac, Dogan, Tekinay, & Uyar, 2014;Aytac, Kusku, Durgun, & Uyar, 2016a, 2016bAytac, Sen, Durgun, & Uyar, 2015;Kayaci & Uyar, 2012;Uyar, Hacaloglu, & Besenbacher, 2011;Uyar, Nur, Hacaloglu, & Besenbacher, 2009).…”