Release Behavior of 5-Fluorouracil from Chitosan-Gel Nanospheres Immobilizing 5-Fluorouracil Coated with Polysaccharides and Their Cell Specific Cytotoxicity

Ohya, Yusuke; Shiratani, Masahiro; Kobayashi, Hironao; Ouchi, Tatsuro

doi:10.1080/10601329409349743

Cited by 135 publications

(36 citation statements)

References 19 publications

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“…By removal of excess of lactic acid and Na 2 SO 4 , particle agglutination can be sufficiently suppressed. Probably a stable dispersion state in water can be attributed to crosslinking effect between amino groups of chitosan and sulfate anion from Na 2 SO 4 .…”

Section: Discussionmentioning

confidence: 99%

“…The non-toxic, biocompatible and biodegradable properties of chitosan provide potential for many types of applications [2][3][4]. Chitosan and derivatives have become useful polysaccharides in the biomedical field.…”

Section: Introductionmentioning

confidence: 99%

“…Chitosan is a cationic biopolymer obtained from Ndeacetylation of chitin, β- (1,4 [1]. The non-toxic, biocompatible and biodegradable properties of chitosan provide potential for many types of applications [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

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Chitosan Sub-micron Particles Prepared Using Sulfate Ion Salt as Bacteriostatic Materials in Neutral pH Condition

Saita¹,

Nagaoka²,

Horikawa³

et al. 2011

JBNB

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chitosan Sub-micron Particles Prepared Using Sulfate Ion Salt as Bacteriostatic Materials in Neutral pH Condition

Saita¹,

Nagaoka²,

Horikawa³

et al. 2011

JBNB

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show abstract

“…Chitosan nanocarrier can encapsulate a variety of anticancer drugs and target the site of the tumor, and thus creates an exciting potential for cancer treatment [24,25]. For the first time in 1994, chitosan nanoparticles were prepared by Ohya et al, and the release of the 5-fluorouracil anticancer drug from this nanocarrier was investigated [26]. Chitosan nanoparticles with different particle sizes exhibit different inhibitor in tumor growth.…”

Section: Chitosan Nanoparticlementioning

confidence: 99%

A Critical Comparison Study on the pH-Sensitive Nanocomposites Based on Graphene-Grafted Chitosan for Cancer Theragnosis

Gooneh-Farahani

Naghib

Naimi‐Jamal

2019

Multidiscip Cancer Investig

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Drug delivery is one of the major issues in the world of science, which receives a large part of the research in various fields. The ultimate goal of drug delivery is to help the patient with developing advanced drug delivery systems. These systems revolutionize the treatment of many diseases including cancer. Effective drug carriers can significantly reduce the undesirable side effects of anticancer drugs through the drug controlled release and using the selective drug to cancerous tissue. The natural biocompatible and biodegradable polymer of chitosan is widely investigated in drug delivery systems, especially as the carrier for anticancer drugs. An important aspect for the application of chitosan in drug delivery for cancer treatment is its pH sensitivity. Graphene attracted much attention in various fields as a shining star in the science of materials. In recent years, the use of graphene in the diagnosis and treatment of cancer is also investigated. Therefore, chitosan-graphene nanocomposite can be introduced as a pH-sensitive carrier for cancer theragnosis. In the current study, the application of chitosan and graphene in the treatment of cancer addressed in previous years was discussed.

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“…Widespread natural polysaccharide chitosan has received increasing medical attention via encapsulating anticancer drugs such as 5-fluorouracil [ 43 ], doxorubicin [ 44 , 45 ], paclitaxel [ 46 ], cisplatin and camptothecin [ 47 ], and osthole [ 22 ]. Abundant availability, unique mucoadhesivity, inherent pharmacological properties, and other beneficial biological properties such as biocompatibility, biodegradability, low toxicity, and low immunogenicity make chitosan an exceptionally attractive NM for targeting therapeutics [ 48 , 49 ].…”

Section: Furthering Evidence On Biocompatible and Biodegradable Pomentioning

confidence: 99%

The Janus Facet of Nanomaterials

Kardos

Jemnitz

Jablonkai

et al. 2015

BioMed Research International

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Application of nanoscale materials (NMs) displays a rapidly increasing trend in electronics, optics, chemical catalysis, biotechnology, and medicine due to versatile nature of NMs and easily adjustable physical, physicochemical, and chemical properties. However, the increasing abundance of NMs also poses significant new and emerging health and environmental risks. Despite growing efforts, understanding toxicity of NMs does not seem to cope with the demand, because NMs usually act entirely different from those of conventional small molecule drugs. Currently, large-scale application of available safety assessment protocols, as well as their furthering through case-by-case practice, is advisable. We define a standard work-scheme for nanotoxicity evaluation of NMs, comprising thorough characterization of structural, physical, physicochemical, and chemical traits, followed by measuring biodistribution in live tissue and blood combined with investigation of organ-specific effects especially regarding the function of the brain and the liver. We propose a range of biochemical, cellular, and immunological processes to be explored in order to provide information on the early effects of NMs on some basic physiological functions and chemical defense mechanisms. Together, these contributions give an overview with important implications for the understanding of many aspects of nanotoxicity.

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Release Behavior of 5-Fluorouracil from Chitosan-Gel Nanospheres Immobilizing 5-Fluorouracil Coated with Polysaccharides and Their Cell Specific Cytotoxicity

Cited by 135 publications

References 19 publications

Chitosan Sub-micron Particles Prepared Using Sulfate Ion Salt as Bacteriostatic Materials in Neutral pH Condition

Chitosan Sub-micron Particles Prepared Using Sulfate Ion Salt as Bacteriostatic Materials in Neutral pH Condition

A Critical Comparison Study on the pH-Sensitive Nanocomposites Based on Graphene-Grafted Chitosan for Cancer Theragnosis

The Janus Facet of Nanomaterials

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