Release behaviour of hydrogel microparticles based on hydroxyl-ethyl-starch as a drug delivery system for proteins

Schwoerer, A.; Harling, Steffen; Menzel, Henning; Daniels, Rolf

doi:10.1016/j.jconrel.2008.09.050

Cited by 5 publications

(4 citation statements)

References 3 publications

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“…(b) Release of FITC–dextran (70 kDa) from microspheres with DS of 0.14 in human serum in comparison to sodium phosphate buffer. Reproduced with permission from ref .…”

Section: Hes-based Hydrogels As Prospective Protein Delivery Systemsmentioning

confidence: 87%

“…The so-produced spherical microparticles show a monomodal particle size distribution with an average size of about 10 μm. 47 It is evident that by increasing the network density, the release rate is decreased. It was found that small molecules are retained at a lower extent than molecules of high molecular weight (Figure 20).…”

Section: Hes-based Hydrogels As Prospectivementioning

confidence: 99%

“…The so-produced spherical microparticles show a monomodal particle size distribution with an average size of about 10 μm . It is evident that by increasing the network density, the release rate is decreased.…”

Section: Hes-based Hydrogels As Prospective Protein Delivery Systemsmentioning

confidence: 99%

“…Release of FITC–dextran of various molecular weights (20 kDa, ●○; 70 kDa, □■; 500 kDa, Δ▲) from microspheres with degree of substitution of 0.05 (open symbols) or 0.22 (filled symbols. Reproduced with permission from ref .…”

Section: Hes-based Hydrogels As Prospective Protein Delivery Systemsmentioning

confidence: 99%

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Drug Delivery Systems Based on Hydroxyethyl Starch

2017

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The advantageous biological properties of hydroxyethyl starch (HES) triggered research interest toward the design and synthesis of drug delivery systems (DDSs) based on this polysaccharide. Convenient reaction schemes, including one-step reactions, led to the synthesis of HES conjugates with selected anticancer molecules or therapeutic proteins. Nanocapsules and hydrogels based on HES were also prepared and studied as prospective drug delivery systems. Formulations originating from these drug conjugates and also from nanocapsules and hydrogels loaded with drugs were characterized, highlighting the extension of their half-life in plasma, which is a critical property as far as their efficacy is concerned. Results obtained in vitro and in vivo proved promising, justifying the undertaking of additional experiments with such systems, including their multifunctionalization. The promising formulations that are discussed in this Topical Review is expected to further increase interest in applying HES for molecular constructing novel DDSs with enhanced efficacy, which may, in the future, find clinical applications.

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“…(b) Release of FITC–dextran (70 kDa) from microspheres with DS of 0.14 in human serum in comparison to sodium phosphate buffer. Reproduced with permission from ref .…”

Section: Hes-based Hydrogels As Prospective Protein Delivery Systemsmentioning

confidence: 87%

Section: Hes-based Hydrogels As Prospectivementioning

confidence: 99%

Section: Hes-based Hydrogels As Prospective Protein Delivery Systemsmentioning

confidence: 99%

Section: Hes-based Hydrogels As Prospective Protein Delivery Systemsmentioning

confidence: 99%

See 2 more Smart Citations