Release of active and inactive renin by the porcine kidney.

Bailie, Michael D.; Derkx, F. M. H.; Schalekamp, M. A. D. H.

doi:10.1161/01.res.44.1.32

Cited by 26 publications

(16 citation statements)

References 14 publications

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“…The data on PRC in the developing rabbit differ from those observed in other species, including the rat, dog, piglet, lamb and human (2,8,14,18,21,24,25,27,28,30,33). Plasma renin concentration in the newborn rabbit was not high and was comparable to adult values.…”

Section: Discussioncontrasting

confidence: 75%

Intrarenal Distribution of Renin in the Developing Rabbit

et al. 1983

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Section: Discussioncontrasting

confidence: 75%

Intrarenal Distribution of Renin in the Developing Rabbit

et al. 1983

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“…Because the concentration of counts were present in the chromatographic fraction containing renin, the labeled material taken up by the red blood cells represented renin. big renin blood samples, 2 and 60 min after infusion on the same gel filtration columns as Figure 1. Elution occurs in the high-molecular-weight fractions.…”

Section: Resultsmentioning

confidence: 99%

“…Bailie (2) showed that the release of inactive renin from the newborn pig kidney parallels the release of active renin and found no evidence that inactive renin was converted to active renin in vivo. Our laboratory has evidence for activation of inactive plasma renin in vivo (unpublished) after infusion of exogenous inactive renin in the newborn canine puppy; and Rumpf et al (17) showed that the % of active renin in human plasma was correlated with the level of plasma kallikrein.…”

Section: Discussionmentioning

confidence: 99%

Distribution and Disappearance of Exogenous [125I] Big Renin in the Newborn Puppy

Siegel

Parkhill

1983

Pediatr Res

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Summarymodified from Inagami and Murakami (9). All buffers used in theThe distribution and metabolism of infused exogenous [lZ5II inactive plasma big renin, molecular weight 56,000, was studied in five newborn puppies. The animals were sacrificed and the organs removed and studied by chromatography, along with periodic blood samples taken during the 120-min study, for evidence of conversion of high-molecular-weight renin to low-molecular-weight renin. The decay curve suggested an initial rapid distribution (alpha) phase of 10 + 1.5 min followed by a slower elimination (beta) phase of 40 f 4.6 min. [Iz5II-Big renin was taken up by the red blood cell and released slowly. The liver, kidneys, and lungs had the highest % of [12511-big renin at the termination of the study. There was no chromatographic evidence of a change in molecular weight of the ['251j-big renin. These data show that big renin has a two-compartment disappearance curve and that there is no evidence of conversion of high-molecular-weight renin to low-molecular-weight renin systemically or in the tissues of the newborn canine puppy.

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“…Millar et al 2 * reported that inactive renin concentration showed no significant change during either sodium depletion or upright tilting in the normal subjects, but rose significantly 30 minutes after intravenous furosemide. However, Aoi et al 17 demonstrated that inactive renin concentration did not change significantly 30 and 60 minutes after intravenous furosemide in the normal and hypertensive subjects.…”

Section: Figure 4 Dynamic Responses Of Active Renin Concentration Imentioning

confidence: 95%

Dynamic responses of active and inactive renin in patients with essential and renovascular hypertension.

Aoi¹,

Doi²,

Seto³

et al. 1981

Hypertension

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SUMMARY We studied the dynamic responses of inactive renln and the form of renin released by the kidney in the hypertensive patients. Significant increase of active renin concentration (p < 0.01) and decrease of the percentage of inactive renin concentration (p < 0.01) after sodium depletion was observed in 15 essential hypertensive subjects with normal plasma renin activity. In eight of 15 patients, significant increase of inactive renin concentration [p < 0.01) was observed after sodium depletion. In the remaining seven patients, no significant change of inactive renin concentration was demonstrated. A small increase of active and inactive renin concentration was observed following sodium depletion in six essential hypertensive subjects with low plasma renin activity (PRA). In the unilateral renal hypertension after upright tilting, active renin concentration in the renal vein of the affected kidney was significantly (p < 0.02) higher than that in the renal vein of the nonaffected kidney and the inferior vena cava. Inactive renin concentration in the renal vein of the affected kidney was significantly (p < 0.02) lower than that in the renal vein of the nonaffected kidney and the inferior vena car a. In four of five cases, the inactive renin concentration in the femoral artery was less than that in the inferior vena cava. Therefore, we might conclude that only active renin was released from the affected kidney, and active renin became inactive by unknown mechanisms; the ischeraic kidney might also activate inactive renin.

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Release of active and inactive renin by the porcine kidney.

Cited by 26 publications

References 14 publications

Intrarenal Distribution of Renin in the Developing Rabbit

Intrarenal Distribution of Renin in the Developing Rabbit

Distribution and Disappearance of Exogenous [125I] Big Renin in the Newborn Puppy

Dynamic responses of active and inactive renin in patients with essential and renovascular hypertension.

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