Release of Histamine in Anaphylaxis

Silva, M. Rocha e

doi:10.1007/978-3-662-12016-3_19

Cited by 13 publications

(7 citation statements)

References 218 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The first direct proof of the release of a substance with biological effects similar to those of histamine was supplied by Bartosch, Feldberg & Nagel (1932), who added an antigen to the perfused lung of a sensitized guinea-pig. Their conclusion has been verified by spectrophotometric analysis for histamine contained in blood or perfusate from the lung in anaphylaxis (see references cited by Rocha e Silva, 1966).…”

Section: Introductionmentioning

confidence: 78%

Pharmacological significance of biogenic amines in the lungs: histamine

Aviado

Sadavongvivad

1970

British J Pharmacology

View full text Add to dashboard Cite

Summary . Eight animal species were investigated for the histamine content of the lung and can be divided into two groups: the low‐level group, ranging from 2 to 7 μg/g, consisting of the mouse, rat, guinea‐pig and rabbit; and the high‐level group, ranging from 12 to 35 μg/g, consisting of the cat, dog, goat and human. In two species of the high‐level group (cat and dog) the amount of histamine that elicited an increase in pulmonary resistance was one‐fifth to one‐tenth of the dose that elicited an increase in species of the low‐level group (rat and rabbit). There is an inverse relationship between the content of histamine and the dose of histamine that produces a 25% increase in pulmonary resistance. . Anaphylaxis increases the histamine content of the lung of the rabbit but not of the lung of the guinea‐pig. In both species, anaphylaxis is accompanied by an elevation of the concentration of 5‐hydroxytryptamine in the lung, indicating the trapping of platelets in the lung. . The development of severe parasitaemia in the mouse inoculated with Plasmodium berghei is accompanied by an elevation of the histamine content of the lung. This increase appears to be part of the response of the lung to parasitaemia.

show abstract

Section: Introductionmentioning

confidence: 78%

Pharmacological significance of biogenic amines in the lungs: histamine

Aviado

Sadavongvivad

1970

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…This omission is surprising, since there is consensus that obstruction of the airways underlies lethality of inhaled histamine in this species. 20 Instead, discussion centred around the cardiotoxic potential of propellants and the propensity of racisoprenaline to influence cardiac function. Adverse clinical effects of rac-isoprenaline and, latterly, rac-fenoterol 21,22 SYMPATHOMIMETIC ENANTIOMERS AND ASTHMA continue to be attributed to cardiac effects.…”

Section: Loss Of Efficacymentioning

confidence: 99%

Sympathomimetic enantiomers and asthma

et al. 1998

View full text Add to dashboard Cite

“…Histamine was first demonstrated by Best, Dale, Dudley & Thorpe (1927) to be present in the lung tissue. There is adequate demonstration of the release of histamine from the lung tissue under special conditions (see references cited by Rocha e Silva, 1966). 5-HT is found in relatively high concentrations in many mammalian lungs and is released in pulmonary embolism (Smith & Smith, 1955) and anaphylaxis (Waalkes, Weissbach, Bozicevich & Udenfriend, 1957).…”

Section: Introductionmentioning

confidence: 99%

Pharmacological significance of biogenic amines in the lungs: 5‐hydroxytryptamine

Sadavongvivad

1970

British J Pharmacology

View full text Add to dashboard Cite

Summary . A technique for the spectrofluorometric analysis of 5‐hydroxytryptamine, histamine, noradrenaline and dopamine in a single lung sample has been developed. The method is a combination of the extraction procedure of Shore & Olin (1958), plus the modification introduced by Hogans (1967) for the analysis of three of the four amines. The fourth amine, histamine, was analysed by the method of Shore, Burkhalter & Cohn (1959), which was combined with the analysis of the other three amines. The combined procedure consisted principally of disintegrating the lung tissue in butanol and subsequent separation of amines for measurement of fluorescence, either directly, as for 5‐hydroxytryptamine, or after formation of fluorophores, as for histamine, noradrenaline and dopamine. It has been possible to analyse all four amines from a sample of the lung in which the bronchopulmonary responses have been investigated. . The concentration of 5‐hydroxytryptamine in the lung of seven species ranges from about 0·5 μg/g in the guinea‐pig, dog and man to about 7 μg/g in the rabbit. The pulmonary resistance is increased after an injection of 5‐hydroxytryptamine in the rat and guinea‐pig. . The guinea‐pig is more sensitive to 5‐hydroxytryptamine than the rat. In both animal species, the content of 5‐hydroxytryptamine in the lung is elevated by administration of either 5‐hydroxytryptamine or 5‐hydroxytryptophan. In the rat, the administration of p‐chlorophenylalanine reduces the content of 5‐hydroxytryptamine in the brain but not in the lung. . It is suggested that the 5‐hydroxytryptamine contained in the lung tissue is stored mainly in the platelets and in the mast cells.

show abstract

Release of Histamine in Anaphylaxis

Cited by 13 publications

References 218 publications

Pharmacological significance of biogenic amines in the lungs: histamine

Pharmacological significance of biogenic amines in the lungs: histamine

Sympathomimetic enantiomers and asthma

Pharmacological significance of biogenic amines in the lungs: 5‐hydroxytryptamine

Contact Info

Product

Resources

About