Release of hypothalamic cholecystokinin in cats: effects of nutrient and volume loading

Schick, R.; Yaksh, Tony L.; Roddy, Diane R.; Go, Vay Liang W.

doi:10.1152/ajpregu.1989.256.1.r248

Cited by 20 publications

(20 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…More recent experiments have shown that CCK-LI is released in the lateral hypothalamus during food intake (4,16,17). In the present study, we found that the concentration of CCK-LI in the CSF of male rats decreased in response to 48 h of food deprivation and was restored after 1 h of food intake.…”

Section: Discussionsupporting

confidence: 67%

“…We suggested that peripheral CCK-8 may exert a triggering effect on the central neural pathways which control food intake (2). In fact, CCK may serve as a neurotransmitter in these pathways (2)(3)(4). Thus, sensory information from the gastrointestinal tract is relayed via gastric vagal afferents to the parvocellular division of the nucleus of the holitary tract (5,6) and further to the parabrachial nucleus in the pons (7).…”

mentioning

confidence: 99%

“…Moreover, intracerebroventricular (icv), but not ip, injection of a low dose of proglumide, a CCK antagonist, prevented the effect of ip CCK-8 on food intake (2). Additionally, it has been reported that CCK-like immunoreactivity (CCK-LI) is released from the hypothalamus in response to food intake (4,16,17) and after ip injection of CCK-8 (18). Hypothetically, therefore, central CCK may be involved in the regulation of food intake.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Involvement of Cholecystokinin in Food Intake: I. Concentrations of Cholecystokinin‐Like Immunoreactivity in the Cerebrospinal Fluid of Male Rats

Lindén

Uvnäs‐Moberg

Forsbergt

et al. 1990

J Neuroendocrinology

View full text Add to dashboard Cite

To investigate the role of central neural cholecystokinin in food intake the concentration of cholecystokinin-like immunoreactivity was measured by radioimmunoassay in the cerebrospinal fluid of male rats. Characterization of the molecular forms of cholecystokinin was made by high-performance liquid chromatography before radioimmunoassay. Four molecular forms of cholecystokinin corresponding to standards of the tetra-, penta-and sulphated octapeptide and a late eluting peak probably corresponding to cholecystokinin-58 were found. The concentration of cholecystokinin-like immunoreactivity in the cerebrospinal fluid decreased in response to 48 h of food deprivation and was restored after 1 h of food intake, the main increase occurring within 30 min after the onset of feeding. Cholecystokinin-like immunoreactivity increased in the cerebrospinal fluid 10 min after an intraperitoneal injection of 5 pg cholecystokinin octapeptide, a dose which also suppressed the amount of food consumed during 1 h in rats deprived of food for 48 h. lntraperitoneal injection of the peripheral, cholecystokinin A receptor antagonists lorglumide (450 pg) or L-364. 718 (20 pg) reversed the inhibitory effect of cholecystokinin octapeptide on food intake and prevented the increase of cholecystokininlike immunoreactivity in the cerebrospinal fluid. It is suggested that central neural cholecystokinin is involved in the control of food intake and that this is reflected in the alterations in cholecystokinin-like immunoreactivity in the cerebrospinal fluid which occur in response to food deprivation and food intake. However, a variety of ways of intracerebral administration of cholecystokinin octapeptide failed to affect food intake in food-deprived rats. The possibility is raised that cholecystokinin octapeptide acts in concert with another transmitter in the brain to affect food intake

show abstract

Section: Discussionsupporting

confidence: 67%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Involvement of Cholecystokinin in Food Intake: I. Concentrations of Cholecystokinin‐Like Immunoreactivity in the Cerebrospinal Fluid of Male Rats

Lindén

Uvnäs‐Moberg

Forsbergt

et al. 1990

J Neuroendocrinology

View full text Add to dashboard Cite

show abstract

“…Since these were dose response studies, it obviously cannot be determined whether these regions actually encounter similar concentrations of CCK as the result of changes in appetite or satiety. In cats, 119 CCK can be released from neurons in the lateral hypothalamus in response to gastric infusion of nutrients as well as to volumetric distension by water alone. Peripheral CCK was demonstrated not to be involved using a set of control cats infused IV with exogenous CCK.…”

Section: B Central and Peripheral Regulatory Factorsmentioning

confidence: 99%

The influence of food on food intake: Methodological problems and mechanisms of action

1991

Critical Reviews in Food Science and Nutrition

View full text Add to dashboard Cite

Emphasis has been placed on the understanding of the regulation of food intake in the hope of aiding the battle against obesity and of helping to ameliorate the anorexia of cancer and eating disorders. Available data suggest that the regulatory system is multifaceted and complex. This review focuses on current research on the regulation of appetite and satiety by carbohydrates, fats, and proteins as well as by artificial sweeteners. Some methodological problems and potential mechanisms of action at the biochemical level are discussed. Evidence suggests that organisms are more successful in defending against calorie dilution than in adjusting to increases in calories. The implications of that defense relative to the use of ersatz nutrients are explored.

show abstract

“…The mechanism is believed to include gastric distension and possibly other signals from the upper intestinal tract mediated through the vagus nerve (Lorenz, 1983). Gastric loads of nutrient or nonnutrient solutions stimulate the release of CCK in the lateral hypothalamus of anesthetized adult cats (Schick, Yaksh, Roddy, & Go, 1989). Perhaps central cholecystokinin is part of the gastric distension mechanism, a mechanism suspected to be involved in the control of intake by rats of all ages, regardless of the mode of ingestion (Lorenz, 1992).…”

mentioning

confidence: 99%

Effects of CCK‐8 on ingestive behaviors of suckling and weanling rats

Lorenz

1994

Developmental Psychobiology

View full text Add to dashboard Cite

The present series of experiments was designed to determine the dose-response characteristics of the cholecystokinin suppression effect on rat pups ingesting through suckling and adult modes. Pups at 10-22 days of age were deprived of their dam and food for 6 hr. At test time, the subjects received intraperitoneal injections or intravenous infusions of CCK-8 at 2, 4, 8, or 16 micrograms/kg in saline, or the saline vehicle alone. The pups were permitted to ingest for 30 min immediately after the injection or during the infusion. Ingestion included taking milk from the dam by suckling or feeding from the substrate. Regardless of the route of administration, CCK-8 elicited a low level of suppression across all doses and all ages when pups ingested within the natural suckling situation. In marked contrast, pups ingesting from the substrate in the adult mode suppressed their intake of bovine light cream or chow pellets in a dose-related manner following injections of the peptide. The blockade of the CCK dose-related suppression effect during suckling indicates that a different set of mechanisms governs intake of milk from the mother. The results may be related to the level of arousal required to sustain motivated behaviors while pups engage in the different modes of ingestion.

show abstract

Release of hypothalamic cholecystokinin in cats: effects of nutrient and volume loading

Cited by 20 publications

References 0 publications

Involvement of Cholecystokinin in Food Intake: I. Concentrations of Cholecystokinin‐Like Immunoreactivity in the Cerebrospinal Fluid of Male Rats

Involvement of Cholecystokinin in Food Intake: I. Concentrations of Cholecystokinin‐Like Immunoreactivity in the Cerebrospinal Fluid of Male Rats

The influence of food on food intake: Methodological problems and mechanisms of action

Effects of CCK‐8 on ingestive behaviors of suckling and weanling rats

Contact Info

Product

Resources

About