Release of naltrexone on buccal mucosa: Permeation studies, histological aspects and matrix system design

Construction and in vitro characterization of an optimized porosity-enabled amalgamated matrix for sustained transbuccal drug delivery

“…Subsequently, the trimmed specimens were snap frozen in liquid nitrogen and stored at −70 • C for up to 2 months. Researchers have reported that freezing tissue specimens (either snap freezing with liquid nitrogen or in a standard freezer) does not change their diffusion or permeation behaviour when used for such studies (Van der Bijl et al, 1998; Van Eyk and Thompson, 1998; Van Eyk and Van der Bijl, 2004;Consuelo et al, 2005;Giannola et al, 2007).…”

“…After re-hydration, mucosal disks (diameter = 15 mm and surface area = 2.27 cm 2 ) were cut using surgical scissors from the harvested specimen and mounted in the flow through Franz-type diffusion cell apparatus (Membrane transport systems, V3, Permegear, Amie Systems, USA) connected to a heat-circulating water bath/heating system (CPE 100, Labcon, Maraisburg, Gauteng, South Africa). The receiver compartment contained 10 mL simulated plasma, pH 7.4 (Giannola et al, 2007) while the donor compartment contained a 2 mL solution of the drug-loaded P-EAM formulation in simulated saliva, pH 6.8 (Peh and Wong, 1999). Uniform mixing within the receiver compartment was achieved by magnetic stirring.…”

Development and evaluation of novel trans-buccoadhesive bilayer tablets of Famotidine

“…After 8 h formalin-fixed, paraffin-embedded samples were cut in 4-µm thick sections on a microtome with a disposable blade and conveniently stained with eosin. [18] In vivo drug-release study Six male Newzealand white rabbits (2-2.5 kg) were selected. The dose of Famotidine was adjusted based on the rabbit weight and the best formulations (F5) were placed in the buccal membrane with the adhesive layer.…”

Transbuccal delivery of doxepin: Studies on permeation and histological investigation

“…Continuous research for the improvement of the oral cavity drug delivery has resulted in the development of several dosage forms which can be broadly classified into liquid, semi-solid, solid or spray formulations (Sudhakar et al, 2006). Furthermore, several drugs highly administered by other routes have been assayed through buccal mucosa (Birudaraj et al, 2005;Mashru et al, 2005;Giannola et al, 2007). Within this context, buccal administration could be an alternative, non-invasive delivery route also for doxepin hydrochloride.…”