“…Although bacterial PI-PLCs are not hemolytic toward mammalian erythrocytes, cytotoxic or physiological actions on eucaryotic cells have been expected. Actually, PI-PLCs of B. cereus and B. thuringiensis proved to bring about growth inhibition of cultured eucaryotic cells in vitro and in vivo (Ikezawa et al, 1982(Ikezawa et al, -1983(Ikezawa et al, , 1985(Ikezawa et al, , 1989Itami et al, 1997). For instance, both PI-PLCs significantly inhibited the cell growth of Sarcoma 180 ascites tumor transplanted intraperitoneally into mice peritoneum (Ikezawa et al, 1982(Ikezawa et al, -1983.…”