Release profile of lidocaine HCl from topical liposomal gel formulation

Dodov, Marija Glavaš; Goračinova, Katerina; Mladenovska, Kristina; Fredro-Kumbaradzi, Emilija

doi:10.1016/s0378-5173(02)00221-1

Cited by 101 publications

(59 citation statements)

References 4 publications

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“…The release of gentamicin sulphate from niosomes was determined using the membrane diffusion technique (25)(26)(27)). An accurately measured amount of gentamicin sulphate niosomal formulations, equivalent to 1 mg drug, was suspended in 0.3 ml phosphate buffered saline (pH 7.4) and transferred to a glass cylinder having the length of 10 cm and diameter of 2.5 cm fitted at its lower end with presoaked cellulose membrane (Spectra/Por dialysis membrane 12,000-14,000 Mwt cutoff).…”

Section: In Vitro Release Of Gentamicin Sulphate From Niosomesmentioning

confidence: 99%

Niosome-Encapsulated Gentamicin for Ophthalmic Controlled Delivery

2008

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Abstract. The objective of the present research was to investigate the feasibility of using non-ionic surfactant vesicles (niosomes) as carriers for the ophthalmic controlled delivery of a water soluble local antibiotic; gentamicin sulphate. Niosomal formulations were prepared using various surfactants (Tween 60, Tween 80 or Brij 35), in the presence of cholesterol and a negative charge inducer dicetyl phosphate (DCP) in different molar ratios and by employing a thin film hydration technique. The ability of these vesicles to entrap the studied drug was evaluated by determining the entrapment efficiency %EE after centrifugation and separation of the formed vesicles. Photomicroscopy and transmission electron microscopy as well as particle size analysis were used to study the formation, morphology and size of the drug loaded niosomes. Results showed a substantial change in the release rate and an alteration in the %EE of gentamicin sulphate from niosomal formulations upon varying type of surfactant, cholesterol content and presence or absence of DCP. In-vitro drug release results confirmed that niosomal formulations have exhibited a high retention of gentamicin sulphate inside the vesicles such that their in vitro release was slower compared to the drug solution. A preparation with 1:1:0.1 molar ratio of Tween 60, cholesterol and DCP gave the most advantageous entrapment (92.02%±1.43) and release results (Q 8h =66.29%±1.33) as compared to other compositions. Ocular irritancy test performed on albino rabbits, showed no sign of irritation for all tested niosomal formulations.

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Section: In Vitro Release Of Gentamicin Sulphate From Niosomesmentioning

confidence: 99%

Niosome-Encapsulated Gentamicin for Ophthalmic Controlled Delivery

2008

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“…The release of SS from niosomes was determined using the membrane diffusion technique [17][18]. One ml phosphate buffer (pH 7.4) was used to suspend SS; equivalent to 10 mg.…”

Section: In Vitro Release Of Ss From Niosomesmentioning

confidence: 99%

Nano-Vesicles of Salbutamol Sulphate in Metered Dose Inhalers: Formulation, Characterization and in Vitro Evaluation

Arafa

Ayoub

2017

Int J App Pharm

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Objective: The present work was aimed to prepare niosomes entrapping salbutamol sulphate (SS) using reversed phase evaporation method (REV).Methods: Niosomes were prepared by mixing span 60 and cholesterol in 1:1 molar ratio in chloroform, SS in water was then added to organic phase to form niosomal SS. Formulations after evaporation of chloroform, freeze centrifuged then lyophilized, were evaluated for particles size, polydispersity index (Pdi), zeta-potential, morphology, entrapment efficiency (EE%) and in vitro release. For pulmonary delivery; metered dose inhalers (MDI) were prepared by suspending SS niosomes equivalent to 20 mg SS in hydrofluoroalkane (HFA). The metered valve was investigated for leakage rate, the total number of puffs/canister, weight/puff, dose uniformity and particle size. Results:The results showed spherical niosomes with 400-451 nm particles that entrapped 66.19% of SS. 76.54±0.132% SS release from niosomes that showed a controlled release profile for 8h. The leakage test was not exceeding 4 mg/3 d, the number of puffs were up to 200puffs/canister, the dose delivered/puff was 0.1 mg and 0.64-4.51μm niosomal aerosol. Conclusion:The results indicate an encouraging strategy to formulate a controlled drug delivery by entrapping (SS) in niosomes which could be packaged into (MDI) that met the requirements of (USP) aerosols guidelines which offering a novel approach to respiratory delivery.

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“…From the obtained data, DFS release was retarded by liposomal incubation in the gel form. Lower release rate from liposome gel systems compared to basic liposome dispersion could be a result of the influence of the viscosity of the gel matrix followed by slower drug penetration 17 . Table 3 illustrates the kinetic studies of the release data, the data fitted Higuchi release kinetics, suggesting that, the drug transport occurred mainly by diffusion controlled mechanism.…”

Section: Figure 2: In-vitro Release Of Diclofenac Sodium From Mlvs LImentioning

confidence: 99%

“…From the obtained data, positively charged liposomes showed the highest stability as manifested by the highest drug retention, followed by negatively charged liposomes, then neutral liposomes. Surface charge is one of the important factors that enhance the stability by reducing the aggregation rate and fusion of liposomal system during the storage 17 .…”

Section: Figure 2: In-vitro Release Of Diclofenac Sodium From Mlvs LImentioning

confidence: 99%

Untitled

2013

IJPSR

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The aim of this work is to formulate topically effective controlled release ophthalmic liposomal gel for targeting diclofenac sodium to the eye in an attempt to heal the inflamed tissue of ocular ulcerative area. Large unilamellar vesicles (LUVs) and multilamellar vesicles (MLVs) gel formulations composing of phosphatidylcholine (PC) and cholesterol (CH) in the molar ratios of (7:2; 7:4 and 7:7) with or without stearylamine (SA) or dicetylphosphate (DP) were prepared using reversed-phase evaporation and lipid film hydration methods respectively. The prepared liposomal systems were evaluated for their entrapment efficiency, morphological characters, physical stability, particle size and drug release rate .LUVs entrapped greater amount of drug than MLVs. Drug loading was increased by increasing CH content as well as by inclusion of SA into the lipid bilayer. Drug release rate showed an order of negatively > neutral > positively charged liposomes, which is the reverse of results of drug loading efficiency. Physical stability study indicated that 92. 56%, 84.11%, 76.41% and 91.1%, 82.19% and 75.54% of diclofenac sodium was retained in positive, negative, and neutral MLVs and LUVs respectively after storing for 120 days at refrigeration temperature. The in vivo anti-inflammatory activity was evaluated using a thermal technique , results showed that the percentage of healed ulcers were 12.5%, 35%, 67.5%, 82.5%, 85%, 87.5% and 95% for negative control, positive control, 0.5% carbopol 934 gel, LUVs liposomes suspension, MLVs liposomes suspension, LUVs and MLVs gels, respectively.

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Release profile of lidocaine HCl from topical liposomal gel formulation

Cited by 101 publications

References 4 publications

Niosome-Encapsulated Gentamicin for Ophthalmic Controlled Delivery

Niosome-Encapsulated Gentamicin for Ophthalmic Controlled Delivery

Nano-Vesicles of Salbutamol Sulphate in Metered Dose Inhalers: Formulation, Characterization and in Vitro Evaluation

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