Release property of temperature-sensitive alginate beads containing poly(N-isopropylacrylamide)

Kim, Mi Hee; Kim, Jin‐Chul; Lee, Hyeon Yong; Kim, Jong Dai; Yang, Jihoon

doi:10.1016/j.colsurfb.2005.09.002

Cited by 53 publications

(25 citation statements)

References 16 publications

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“…Indeed, thermosensitive beads or microspheres were obtained by developing interpenetrating polymer networks (IPN) or semi-IPN between poly(N-isopropyl acrylamide) (poly-NIP-AAM) and CaAlg hydrogels. Thermosensitive beads were also obtained by grafting poly-NIPAAM onto alginate chains [20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Novel thermosensitive calcium alginate microspheres: Physico-chemical characterization and delivery properties

et al. 2010

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Section: Introductionmentioning

confidence: 99%

Novel thermosensitive calcium alginate microspheres: Physico-chemical characterization and delivery properties

et al. 2010

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“…Swelling ratio of alginate/PNIPAM copolymer beads 19 According to the result of SEM, the pores of freezedried bead are much larger than those of air-dried ones (Fig. 3).…”

Section: Determination Of Amount Of Nipam Copolymers Leached Out Of Bmentioning

confidence: 97%

“…Once alginate has been crosslinked by multivalent ions, the linkage is stable and robust with respect to pH change. 19 That is why the degree of swelling is almost constant with pH. Whereas, P(NIPAM-co-MAA-co-ODA) within the matrix could form variable size of aggregates depending on pH, leading to pH-dependent release of alginate/P(NIPAM-co-MAA-co-ODA) bead [ Fig.…”

Section: Determination Of Amount Of Nipam Copolymers Leached Out Of Bmentioning

confidence: 99%

“…The releases from the beads were suppressed below the lower critical solution temperature, whereas above that temperature the release became extensive. 19 In this study, poly(N-isopropylacrylamide) (PNIPAM), the copolymer of N-isopropylacrylamide and methacrylic acid (P(NIPAM-co-MAA)), and the copolymer of N-isopropylacrylamide, methacrylic acid, and octadecylacrylate (P(NIPAM-co-MAA-co-ODA)) were prepared by a free radical reaction.…”

Section: Introductionmentioning

confidence: 99%

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Release behavior of freeze‐dried alginate beads containing poly(N‐isopropylacrylamide) copolymers

Choi

Lee

Kim

2008

J of Applied Polymer Sci

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Beads composed of alginate, poly(N-isopropylacrylamide) (PNIPAM), the copolymers of N-isopropylacrylamide and methacrylic acid (P(NIPAM-co-MAA)), and the copolymers of N-isopropylacrylamide, methacrylic acid, and octadecyl acrylate (P(NIPAM-co-MAA-co-ODA)), were prepared by dropping the polymer solutions into CaCl 2 solution. The beads were freeze-dried and the release of blue dextran entrapped in the beads was observed in distilled water with time and pH. The degree of release was in the order of alginate bead < alginate/ PNIPAM bead % alginate/P(NIPAM-co-MAA) bead < alginate/P(NIPAM-co-MAA-co-ODA) bead. On the other hand, swelling ratios reached steady state within 20 min, and the values were 200-800 depending on the bead composition. The degree of swelling showed the same order as that of release. Among the beads, only alginate/P(NIPAMco-MAA-co-ODA) bead exhibited pH-dependent release. At acidic condition, inter-and intraelectrostatic repulsion is weak and P(NIPAM-co-MAA-co-ODA) could readily be assembled into an aggregate due to the prevailing hydrophobic interaction of ODA. Thus, it could block the pore of bead matrix, leading to a suppressed release.

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“…27,28 In the spectra of IPNs, this peak is hidden by a broad amide II band of PNIPAAm at 1653 cm À1 , as noted earlier. The absorbance at 1082 and 1090 cm À1 in the spectra of CA and IPNs, respectively, is a result of CAOAC stretching of the pyranose ring in mannuronate (M) and guluronate (G) residues.…”

mentioning

confidence: 88%

Development and characterization of thermosensitive hydrogels based on poly(N‐isopropylacrylamide) and calcium alginate

Petruš̆̌̌̌ić

Lewandowski

Giraud

et al. 2011

J of Applied Polymer Sci

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This work refers to the synthesis and characterization of thermosensitive hydrogels based on interpenetrating polymer networks (IPNs) of poly(N-isopropylacrylamide) (PNIPAAm) and calcium alginate in the form of films. The influence of the crosslinking degree of PNIPAAm and alginate content on thermal, swelling, mechanical, and morphological properties of hydrogels is investigated in detail. Characterization of pure PNIPAAm hydrogels and IPN hydrogels was performed by FTIR, DSC, DMA, and SEM. In addition, the studies of equilibrium swelling behavior as well as swelling, deswelling, and reswelling kinetics are performed.The results obtained imply the benefits of synthesizing IPNs based on PNIPAAm and calcium alginate over pure PNIPAAm hydrogels. The presence of calcium alginate contributes to the improvement of mechanical properties, the deswelling rate of hydrogels, and the network porosity, without altering the thermosensitivity of PNIPAAm significantly.

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Release property of temperature-sensitive alginate beads containing poly(N-isopropylacrylamide)

Cited by 53 publications

References 16 publications

Novel thermosensitive calcium alginate microspheres: Physico-chemical characterization and delivery properties

Novel thermosensitive calcium alginate microspheres: Physico-chemical characterization and delivery properties

Release behavior of freeze‐dried alginate beads containing poly(N‐isopropylacrylamide) copolymers

Development and characterization of thermosensitive hydrogels based on poly(N‐isopropylacrylamide) and calcium alginate

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