Relevance of CT and MRI in retinoblastoma for the diagnosis of postlaminar invasion with normal-size optic nerve: a retrospective study of 150 patients with histological comparison

Brisse, H.; Guesmi, M.; Aerts, Isabelle; Sastre-Garau, Xavier; Savignoni, Alexia; Rouic, Livia Lumbroso‐Le; Desjardins, Laurence; Doz, François; Asselain, Bernard; Bours, Danièle; Neuenschwander, S.

doi:10.1007/s00247-007-0491-4

Cited by 92 publications

(83 citation statements)

References 24 publications

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“…Non-EP DWI was performed by using a HASTE sequence with b-values of 0 and 1000 s/mm 2 . ADC values were measured for enhancing and nonenhancing tumor tissue.…”

Section: Methodsmentioning

confidence: 99%

Single-Shot Turbo Spin-Echo Diffusion-Weighted Imaging for Retinoblastoma: Initial Experience

Graaf¹,

Pouwels²,

Rodjan

et al. 2011

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Retinoblastoma may exhibit variable hyperintensities on DWI, resulting in different values in the ADC maps, depending on their histology and cellularity. However, EP-based DWI has susceptibility artifacts and image distortions, which make DWI of the orbit a challenging technique. The aim of this study was to investigate the feasibility of single-shot turbo spin-echo (HASTE) DWI in the evaluation of children with retinoblastoma and to assess the value of ADC maps in differentiating viable and necrotic tumor tissue.

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“…Non-EP DWI was performed by using a HASTE sequence with b-values of 0 and 1000 s/mm 2 . ADC values were measured for enhancing and nonenhancing tumor tissue.…”

Section: Methodsmentioning

confidence: 99%

Single-Shot Turbo Spin-Echo Diffusion-Weighted Imaging for Retinoblastoma: Initial Experience

Graaf¹,

Pouwels²,

Rodjan

et al. 2011

AJNR Am J Neuroradiol

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“…Galluzzi et al 18 published a series of 16 eyes and found a correlation between histopathologic optic nerve and/or choroid invasion and AES enhancement on MR imaging; however, no correlation between clinical or histopathologic presence of IA and AES enhancement could be detected. On the other hand, Brisse et al 8 could not confirm this correlation between AES enhancement and optic nerve invasion in 10 eyes. To our knowledge, the present investigation is the most comprehensive study so far in the search for an explanation for variable AES enhancement in retinoblastoma, which confirmed the role of IA in vivo.…”

Section: Discussionmentioning

confidence: 86%

“…6,8,18 Authors of these studies correlated AES enhancement with clinical and histopathologic findings. De Graaf et al 6 reported the clinical presence of IA, hyperemia, or inflammation as possible explanations for AES enhancement.…”

Section: Discussionmentioning

confidence: 99%

“…6,8,18 Surprisingly, this phenomenon is barely reported in the literature, and underlying pathophysiology and its histopathologic correlates are still unclarified. We postulated that AES enhancement may reflect the status of retinoblastoma-induced IA in vivo.…”

mentioning

confidence: 99%

“…[2][3][4] MR imaging provides the opportunity for a noninvasive evaluation of these risk factors with reasonable diagnostic accuracy. [5][6][7][8] Tumor angiogenesis is also a histopathologic risk factor for local tumor invasion and systemic dissemination in retinoblastoma 9,10 ; initial reports on vascular targeting therapy in mouse models of retinoblastoma show promising results. 11 However, evaluation of angiogenic activity has been performed only in vitro on the histopathology of enucleated eyes.…”

mentioning

confidence: 99%

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Contrast-Enhancement of the Anterior Eye Segment in Patients with Retinoblastoma: Correlation between Clinical, MR Imaging, and Histopathologic Findings

Graaf¹,

Valk²,

Moll³

et al. 2009

AJNR Am J Neuroradiol

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Comparison of Staging Systems for Extraocular Retinoblastoma

et al. 2013

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IMPORTANCE Different staging systems for extraocular retinoblastoma have been published, but to date they have not been validated in large cohorts.OBJECTIVE To review 533 patients (and pathology slides) with retinoblastoma included in 4 protocols (January 1, 1988, to December 31, 2009 who received uniform treatment.DESIGN AND SETTING Retrospective review in a hospital setting. A critical analysis for detecting inconsistencies and omissions was performed.PARTICIPANTS Patients were reclassified according to the modified St Jude Children's Research Hospital staging system, Grabowski-Abramson staging system, International Retinoblastoma Staging System (IRSS), and American Joint Committee on Cancer TNM staging system. MAIN OUTCOME AND MEASUREThe main outcome measure was disease-free survival (DFS), considering only extraocular relapse as an event. RESULTSIn the IRSS and the St Jude system, higher stages correlated with poorer DFS. For intraocular disease, only the TNM system and the IRSS included pathological definitions, and all systems except for the IRSS included substages without differences in DFS. Omissions of factors significantly associated with lower DFS included scleral invasion by the TNM system and massive choroidal invasion by the Grabowski-Abramson system. The St Jude system omits postlaminar optic nerve involvement, but this omission did not correlate significantly with lower DFS because these patients received intensive therapy. No differences in DFS were observed among substages for metastatic disease except for the presence of central nervous system involvement. All staging systems had inconsistencies in definitions of extent of disease. No system provides guidelines for imaging. CONCLUSIONS AND RELEVANCEOnly the IRSS and the St Jude system allowed for grouping of patients with increasing risk of extraocular relapse. For lower stages, only the IRSS considers all unequivocal pathological prognostic factors. For higher stages, all systems had redundant information, resulting in an excess of substages.

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Relevance of CT and MRI in retinoblastoma for the diagnosis of postlaminar invasion with normal-size optic nerve: a retrospective study of 150 patients with histological comparison

Abstract: Our results suggest that MRI is more relevant than CT for preoperative detection of optic nerve invasion in patients with retinoblastoma. Tumour diameter is the only indirect sign significantly associated with postlaminar invasion.

Cited by 92 publications

References 24 publications

Single-Shot Turbo Spin-Echo Diffusion-Weighted Imaging for Retinoblastoma: Initial Experience

Single-Shot Turbo Spin-Echo Diffusion-Weighted Imaging for Retinoblastoma: Initial Experience

Contrast-Enhancement of the Anterior Eye Segment in Patients with Retinoblastoma: Correlation between Clinical, MR Imaging, and Histopathologic Findings

Comparison of Staging Systems for Extraocular Retinoblastoma

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