Relevance of erythrocyte deformability to the concentration of soluble cell adhesion molecules and glomerular filtration rate in patients with untreated essential hypertension

The Role of Red Blood Cell Deformability and Na,K-ATPase Function in Selected Risk Factors of Cardiovascular Diseases in Humans: Focus on Hypertension, Diabetes Mellitus and Hypercholesterolemia

“…The importance of RBC deformability determination in patients suffering from essential hypertension was documented by correlation between this parameter and the levels of soluble vascular adhesion molecules-1 as well as soluble intracellular adhesion molecules-1 in circulation. Therefore, deformability of RBC may serve as a marker of endothelial dysfunction at least in hypertensives (Fornal et al 2011).…”

Physiological and pathophysiological significance of erythrocyte senescence, density and deformability: Important but unnoticed trinity

“…These rheologic impacts increase the flow resistance in microcirculation and impose the mechanical shear stress on erythrocytes. The impaired erythrocyte deformability is confirmed in hypertensive patients by several rheological methods [64][65][66]. However, these studies reported no differences of MCHC and MCV in hypertensives from those in controls, implying that reduced deformability in erythrocytes of hypertensives are not due to the increased cellular size or density but likely caused by the rise in [Ca 2+ ] i and membrane properties altered by mechanical and oxidative stress under the reduced NO availability [65,66].…”

Correlações entre a estabilidade osmótica da membrana de eritrócitos e índices hematológicos e bioquímicos durante tratamento com estatina

“…Essa conclusão é fortalecida pelo fato das análises de correlação canônica terem mostrado que LDL-C e t-C, nessa ordem, terem sido as variáveis que tiveram as melhores correlações com as variáveis de estabilidade. Níveis mais altos de LDL-C aumentam o teor de colesterol da membrana e uma membrana de eritrócitos com maior teor de colesterol é mais rígida (Menchaca, Michalek et al, 1998;Vaya, Camara et al, 2010;Fornal, Korbut et al, 2011) e osmoticamente mais estável, embora uma elevação excessiva no teor de colesterol de membrana venha a favorecer mesmo a lise hipotônica de eritrócitos (Fig. 2).…”