Relevance of fructose intake in adolescence for fatty liver indices in young adulthood

Perrar, Ines; Buyken, Anette E.; Penczynski, Katharina J.; Kuhnle, Gunter Georg; Herder, Christian; Roden, Michael; Corte, Karen Della; Nöthlings, Ute; Alexy, Ute

doi:10.1007/s00394-020-02463-2

Cited by 10 publications

(9 citation statements)

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“…Previous results of the DONALD study indicated that the intake of flavonoids from fruits and vegetables was inversely associated with fatty liver indices (59) and that large amounts of high glycaemic carbohydrates in the evening might increase fatty liver values (60) . Furthermore, no association was found between fructose intake and fatty liver indices in adulthood (61) . The age of the considered study populations at fatty liver indices measurement during adulthood was very young (around 21 years) indicating that lifestyle in young age can have an influence on early development of liver steatosis.…”

Section: Discussionmentioning

confidence: 84%

A healthy lifestyle during adolescence was inversely associated with fatty liver indices in early adulthood: findings from the DONALD cohort study

et al. 2022

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A healthy lifestyle during adolescence might be associated with insulin sensitivity or liver enzyme levels and thus contribute to the prevention of non-alcoholic fatty liver disease (NAFLD) later in life. Therefore, we examined the association between adherence to a hypothesis-based lifestyle score including dietary intake, physical activity, sedentary behaviour, sleep duration and body mass index in adolescence and fatty liver indices in early adulthood. Overall, 240 participants of the DONALD study completed repeated measurements of the lifestyle score factors during adolescence (females: 8.5-15.5 years, males: 9.5-16.5 years). Multivariable linear regression models were used to investigate the prospective association between adolescent lifestyle scores and NAFLD risk (hepatic steatosis index (HSI) and the fatty liver index (FLI)) in early adulthood (18-30 years). Participants visited the study centre 4.9 times during adolescence and achieved 2.8 (0.6-5) out of 5 lifestyle score points on average. Inverse associations were observed between the lifestyle score during adolescence and fatty liver indices in young adulthood (HSI: -5.8% [-8.3 to -3.1%], p<0.0001, FLI: -32.4% [-42.9 to -20.0%], p<0.0001) in the overall study population. Sex-stratified analysis confirmed these results in men, while inverse but non-significant associations were observed in women (p>0.05). A higher lifestyle score during adolescence was associated with lower HSI and FLI values, suggesting that a healthy lifestyle during adolescence might contribute to NAFLD prevention, predominantly in men. Our findings on repeatedly measured lifestyle scores in adolescents and their association with fatty liver indices in early adulthood warrant confirmation in larger study populations.

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Section: Discussionmentioning

confidence: 84%

A healthy lifestyle during adolescence was inversely associated with fatty liver indices in early adulthood: findings from the DONALD cohort study

et al. 2022

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“…In addition, Lambert et al [ 29 ] have shown that, compared to the control subjects, de novo lipogenesis is 3% higher in the NAFLD subjects. Although contradictory findings exist, most of the epidemiological and clinical studies have shown the association between high fructose consumption (majorly in the form of HFCS) and the risk of NAFLD causation and other metabolic complications, including obesity, insulin resistance, and metabolic syndrome[ 30 - 34 ].…”

Section: Dietary Changes and Nafldmentioning

confidence: 99%

Stearoyl-CoA desaturase 1: A potential target for non-alcoholic fatty liver disease?-perspective on emerging experimental evidence

Jeyakumar¹,

Vajreswari²

2022

WJH

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Non-alcoholic fatty liver disease (NAFLD) is a progressive disease and one of the leading causes of death. An unnamed disease has become a global epidemic disease of public health concern. This spectrum of diseases manifests itself with initial accumulation of excessive triglycerides (due to de novo lipogenesis) in the hepatocytes, leading to simple steatosis. Although its aetiology is multi-factorial, lifestyle changes (diet and physical activity) are considered to be the key thriving factors. In this context, high fructose consumption is associated with an increased risk for developing NAFLD in humans, while high-fructose feeding to experimental animals results in hepatic steatosis and non-alcoholic steatohepatitis, by increasing hepatic lipogenesis. Among several lipogenic genes, the endoplasmic reticulum-bound stearoyl-CoA desaturase 1 (SCD1) is the key determinant of triglycerides biosynthesis pathway, by providing monounsaturated fatty acids, through the incorporation of a double bond at the delta-9 position of saturated fatty acids, specifically, palmitic (C16:0) and stearic (C18:0) acids, yielding palmitoleic (C16:1) and oleic (C18:1) acids, respectively. Various experimental studies involving SCD1 gene knockout and diet-induced rodent models have demonstrated that SCD1 plays a key role in the development of NAFLD, by modulating hepatic lipogenesis and thus triglyceride accumulation in the liver. Several pharmacological and dietary intervention studies have shown the benefits of inhibiting hepatic SCD1 in the pathogenesis of NAFLD. In this review, we give an overview of SCD1 in NAFLD, based on the current experimental evidence and the translational applicability of SCD1 inhibition in human NAFLD conditions, besides discussing the limitations and way-forward.

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“…HFCS (ГФУ) содержит фруктозу и глюкозу в разных пропорциях в зависимости от целевого пищевого продукта: концентрация фруктозы может достигать 90%, но доминируют 42 или 55%. В некоторых странах (США и Япония) HFCS (ГФУ) -важный ее источник [4,13,23]. Фруктоза как компонент сахарозы и HFCS (ГФУ) в качестве подсластителя играет важную роль в индустрии пищевых продуктов.…”

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“…Роль фруктозы в развитии НАЖБП в отдельных популяционных группах. Хотя НАЖБП чаще отмечается у лиц старшего возраста, с развитием эпидемии ожирения отмечается быстрый рост НАЖБП в юной популяции [7,23,32]. Эксперты свидетельствуют, что НАЖБП -наиболее частая причина болезней печени у детей и подростков в США и, возможно, в остальных индустриальных странах [32].…”

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“…При изокалорийном питании не продемонстрировано никакого влияния фруктозы на жир в печени. Поэтому исследователи считают, что потребление сахара следует снизить, особенно в высококалорийных рационах, но в изокалорийных или гипокалорийных рациенах пагубное воздействие углеводов остается спорным [6,7,16,23]. Кроме того, не ясно, существует ли порог безопасности для потребления сладких продуктов питания в профилактике НАЖБП.…”

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Non-Alcoholic Fatty Liver Disease: With a Focus on Fructose

Silivontchik¹,

Штонда²

2021

Hepatol and Gastroenterol

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Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive accumulation of fat in the liver in the absence of secondary causes. The review presents data on the role of fructose in the accumulation of fat in the liver and the mechanisms of NAFLD development. A number of data have been obtained on the effects of fructose, in the form of sugar-containing and fructose-containing drinks, related to NAFLD development.

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Relevance of fructose intake in adolescence for fatty liver indices in young adulthood

Cited by 10 publications

References 65 publications

A healthy lifestyle during adolescence was inversely associated with fatty liver indices in early adulthood: findings from the DONALD cohort study

A healthy lifestyle during adolescence was inversely associated with fatty liver indices in early adulthood: findings from the DONALD cohort study

Stearoyl-CoA desaturase 1: A potential target for non-alcoholic fatty liver disease?-perspective on emerging experimental evidence

Non-Alcoholic Fatty Liver Disease: With a Focus on Fructose

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